Carcinoma arising in thyroglossal remnants

Vuuren, P. A. van; Balm, A. J. M.; Gregor, R. T.; Hilgers, F. J. M.; Loftus, B. M.; Delprat, C.C.; Rutgers, E.J.T.

doi:10.1111/j.1365-2273.1994.tb01279.x

Cited by 65 publications

(32 citation statements)

References 36 publications

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“…Unlike nonneoplastic TGDCs, which show no gender predilection [2][3][4], TGDCCa affect women more frequently than men with a 3:1 female to male ratio observed in the present series, or 2.3:1 overall when including the literature ( Most patients present with a mobile midline neck mass, clinically indistinguishable from benign TGDC [2,13,17,[19][20][21]. The finding of a fixed mass has been emphasized as a possible indicator of malignancy [3,20,36], but was present in only 2 patients in this series.…”

Section: Discussionmentioning

confidence: 78%

“…TGDCCa are thought to represent primary neoplasms arising from ectopic thyroid gland tissue commonly found in TGDCs [7,9,[17][18][19][20][21]. There is, however, theoretic consideration that these tumors may represent metastases from a primary carcinoma of the thyroid gland [50].…”

Section: Discussionmentioning

confidence: 99%

“…The reported incidence of carcinoma occurring in TGDCs ranges from \1 to 19.6 % [5][6][7][8][9][10][11][12][13][14][15][16], although probably more in the 2 % range when referral and academic bias are removed from consideration [4]. The vast majority of TGDC carcinomas (TGDCCa) are papillary thyroid carcinomas (PTCs), thought to originate from the ectopic thyroid gland tissue which is commonly (approximately 70 % of cases) found in association with TGDCs [2,4,7,9,[16][17][18][19][20][21][22]. The clinical presentation of TGDCCa do not differ significantly from that of nonneoplastic TGDC, although a fixed mass is worrisome, with most cases of malignancy diagnosed postoperatively following pathologic evaluation of the lesion [2,17,20,21].…”

Section: Introductionmentioning

confidence: 99%

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Thyroglossal Duct Cyst Carcinomas: A Clinicopathologic Series of 22 Cases with Staging Recommendations

Thompson

Herrera

Lau³

2016

Head and Neck Pathol

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Carcinomas arising from thyroglossal duct remnant cysts (TGDCs) are rare, without well-defined management and staging criteria. All TGDCs (n = 685) diagnosed between 2005 and 2015 were retrospectively reviewed, with 22 carcinomas identified (3.2 % incidence). Twenty-two patients (17 females, 5 males), aged 12-64 years (mean 39.9 years; median 39 years) were identified. An anterior, superior midline neck mass was the presenting symptom in all patients. A cancer diagnosis [all papillary thyroid carcinoma (PTC)] was made after the Sistrunk procedure (SP), with a Bethesda Category V or VI classification preoperatively by fine needle aspiration in 5 of 12 cases tested. A SP was performed in all patients, with total thyroidectomy concurrently (n = 4) or subsequently (n = 12). A selected neck dissection was performed in 5 patients, with metastases found in 3. Of the patients who had a thyroidectomy, syn-

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thyroglossal Duct Cyst Carcinomas: A Clinicopathologic Series of 22 Cases with Staging Recommendations

Thompson

Herrera

Lau³

2016

Head and Neck Pathol

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“…The incidence of carcinoma of TGDC is less than 1% [21][22][23]. There is still controversy about thyroid removal for a papillary carcinoma of TGDC.…”

Section: Discussionmentioning

confidence: 99%

Management of Thyroglossal Duct Cyst

Swaid¹,

Alammar²

2008

TOOTORJ

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Abstrct:Objective: Is to review our cases of Thyroglossal duct cyst (TGDC) attempting to make some conclusions that may facilitate the management of such a cases.Study Design: Twenty patients with the diagnosis of TGDC were managed between July 1996 and April 2007 in the department of Otolaryngology, King Abdul-Aziz University Hospital, Riyadh, Saudi Arabia.Results: All of our cases underwent radiological assessment before surgical intervention. Eighteen patients underwent Sistrunk procedure. In two patients the treatment was limited to removal of the cyst. In seventeen patients the clinicoradiological diagnosis was in agreement with histopathological diagnosis of TGDC. Conclusions:The diagnosis of TGDC in most of the cases is clinical. Combination of clinical assessment and imaging studies can improve the sensitivity for the diagnosis. Sistrunk's operation presented good results in our series with low rates of complications (5%) and recurrence (5.5%).

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“…There is slightly more female: male ratio of 1.6: 1 [9]. The size of the mass is variable, but most are in the 1.2-5 cm range [10].…”

Section: Case Reportmentioning

confidence: 99%

Dilemma in Managing Thyroglossal Duct Cyst Carcinoma

Sadia¹,

Prashant²,

E³

et al. 2016

Glob J Rare Dis

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The thyroglossal duct cyst (TGDC) is a well-known developmental abnormality encountered in the neck. It represents over 75% of childhood midline neck masses and 7% of the adult population. It typically presents as a mobile, painless mass in the anterior midline of the neck, usually in close junction to the hyoid bone. TGDCs infrequently present with signs and symptoms of secondary infection, or with evidence of a fi stula. Malignancy is rarely encountered in TGDCs approximately in 1.5% of patients. We present an interesting and rare case of elderly female who presented with an asymptomatic neck mass. CT scan of neck with contrast showed lobulated vascular enhancing mass 3.1 cm in size with no signifi cant lymphadenopathy. Fine needle aspiration of neck mass revealed papillary carcinoma. She underwent Sistrunk procedure with total thyroidectomy and central neck dissection followed by radioactive iodine (RAI) and thyroid hormone suppression. Since the incidence of TGDC carcinoma is low, controversy exists in its management in relation to type and the extent of surgery and use of RAI.

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Carcinoma arising in thyroglossal remnants

Cited by 65 publications

References 36 publications

Thyroglossal Duct Cyst Carcinomas: A Clinicopathologic Series of 22 Cases with Staging Recommendations

Thyroglossal Duct Cyst Carcinomas: A Clinicopathologic Series of 22 Cases with Staging Recommendations

Management of Thyroglossal Duct Cyst

Dilemma in Managing Thyroglossal Duct Cyst Carcinoma

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