Carcinoid of the Stomach-a Case Report and Analysis of 100 Cases Reported in Japan-

Mizuma, Koichi; Kubo, T.; Ishida, K; Shimogawara, Izuru; Kaku, Toshihiro; Uno, Masaru; Fukui, Shiro; Totsuka, Morio; Hayasaka, Hiroshi; Minase, Takashi; Muroya, K

doi:10.3919/ringe1963.43.241

Cited by 6 publications

(9 citation statements)

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“…In these cases, we found a metastasizing rate of 39% (table 5) [3,5,7,20,[56][57][58][59][60][61][62][63][64][65][66][67], Here, however, for the rea sons given above, it is uncertain whether these cases were true sporadic carcinoid tumours. Among the 32 con firmed cases of sporadic carcinoid tumour reported by Rindi et al [5], the metastasizing rate was 65.4%.…”

Section: Discussionmentioning

confidence: 93%

Prognosis of Gastric Carcinoid Tumours

Rappel¹,

Altendorf-Hofmann

Stolte³

1995

Digestion

124

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With the aim of evaluating the prognosis of carcinoid tumours of the stomach, the tumours were classified into subtypes on the basis of the type of gastritis, and a comparison made of the type of treatment, metastasizing rate, and the survival rates of the various groups of patients involved. Of the patients with atrophic autoimmune gastritis (type A gastritis) (n = 88) who had multiple carcinoid tumours in the corpus or fundus, usually not more than 1 cm in diameter, 98% were followed up clinically or by endoscopy and biopsy. In these patients, the metastasizing rate was 0%, and the age-corrected Kaplan-Meier survival rate revealed normal life expectancy. 25% of the patients with sporadic carcinoid tumours (n = 12) – most of whom had a Helicobacter pylori-related gastritis and usually solitary tumours located within the corpus or fundus, 25% of which exceeding 1 cm in diameter – underwent surgical treatment. In these patients the metastasizing rate was 16.7% and the age-corrected survival rate 79%. On the basis of our results, we conclude that, depending upon the subtype involved, the prognosis of gastric carcinoid tumours varies, such that regular endoscopy/biopsy follow-up suffices for patients with type A gastritis, while for patients with sporadic carcinoid tumours, surgical treatment is indicated.

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Section: Discussionmentioning

confidence: 93%

Prognosis of Gastric Carcinoid Tumours

Rappel¹,

Altendorf-Hofmann

Stolte³

1995

Digestion

124

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“…However, with the widespread use of endoscopy and improvements in immunohistological techniques, recent studies have demonstrated that carcinoid tumors may account for large a proportion as 27.3%-41% of all gastrointestinal endocrine tumors [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Minute gastric carcinoid tumor with regional lymph node metastasis

et al. 2003

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gastroscopy and improvements in immunohistological techniques.Rindi et al. [3][4][5] have characterized three clinicopathologic subtypes of gastric carcinoid tumors. Further, the behavior of any gastric carcinoid tumor depends on its size and depth [6,7].So far, a minute gastric carcinoid tumor has been regarded as a benign tumor, for which endoscopic excision is recommended. In this report, we describe a case of minute sporadic gastric carcinoid tumor associated with regional lymph node metastasis. We also present a review of the literature. Case reportA 50-year-old asymptomatic man was referred to our hospital for further evaluation of an elevated lesion on the anterior wall of the gastric body, detected by a series of upper gastrointestinal examinations. Routine hematologic study revealed no abnormality, and liver and kidney functions were normal. Levels of tumor markers, serum gastrin, and urinary 5-hydroxyindole acetic acid (5-HIAA) were all within normal ranges. Careful gastrointestinal examinations disclosed two lesions, a small elevated lesion with a central depression on the anterior wall of the gastric body, and a superficial depressed lesion in the greater curvature, near the elevated lesion (Fig. 1A,B). Computed tomography (CT) and ultrasonography (US) scans of the upper abdomen showed no metastasis. Biopsy specimens revealed that the depressed lesion was consistent with a poorly differentiated adenocarcinoma and the elevated lesion was a typical carcinoid tumor.Because of the low probability of lymph node metastasis, and to preserve the stomach function, segmental gastrectomy, together with perigastric lymph node dissection, was performed (The resected stomach is shown in Fig. 2A). Histologically, the depressed lesion However, the case we present suggests that attention should be paid to the possibility of metastasis at the time of treatment for a minute sporadic gastric carcinoid tumor. We therefore discuss the malignant potential of these tumors, mainly from the viewpoint of histopathological classification, to gain understanding so that the patients can be treated adequately.

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“…These data reflect the incidence picture of gastric neuroendocrine tumors in surgical series. In endoscopic series, however, higher incidences ranging from 11 to 41% of all gastrointestinal endocrine tumors were assessed (Mizuma et al, 1983;Rindi et al, 1993;Sjoblom et al, 1988;Solcia et al, 1991b). Overall, such evidence indicates that the occurrence of gastric carcinoids is not such a rare event in the clinical practice and may reflect both the wide- spread diffusion of endoscopy and the increased awareness of such lesions.…”

Section: Tumorsmentioning

confidence: 99%