Carcinoid Tumors of the Urinary Tract and Prostate

Murali, Rajmohan; Kneale, Kenneth; Lalak, Nestor J.; Delprado, Warick

doi:10.5858/2006-130-1693-ctotut

Cited by 80 publications

(23 citation statements)

References 87 publications

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“…Primary renal NENs represent a poorly characterized subset of neuroendocrine neoplasms. The current medical knowledge of this disease is limited to case reports, small series, and pooled studies of reports and series (3,4). In 2016, the 4 th edition of the World Health Organization (WHO) Classification of Tumors of the Urinary System and Male Genital Organs reorganized NENs into well-differentiated neuroendocrine tumors (NET), large cell neuroendocrine carcinoma (LC-NEC), small cell neuroendocrine carcinoma (SC-NEC), and pheochromocytoma (5).…”

Section: Introductionmentioning

confidence: 99%

Natural History of Renal Neuroendocrine Neoplasms: A NET by Any Other Name?

et al. 2021

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Renal neuroendocrine neoplasms are rare, with descriptions of cases limited to individual reports and small series. The natural history of this group of neuroendocrine neoplasms is poorly understood. In this study, we queried the Surveillance, Epidemiology and End Results (SEER) database over a four-decade period where we identified 166 cases of primary renal neuroendocrine neoplasms. We observed a 5-year overall survival of 50%. On multivariate analysis, survival was influenced by stage, histology, and if surgery was performed. We observed that patients managed by operative management had a greater frequency of localized or regional stage disease as well as a greater frequency of neuroendocrine tumor, grade 1 histology; whereas those managed non-operatively tended to have distant disease and histologies of neuroendocrine carcinoma, NOS and small cell neuroendocrine carcinoma. This is the largest description of patients with renal neuroendocrine neoplasms. Increased survival was observed in patients with earlier stage and favorable histologies.

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Section: Introductionmentioning

confidence: 99%

Natural History of Renal Neuroendocrine Neoplasms: A NET by Any Other Name?

et al. 2021

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“…Die meisten Patienten mit Karzinoiden der Nieren haben Schmerzen im Bauch oder der Flanke. Häufig finden sich auch eine Hämaturie und Fieber [12,13]. Das typische Karzinoidsyndrom mit serotoninassoziiertem Flash, generalisierten Ödemen und Durchfällen wurde nur sehr selten beschrieben [6,21].…”

Section: Klinikunclassified

“…Die Zellen sind rund, kubisch, zylindrisch oder polygonal mit eosinophilem Zytoplasma und ovalen Kernen. Selten finden sich kleine Herde mit Nekrosen, zytologischen Atypien (Pleomorphie und Hyperchromasie) sowie Hämorrhagien oder Verkalkungen [12]. Das Vorliegen von Nekrosen und Hämorrhagien kann als Zeichen eines gesteigerten Malignitätspotenzials gewertet werden, während Kalzifizierungen Hinweise für eine lange Dauer oder eine teratomatöse Komponente gewertet werden kann [25].…”

Section: Makroskopie Und Histologieunclassified

“…Verkalkungen werden in bis zu 30 % der Patienten beschrieben. Murali et al [12] Durch ihr langsames und symptomloses Wachstum werden Nierenkarzinoide erst entdeckt, wenn sie relativ groß sind. Die meisten beschriebenen Fälle haben einen Durchmesser von mehr als 4 cm und präsentieren sich als pT3-Tumoren (Tumorinfiltration des perirenalen oder hilären Fettgewebes).…”

Section: Makroskopie Und Histologieunclassified

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Neuroendokrine Tumoren der Niere

Moch¹

2015

Pathologe

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The 2004 World Health Organization (WHO) classification of renal cancer includes renal carcinoid and neuroendocrine cancer of the kidneys in the group of primary renal neuroendocrine tumors. The histological features of primary renal carcinoids are similar to those of neuroendocrine tumors found in other anatomical locations. Primary carcinoid tumors of the kidneys are frequently misdiagnosed as other kidney cancers, such as papillary renal cell carcinoma, mesonephric tumors, Wilms tumor (WT) and undifferentiated carcinoma. Immunohistochemical staining results are consistent with the diagnosis of a neuroendocrine tumor with immunoreactivity for synaptophysin, chromogranin, CD56, and neuron-specific enolase (NSE). Positive expression of CD99 can also be seen. There is mainly absence of WT1, cytokeratin 7, cytokeratin 20, thyroid transcription factor (TTF1) and LCA, ruling out most other differential diagnoses. Renal carcinoid tumors are regarded as low-grade neuroendocrine tumors; however, many studies have demonstrated metastatic disease in patients with renal carcinoid tumors. The prognostic value of histological parameters is uncertain. Some studies have correlated poor patient prognosis with increased mitotic activity, presence of necrosis and cytological atypia. Cases with higher mitotic rates of > 2 mitoses/10 high power fields (HPF) developed metastases more frequently; therefore, the WHO classification of neuroendocrine tumors used in other organs is recommended for primary renal carcinoid tumors.

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“…Neuroendocrine neoplasms (NENs) originate in neuroendocrine system that are present in different regions of the body, such as endocrine glands, respiratory tract (10), gastroenteropancreatic tract (13), and urogenital tract (15), among others (8,18,19).…”

Section: Introductionmentioning

confidence: 99%

Non-functional neuroendocrine tumor with multisystemic metastasis in a cat

Baeta¹,

Abreu²,

Sousa³

et al. 2021

BJVP

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An eight-year-old castrated female feline was referred for necropsy with a history of apathy, inappetence, abdominal distension, hypersensitivity to abdominal palpation, and evidence of abdominal neoplasms on ultrasound. Macroscopically, multifocal to coalescent, yellowish-white, firm and infiltrative nodules were observed on the surface of the parietal peritonium and in abdominal and thoracic organs. Microscopic characteristics of the neoplasm suggested a neuroendocrine origin, but did not allow a definitive diagnosis and determination of the origin. Immunohistochemistry revealed that neoplastic cells expressed vimentin, CD56, neuron specific enolase, and PGP 9.5 and were negative for biogenic amines and hormonal peptides. Based on anatomopathological and immunohistochemical findings, diagnosis of metastatic non-functional neuroendocrine tumor was confirmed.

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Carcinoid Tumors of the Urinary Tract and Prostate

Cited by 80 publications

References 87 publications

Natural History of Renal Neuroendocrine Neoplasms: A NET by Any Other Name?

Natural History of Renal Neuroendocrine Neoplasms: A NET by Any Other Name?

Neuroendokrine Tumoren der Niere

Non-functional neuroendocrine tumor with multisystemic metastasis in a cat

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