Carcinoma Arising in Congenital Lung Cysts

Perrot, Marc de; Pache, Jean–Claude; Spiliopoulos, A.

doi:10.1055/s-2001-14284

Cited by 51 publications

(20 citation statements)

References 2 publications

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“…The overwhelming majority of BACs are not associated with congenital lung cysts; the average age at diagnosis of all BACs is 68 years. 72 Twenty-one cases of BAC have been reported in patients with CPAM type 1; 24,50,[73][74][75][76][77][78][79][80][81][82][83][84] in this group the median diagnosis age is 18 years (range 6 months to 75 years) ( Table 2). In most of these cases, the BAC was an incidental finding in a cyst resected for other reasons.…”

Section: Bronchioloalveolar Carcinoma (Bac)mentioning

confidence: 99%

Pulmonary cysts in early childhood and the risk of malignancy

Priest

Williams

Hill

et al. 2008

Pediatric Pulmonology

271

215

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Summary. Surgery for congenital and early childhood lung cysts is often dictated by symptoms such as respiratory distress, infection or pneumothorax. Asymptomatic cysts present a therapeutic dilemma: surgical intervention and ''conservative'' observation have advocates. The risk of malignancy in such cysts is considered by some an indication for surgical intervention and is reviewed in this paper. Pleuropulmonary blastoma (PPB) is the most frequent malignancy associated with childhood lung cysts. Although rare, PPB occurs predictably in certain clinical and familial situations. This unique biology of PPB can inform the cyst management decision. The earliest manifestation of PPB is a malignant lung cyst in young children, clinically and radiographically indistinguishable from benign congenital lung cysts. Histopathologic examination differentiates cystic PPB from the benign cystic variants. Surgical excision of cystic PPB (with or without chemotherapy) cures approximately 85-90% of children. If not excised, cystic PPB evolves to cystic/solid or solid high-grade sarcoma (cure rate 45-60%) by age 2-6 years. Numerous reports of ''malignancy in a congenital lung cyst'' are now understood as the characteristic progression of cystic PPB. PPB is genetically determined in many cases. Detailed family history may reveal the hallmarks of PPB in the patient or young relatives: a unique constellation of diseases including lung cysts, cystic nephroma, childhood cancers, stromal sex-chord ovarian tumors, seminomas or dysgerminomas, intestinal polyps, thyroid hyperplasias, and hamartomas. Pneumothorax and multifocal/bilateral lung cysts also characterize PPB. These diagnoses predict that a lung cyst is more likely PPB than a benign congenital cyst. Patients fitting this pattern deserve histologic diagnosis. The genetic basis for this heritable syndrome is unknown but is being actively investigated.

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Section: Bronchioloalveolar Carcinoma (Bac)mentioning

confidence: 99%

Pulmonary cysts in early childhood and the risk of malignancy

Priest

Williams

Hill

et al. 2008

Pediatric Pulmonology

271

215

View full text Add to dashboard Cite

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“…16) However, multiple studies have shown that foregut cysts (including bronchogenic cyst and esophageal cyst) in old patients may become malignant. 17) Furthermore, with the growth of bronchogenic cyst, most patients may have complications, 11) which results in complicated disease conditions and surgical difficulties. Therefore, in principle, surgical resection should be applied as early as possible for the patients even without clinical symptoms.…”

Section: Disclosure Statementmentioning

confidence: 99%

Lipoma-Like Bronchogenic Cyst in the Right Chest Sidewall: A Case Report and Literature Review

Che¹,

Zang

Zhu

et al. 2016

ATCS

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Bronchogenic cyst most commonly occurs in the mediastinum, followed by the lung. We admitted a 59-year female patient with bronchogenic cyst being uniquely located on the right chest wall of the parietal pleura. Preoperative CT scan showed a local low-density lesion on the right chest wall. The lesion was removed by the thoracoscopic surgery. During the surgical resection, the lesion was observed to be located on the right chest wall. The lesion was surrounded by adipose tissue and covered with entire parietal pleura, which looks like lipoma. Pathological examination demonstrated that the lesion was bronchogenic cyst. In addition, previously reported cases of bronchogenic cyst were reviewed, and the relevant clinical knowledge was discussed.

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“…Complications may occur, including infection, emoptysis, trachea or superior vena cava compression, intracystic haemorrhage, rupture, bronchial fistula, pneumothorax, and malignant changes, which have all been reported [9-13]. For this reason once the diagnosis of MBC is done, even if asymptomatic, surgical resection may be recommended.…”

Section: Discussionmentioning

confidence: 99%

Thoracoscopic resection of a paraaortic bronchogenic cyst

Mondello

Lentini

Familiari

et al. 2010

J Cardiothorac Surg

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Bronchogenic mediastinal cysts (BMC) represent 18% of primitive mediastinal tumors and the most frequent cystic lesions in this area. Nowadays, BMC are usually treated by VATS. However, the presence of major adhesions to vital structures is often considered as an unfavourable condition for thoracoscopic treatment. The authors report the thoracoscopic treatment of a BMC having dense adhesions to the aortic arch. Diagnosis and surgical treatment is described. Review of the literature and surgical options on this topic are discussed.

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Carcinoma Arising in Congenital Lung Cysts

Cited by 51 publications

References 2 publications

Pulmonary cysts in early childhood and the risk of malignancy

Pulmonary cysts in early childhood and the risk of malignancy

Lipoma-Like Bronchogenic Cyst in the Right Chest Sidewall: A Case Report and Literature Review

Thoracoscopic resection of a paraaortic bronchogenic cyst

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