Carcinoma Arising in Scars, Osteomyelitis, and Fistulae

Bowers, Ralph F.

doi:10.1001/archsurg.1960.01290210032006

Cited by 84 publications

(28 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[14][15][16] Free radicals are produced by phagocytes associated with inflammation, 17 and free radicals are known to invade cancer. 18,19 In this case, cancer occurred from a rectocutaneous fistula within the radiation field; therefore, the free radicals in fistulas may also cause cancer.…”

Section: Discussionmentioning

confidence: 99%

Radiation-Induced Rectal Cancer Originating from a Rectocutaneous Fistula: Report of a Case

et al. 2004

View full text Add to dashboard Cite

This report describes a patient with radiation-induced rectal cancer with an unusual history. A 51-year-old man was admitted in 2000 because of ichorrhea of the skin on the left loin. The patient had received irradiation for a suspicious diagnosis of a malignant tumor in the pelvic cavity in 1975. A subcutaneous abscess in the right loin appeared in 1989, and rectocutaneous fistula was noted in 1992. Moreover, radiation-induced rectal cancer developed in 2000. Plain computed tomography and magnetic resonance imaging of the pelvis demonstrated a presacral mass and tumor in the rectum. Finally, we diagnosed the presacral mass to be an abscess attached to the center of the rectal cancer. The rectum was resected by Miles' operation and a colostomy of the sigmoid colon was also performed. Many cases of radiation-induced rectal cancer have been reported. However, this is a rare case of radiation-induced rectal cancer originating from a presacral abscess and rectocutaneous fistula.

show abstract

Section: Discussionmentioning

confidence: 99%

Radiation-Induced Rectal Cancer Originating from a Rectocutaneous Fistula: Report of a Case

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Although neoplastic changes in chronically ulcerating wounds were first identified by Celsus in the first century A.D., 1 French surgeon Jean-Nicolas Marjolin, in the classic 1828 essay entitled "Ulcere," first used the term "ulcers canceroides." His description has endured, and this syndrome still bears Marjolin's name.…”

mentioning

confidence: 99%

Sentinel Lymph Node Biopsy Identifies Occult Nodal Metastases in Patients with Marjolin's Ulcer

Eastman

Erdman

Lindberg

et al. 2004

The Journal of Burn Care &Amp; Rehabilitation

View full text Add to dashboard Cite

Since Marjolin's description, the management of burn scar carcinoma has remained controversial. A multitude of options and recommendations exist for the management of both primary lesions and regional nodal metastasis. This work reviews six cases of Marjolin's ulcer staged using sentinel lymph node biopsy. All primary lesions were confirmed to be squamous cell carcinoma and occurred a median of 29.5 years after burn. No patient had clinically detectable lymphadenopathy. In all cases, preoperative lymphoscintigraphy successfully identified a single draining regional nodal basin. Subsequent intraoperative lymphatic mapping/sentinel lymph node (SLN) biopsy was successful in five of six cases (83%). A successful intraoperative lymphatic mapping/SLN biopsy was defined as the identification of blue (uptake of isosulfan blue dye) or "hot" (uptake of radiolabeled sulfur colloid as measured with a handheld gamma counter) node(s) and subsequent excision. Four of five SLN biopsies identified previously occult nodal metastasis. SLN biopsy represents a minimally invasive and accurate staging procedure for Marjolin's ulcer.

show abstract

“…Development of squamous cell carcinoma has been associated with chronic nonhealing wounds due to burns, venous stasis ulcers, and chronic infections [11][12][13]. Malignant degeneration is the final pathophysiologic step in the natural history of a chronic wound that develops into cancer.…”

Section: Discussionmentioning

confidence: 99%