Carcinoid tumors of the lung: Immuno- and ligandohistochemistry, analysis of integrated optical density, syntactic structure analysis, clinical data, and prognosis of patients treated surgically

Kayser, Klaus; Kayser, Corinna; Rahn, W; Bovin, Nicolai V.; Gabius, Hans‐Joachim

doi:10.1002/(sici)1096-9098(199610)63:2<99::aid-jso6>3.0.co;2-j

Cited by 44 publications

(24 citation statements)

References 30 publications

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“…The motif for hyaluronan binding is composed of a BX,B repeat (B = Arg, Lys) without participation of any acidic amino acids (Yang et al, 1994). Members of these groups are not only intimately involved in, for example, developmental and tissue repair processes, but also appear to play a role in malignancy, which may be expedient for evaluation of prognosis in certain types of tumor (Guenthert, 1993;Kayser et al, 1996b). Presence of a hyaluronic acid-specific receptor has also been described in human plasma.…”

Section: Miscellaneouscontrasting

confidence: 75%

Animal Lectins

Gabius

1997

European Journal of Biochemistry

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435

342

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Protein and lipid glycosylation is no longer considered as a topic whose appeal is restricted to a limited number of analytical experts perseveringly pursuing the comprehensive cataloguing of structural variants. It is in fact arousing curiosity in various areas of basic and applied bioscience. Well founded by the conspicuous coding potential of the sugar part of cellular glycoconjugates which surpasses the storage capacity of oligonucleotide-or oligopeptide-based code systems, recognition of distinct oligosaccharide ligands by endogenous receptors, i.e. lectins and sugar-binding enzymes or antibodies, is increasingly being discovered to play salient roles in animal physiology. Having inevitably started with a descriptive stage, research on animal lectins has now undubitably reached maturity. Besides listing the current categories for lectin classification and providing presentations of the individual families and their presently delineated physiological significance, this review places special emphasis on tracing common structural and functional themes which appear to reverberate in nominally separated lectin and animal categories as well as lines of research which may come to fruition for medical sciences.Keywords: lectin ; glycoprotein; glycolipid; cell adhesion ; molecular recognition ; inflammation; infection ; fertilization ; signal transduction ; tumor biology.The putative multiplicity of functional implications for protein and lipid glycosylation has fueled vigorous and prolific research activities in the last decade. Although glycobiologists continue to be afflicted with the problem of precisely defining the physiological significance of the puzzling variability and complex pattern of carrier-attached saccharide chains, the notion of inherent ligand properties for recognitive protein-carbohydrate interactions is already well established

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Section: Miscellaneouscontrasting

confidence: 75%

Animal Lectins

Gabius

1997

European Journal of Biochemistry

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435

342

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“…Glycohistochemistry with neoglycoconjugates is, for example, helpful in muscle fiber typing in fixed sections and tumor diagnosis in different classes such as brain, breast, colon, lung or prostate malignancies [326,616,617,[623][624][625][626][627][628][629][630][631]. In addition to diagnostic questions, the binding of distinct sugar epitopes such as A-and H-histoblood group determinants, as shown in figure 29 for the H-epitope, is of predictive importance for prognostic evaluations in lung cancer [632,633]. The pursuit of this analysis can also contribute to clarifying the riddle of the relevance of blood group presence in tumor pathology [634][635][636][637].…”

Section: Glycan Recognitionmentioning

confidence: 99%

Eukaryotic glycosylation: whim of nature or multipurpose tool?

Reuter¹,

Gabius²

1999

Cellular and Molecular Life Sciences (CMLS)

214

141

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Protein and lipid glycosylation is a ubiquitous phenomenon. The task of cataloguing the great structural variety of the glycan part has demanded considerable efforts over decades. This patient endeavor was imperative to discern the inherent rules of glycosylation which cannot affirm assumptions on a purely coincidental nature of this type of protein and lipid modification. These results together with theoretical considerations uncover a salient property of oligosaccharides. In comparison with amino acids and nucleotides, monosaccharides excel in their potential to serve as units of hardware for storing biological information. Thus, the view that glycan chains exclusively affect physiochemical properties of the conjugates is indubitably flawed. This original concept has been decisively jolted by the discovery of endogenous receptors (lectins) for distinct glycan epitopes which are as characteristic as a fingerprint or a signature for a certain protein (class) or cell type. Recent evidence documents that these binding proteins are even endowed with the capacity to select distinct low-energy conformers of the often rather flexible oligosaccharides, granting entry to a new level of regulation of ligand affinity by shifting conformer equilibria. The assessment of the details of this recognition by X-ray crystallography, nuclear magnetic resonance spectroscopy, microcalorimetry and custom-made derivatives is supposed to justify a guarded optimism in satisfying the need for innovative drug design in antiadhesion therapy, for example against viral or bacterial infections and unwanted inflammation. This review presents a survey of the structural aspects of glycosylation and of evidence to poignantly endorse the notion that carrier-attached glycan chains can partake in biological information transfer at the level of cell compartments, cells and organs.

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“…The Feulgen-stained specimen was used to determine the structural entropy and its current [13,11]. These parameters have recently been recognized as a reliable prognostic feature in resected common bronchial carcinomas and carcinoids of adults [11,12,15]. The evaluation of positivity for the proliferation marker Ki-67 (MIB-1) yielded insight into the proliferative status, and the profiling of the vascular system, including the average diffusion distance into the tumor vascularization.…”

Section: Introductionmentioning

confidence: 99%

Endobronchial juvenile hemangioma - a case report of a neonate including immunohistochemical monitoring and nuclear, cellular, and vascular morphometry

Kayser

Zink

Link³

et al. 2001

Virchows Archiv

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A 3-month-old female child suffered from tachypnea and dyspnea with abnormal blood gas values. Chest X-rays revealed an increased transparency of the left lung and a mediastinal shift to the right side. High resolution computed tomography (CT) documented a narrowing of the left upper stem bronchus. Ensuing endoscopy detected an occlusive endobronchial tumor mass that did not infiltrate the bronchial cartilage as confirmed with endobronchial ultrasonic monitoring. Based on gross histological examination of the surgical specimen obtained using sleeve resection, the highly vascularized tumor exhibited an adenomatoid growth pattern with a rather homogeneous population of nuclei. The light microscopical presentation was consistent with a juvenile (infantile) hemangioma, which was confirmed using immunohistochemical examinations despite the display of neuroendocrine features. Although endobronchial juvenile hemangiomas are an extremely rare event in early childhood, this case underscores the necessity to not neglect its occurrence in differential diagnosis.

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Carcinoid tumors of the lung: Immuno- and ligandohistochemistry, analysis of integrated optical density, syntactic structure analysis, clinical data, and prognosis of patients treated surgically

Cited by 44 publications

References 30 publications

Animal Lectins

Animal Lectins

Eukaryotic glycosylation: whim of nature or multipurpose tool?

Endobronchial juvenile hemangioma - a case report of a neonate including immunohistochemical monitoring and nuclear, cellular, and vascular morphometry

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