Carcinoid tumors of the rectum

Orloff, Marshall J.

doi:10.1002/1097-0142(197107)28:1<175::aid-cncr2820280135>3.0.co;2-1

Cited by 133 publications

(42 citation statements)

References 16 publications

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“…The size of the tumour and histological evidence of invasion of the muscularis propria layer of the bowel are correlated with the malignant potential. 5,6 Muscularis propria invasion by carcinoid tumours, which indicates a high risk of metastasis, represents a clinical dilemma, especially when the tumours are ≥ 2 cm in diameter. 5,6 Naunheim et al 6 reported that only 3% (13 of 388) of rectal carcinoid tumours ≤ 1 cm in diameter were metastasized at the time of operation.…”

Section: Discussionmentioning

confidence: 99%

“…1 The overall 5-year survival rate for patients with rectal carcinoid tumours is about 80%, 1,5 and small tumours show better survival rates. 5 Primary tumours in the appendix or rectum have less metastatic potential than those with other sites of origin. The size of the tumour and histological evidence of invasion of the muscularis propria layer of the bowel are correlated with the malignant potential.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 Muscularis propria invasion by carcinoid tumours, which indicates a high risk of metastasis, represents a clinical dilemma, especially when the tumours are ≥ 2 cm in diameter. 5,6 Naunheim et al 6 reported that only 3% (13 of 388) of rectal carcinoid tumours ≤ 1 cm in diameter were metastasized at the time of operation. Although the chance of metastases was 5% for a tumour < 2 cm, 74% (61 of 82) of the rectal carcinoid tumours ≥ 2 cm in diameter demonstrated metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…7 In patients who underwent abdominoperineal resection, the 5-year survival rates were 100% among patients with a tumour < 2 cm in diameter, and 57% among patients with a tumour ≥ 2 cm in diameter. 5 Local resection, therefore, seems to be sufficient for small tumours, unless the tumours invade the muscle layer. Recent developments in endoscopy have produced the possibility of endoscopic resection of small intestinal tumours.…”

Section: Endoscopic Resection Of Carcinoid Tumoursmentioning

confidence: 99%

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Endoscopic Resection of Small Rectal Carcinoid Tumours Using an Aspiration Method with a Transparent Overcap

et al. 2000

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Rectal carcinoid tumours are often small and rarely metastatic. Endoscopic resection may, therefore, be the best treatment for small tumours. We diagnosed rectal carcinoid tumours in four women and three men (mean age 53 years; range, 43 -63) between 1994 and 1999. Tumour depth was evaluated using a high-frequency ultrasonographic probe in five of the seven patients. All tumours were resected by endoscopic mucosal resection using an aspiration method with a transparent overcap. Histologically, all tumours were located within the submucosal layer. Tumour cells were found at the resected margin of the lateral side in one patient, and at the bottom of the margin in another. Both patients were followed up with frequent endoscopy, and no local recurrences have been detected at 1-year or 4-year follow-ups. Ultrasonographic examination before resection is useful to estimate tumour depth. Endoscopic resection by an aspiration method with a transparent overcap is safe and effective for the treatment of small rectal carcinoid tumours.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Endoscopic Resection Of Carcinoid Tumoursmentioning

confidence: 99%

See 2 more Smart Citations

Endoscopic Resection of Small Rectal Carcinoid Tumours Using an Aspiration Method with a Transparent Overcap

et al. 2000

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“…Carcinoids of the rectum less than two cm in diameter and without evidence of invasion of the muscularis upon biopsy can be adequately treated by local excision only, as advo cated by Orloff. 22 Patients with larger le sions or evidence of muscular invasion should undergo standard abdominoperi neal resection.…”

Section: Treatmentmentioning

confidence: 99%