Carcinoid tumours of the testis

Stroosma, Otto B.; Delaere, K.P.J.

doi:10.1111/j.1464-410x.2007.07360.x

Cited by 58 publications

(73 citation statements)

References 39 publications

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“…Cases have been reported with patients ranging in age from ten to eighty-three years, which is older than that reported with most primary germ cell tumors (20-40 years) (1).…”

Section: Introductionmentioning

confidence: 77%

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Primary pure carcinoid tumors of the testis: Clinicopathological and immunophenotypical characteristics of 11 cases

Zhang

Jiang

et al. 2015

Oncology Letters

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Abstract. Primary pure carcinoid tumors of the testis (pPCTT) are rare, and there are only a limited number of studies available. In the present study we described the clinicopathological and immunophenotypical characteristics of 11 cases from our institution between 1978 and 2014, and reported our experiences of the diagnosis and treatment of these patients. The patients ranged in age from 26 to 68 years old, with a median age of 48 years. One patient (9%) was classified as pT2 and 10 (91%) were pT1. Histologically, 7 cases were diagnosed as classical carcinoid tumors, while the other 4 cases were identified as atypical carcinoid tumors. The most common growth pattern was a mixed insular, acinar, rosetted, solid and trabecular pattern. Immunohistochemical staining revealed positive expression of neuron-specific enolase in all cases, and CgA, Syn and CD56 markers in 8 (72.7%), 10 (90.9%) and 9 cases (81.7%), respectively. In addition to radical orchiectomy, 9 patients (81.7%) received a combined modality of treatment. Follow-up data were available for 8 patients. Seven were alive at the last follow-up without recurrence, and one patient succumbed to cerebral hemorrhage 7 years after surgery. In summary, localized pPCTT is a rare disease with an indolent clinical course. When a testicular carcinoid tumor is identified, a metastasis or an intestinal primary tumor should be excluded, particularly when the testicular tumor is large. A tumor size ≤6.0 cm and the histological appearance had little relation with metastatic behavior.

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“…Cases have been reported with patients ranging in age from ten to eighty-three years, which is older than that reported with most primary germ cell tumors (20-40 years) (1).…”

Section: Introductionmentioning

confidence: 77%

“…Carcinoid tumors are rare in the testis and comprise <1% of all testicular neoplasms (1). In a review of 13,715 carcinoid tumors, 9176 cases (66.9%) occurred in the gastrointestinal tract, whereas 113 cases (0.8%) occurred in the ovary, with only 8 cases (0.06%) observed in the testicle (2).…”

Section: Introductionmentioning

confidence: 99%

Primary pure carcinoid tumors of the testis: Clinicopathological and immunophenotypical characteristics of 11 cases

Zhang

Jiang

et al. 2015

Oncology Letters

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“…Primary testicular carcinoid, as was seen in the index patient, is the commonest of these three categories. Stroosma et al in their review of 62 cases, reported 44 (71%) to be primary, 6 (9.7%) to be metastases from other locations and 12 (19.4%) to arise within a teratoma [4]. In another study of 10 cases, all were found to be of testicular origin [5].…”

Section: Discussionmentioning

confidence: 97%

“…Metastases however are rare in primary testicular carcinoids. Stroosma reported metastases in 15.9% of cases of primary testicular lesions [4]. Wang et al reported metastases in none of 20 typical primary testicular cases and in 1 of 4 cases with atypical morphology [3].…”

Section: Discussionmentioning

confidence: 99%

Well Differentiated Neuroendocrine Carcinoma of the Testis in a Nigerian Male

Nz¹,

Fc²,

Dawodu³

et al. 2015

JCR

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Abstract:Testicular carcinoids are very rare tumors that account for less than 1% of all testicular neoplasms. We present the first case of a testicular carcinoid tumor in a Nigerian male who had radical orchiectomy on account of a painful left testicular mass. Histology showed a thinly encapsulated lesion composed of sheets of closely packed spindle cells having a uniform 'salt-and-pepper' chromatin pattern, and moderate pale cytoplasm within a scant dense fibrocollagenous stroma. Mitoses were scanty and necrosis absent. There was no evidence of an intratubular germ cell tumor. The lesional cells stained positive, on immunohistochemistry, for CD 56, NSE and S100, though they were negative for chromogranin A and synaptophysin. They also showed positivity for AE 1/3 in a para-nuclear dot-like fashion. There was complete negativity for CD 99, CD 117, PLAP and EMA. The cells were weakly positivity for inhibin, while CD 45 marked only a small population of lymphocytes. A diagnosis of a spindle cell type carcinoid tumour/well differentiated neuroendocrine carcinoma was made. The presence of a fibrous capsule suggested a primary testicular lesion and subsequent abdomino-pelvic CT scan showed no intra-abdominal primaries. However, investigations to rule out a focus from the lungs are yet to be done.

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“…Testicular carcinoid tumours can present in any age group starting from age of ten upto age of eighty years 2 . Most of the testicular carcinoid tumours may be with self-detected testicular mass or testicular ache as with common testicular tumours, or uncommonly with carcinoid syndrome.We report a case of primary carcinoid tumour of the testis without features of carcinoid syndrome.…”

Section: Introductionmentioning

confidence: 99%