Carcinoma Arising in the Pancreas 17 Years After Primary Excision of a Choledochal Cyst: Report of a Case

Eriguchi, Naofumi; Aoyagi, Shigeaki; Okuda, K; Hara, Masao; Fukuda, Shuichi; Tamae, Tsuyoshi; Kanazawa, Naomitsu; Jimi, Atsuo

doi:10.1007/s005950170117

Cited by 26 publications

(12 citation statements)

References 15 publications

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“…There have been some case reports of patients with CDB in whom cancer developed in the bile duct remnant at the distal end of a cystic-dilated extrahepatic duct after the resection of an extrahepatic bile duct. Eriguchi et al 11 reported such a case that developed 17 years after the excision of a choledochal cyst. Kurokawa et al 12 reported a patient who developed cancer of the pancreatic head 3 years after the excision of a choledochal cyst, as well as referring to four other reported cases that developed cancer after the excision of a choledochal cyst.…”

Section: Discussionmentioning

confidence: 96%

Abnormal arrangement of the pancreato-biliary ductal system associated with advanced gallbladder cancer diagnosed 3 years after follow-up ultrasonography

Fujita

Noda

Kobayashi

et al. 2003

Journal of Gastroenterology

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We herein report a case of abnormal arrangement of the pancreato-biliary ductal system (AAPB) followed by advanced gallbladder cancer 9 years after the initial endoscopic retrograde cholangiopancreatography (ERCP) diagnosis and almost 3 years after follow-up ultrasonography (US). A 65-year-old woman was referred to our department from a private clinic because of difficulty in controlling her diabetes mellitus. The patient had no complaints, and physical examination revealed no jaundice in her skin or conjunctiva. ERCP demonstrated the presence of AAPB (bile duct-main type) without congenital dilatation of the bile duct or irregularity in the gallbladder wall. She did not wish to undergo cholecystectomy. Follow-up transabdominal US revealed no change in the gallbladder. Two years and 9 months after this US examination, she developed advanced gallbladder cancer involving the liver and bile duct, with paraaortic lymph node metastases confirmed by US, computed tomography, and ERCP. This case re-emphasizes the necessity for patients with AAPB to undergo intensive follow-up examinations or cholecystectomy when the diagnosis of AAPB has been established.

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Section: Discussionmentioning

confidence: 96%

Abnormal arrangement of the pancreato-biliary ductal system associated with advanced gallbladder cancer diagnosed 3 years after follow-up ultrasonography

Fujita

Noda

Kobayashi

et al. 2003

Journal of Gastroenterology

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“…Reports on cholangiocarcinoma derived from remnant intrapancreatic bile duct are rare. To the best of our knowledge, there are only 6 other reported cases, which include 1 man and 5 women (average age: 42.7 years, range: 27-68; table 2) [4,[7][8][9][10][11], and all of these patients underwent surgery for intrapancreatic cholangiocarcinoma. Four of 6 cases had postoperative mortality after a short term of 9-16 months (average: 12.3 months).…”

Section: Discussionmentioning

confidence: 99%

Cholangiocarcinoma Derived from Remnant Intrapancreatic Bile Duct Arising 32 Years after Congenital Choledochal Cyst Excision: A Case Report

Ishikawa¹,

Ogasawar²,

Chiba³

et al. 2015

Case Rep Oncol

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We report a rare case of a 46-year-old woman with cholangiocarcinoma derived from remnant intrapancreatic bile duct arising 32 years after the excision of a congenital choledochal cyst. She had undergone anastomosis of the choledochal cyst and duodenum at birth, excision of the choledochal cyst and hepaticoduodenostomy with jejunal interposition at 14 years of age as well as the excision of an infectious cyst around the anastomosis site at 21 years of age. At 29 years of age, she was diagnosed with a chronic hepatitis C virus (HCV) infection and was referred to our hospital for treatment. She did not consent to interferon-based therapy against the HCV infection. At 46 years of age, she experienced epigastric discomfort. A dynamic CT revealed multiple tumors in the liver, a tumor in the head of the pancreas as well as lymph node metastases in the mediastinum and abdominal cavity. A liver tumor biopsy revealed adenocarcinoma, and she was clinically diagnosed with cholangiocarcinoma derived from remnant intrapancreatic bile duct with multiple metastasis in the liver and lymph node metastasis. She requested palliative therapy and eventually died during the treatment course. The autopsy specimen revealed a tumor in the head of the pancreas, and on the basis of local existence and the pattern of metastasis, it was confirmed as cholangiocarcinoma derived from remnant intrapancreatic bile duct. A microscopic examination revealed a poorly differentiated adenocarcinoma. This report provides information on a case of cholangiocarcinoma derived from remnant intrapancreatic bile duct arising after the excision of congenital choledochal cyst that was assessed pathologically.

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“…Numerous reports of malignant transformation in the bile duct, both proximal and distal, after cyst excision, even many years after initial treatment, were published, which outline the importance of long term follow-up [70][71][72][73][74][75]. Long-term survival in patients, who developed malignancy is rare and equals that of the general population with cholangiocarcinoma [63,76].…”

Section: Outcome and Prognosismentioning

confidence: 99%

Recent developments in the diagnosis and treatment of bile duct cysts: a review

et al. 2011

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Carcinoma Arising in the Pancreas 17 Years After Primary Excision of a Choledochal Cyst: Report of a Case

Cited by 26 publications

References 15 publications

Abnormal arrangement of the pancreato-biliary ductal system associated with advanced gallbladder cancer diagnosed 3 years after follow-up ultrasonography

Abnormal arrangement of the pancreato-biliary ductal system associated with advanced gallbladder cancer diagnosed 3 years after follow-up ultrasonography

Cholangiocarcinoma Derived from Remnant Intrapancreatic Bile Duct Arising 32 Years after Congenital Choledochal Cyst Excision: A Case Report

Recent developments in the diagnosis and treatment of bile duct cysts: a review

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