Carcinoma Asociated With Idiopathic Choledochus Cyst

Abstract

Clinical and autopsy findings of a rare condition, carcinoma arising in the wall of an idiopathic choledochus cyst, are reported. Endogeneous carcinogen which is likely to be present in the bile, and coexisting chronic inflammation in the wall of the cyst are assumed to be significant causative factors for the development of carcinoma. The possibility of dysontogenetic development of carcinoma was also discussed.

Biliary tract malignancy and abnormal pancreaticobiliary junction in a Western population

“…According to Kimoura’s classification the mode of APBJ can be divided into two types: Type I, where the main pancreatic duct enters the common bile duct; and Type II, where the common bile duct enters the pancreatic duct. There is evidence that the type of union may play a role in the carcinogenesis 10,11 …”

“…There is evidence that the type of union may play a role in the carcinogenesis. 10,11 To assess the APBJ frequency in Western populations and its association with biliary tract malignancies, we retrospectively analyzed the endoscopic retrograde cholangiopancreatography (ERCP) examinations of 82 consecutive patients with cholangiocarcinoma or gallbladder cancer and 220 patients with normal or non-malignant biliary disease treated at Baylor University Medical Center.…”