Carcinoma Associated with Anal Fistula: A Clinicopathologics Study in 15 Patients

Kobayashi, Akihiro; Koda, Takamaru; Minagawa, Nozomi; Nishizawa, Yusuke; Ito, Masaaki; Sugito, Masanori; Kojima, Masaru; Saitô, Norio

doi:10.3862/jcoloproctology.63.346

Cited by 9 publications

(8 citation statements)

References 41 publications

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“…Nakajima et al . reported that the 5‐year survival rates of patients with curative and non‐curative resection were 74 and 16%, respectively. The higher incidence of noncurative resection was because of significant inflammation associated with the chronic fistula, which makes it difficult to precisely define the extent of the disease.…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary management of colorectal adenocarcinoma associated with anal fistula: an Indian series

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Multidisciplinary management of colorectal adenocarcinoma associated with anal fistula: an Indian series

et al. 2015

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“…Operation and abdominoperineal resection was reportedly mainly performed in 15 patients with anal fistula cancer. [ 6 ] Furthermore, the protocol for chemotherapy is not established. There are some reports on the effects of chemotherapy and pathological type of colon cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Tubular adenocarcinomas are expected to respond to chemoradiotherapy, whereas the mucinous ones are resistant to these therapies. [ 6 , 9 , 10 ] Therefore, determining the histopathology of an anal fistula cancer before treatment is critical.…”

Section: Introductionmentioning

confidence: 99%

Value of apparent diffusion coefficient on MRI for prediction of histopathological type in anal fistula cancer

et al. 2023

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The main histopathological types of anal fistula cancers are mucinous adenocarcinoma and tubular adenocarcinoma. The purpose of this study was to investigate the utility of the apparent diffusion coefficient (ADC) value in magnetic resonance imaging (MRI) to determine the histopathological type of an anal fistula cancer, and to investigate the relationship between ADC values and histopathological type (mucinous type or tubular carcinoma), clinical information, and surgical findings. We retrospectively identified 69 patients diagnosed with anal fistula cancer at our hospital from January 2013 to December 2021. Among them, we selected the patients diagnosed using the same 1.5-T MRI machine, underwent surgery, and a pathological sample was obtained during the operation. Finally, these 25 patients were selected for the analysis since they underwent the imaging scan using the same MRI machine. The ADC value was compared between mucinous and tubular adenocarcinomas, and between tumors at the Tis-T1-T2 and T3-T4 stages. Finally, 25 patients were selected. The mean age of the 25 patients included in the analysis was 60.8 ± 13.3 years and all were males. The median ADC of anal fistula cancers was 1.97 × 10 –3 mm 2 /s for mucinous adenocarcinomas and 1.36 × 10 –3 mm 2 /s for tubular adenocarcinomas; this difference was statistically significant ( P < .01). Furthermore, the median ADC was 1.62 × 10 –3 mm 2 /s for tumors in Tis-T1-T2 stages and 2.01 × 10 –3 mm 2 /s for T3-T4 tumors ( P = .02). The ADC value in MR images may predict the histopathological type and depth of anal fistula cancers. Also, the different ADC values between Tis-T1-T2 and T3-T4 tumors could help predict the classification of progression.

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“…NCCN guidelines recommend neoadjuvant chemoradiotherapy followed by TME as the standard treatment for locally advanced adenocarcinoma of rectum irrespective of histological subtype [13]. Nekajima et al reported a 5-year survival of 74% and 16% for those that received curative and non-curative surgery, respectively [14]. Locally, the division of colorectal surgery at Tata Memorial hospital have published their experience in a retrospective study by V. D. Pai et al, that reported management of locally advanced ACAF with the administration of NACRT, routine use of MRI to stage the patient before surgery, and ELAPE with reconstruction surgery by a V-Y advancement flap as shown in, with good results [8].…”

Section: Discussionmentioning

confidence: 99%

Mucinous Adenocarcinoma Associated with Fistula in an 87-Year-Old Managed with Neoadjuvant Chemoradiation and ELAPE at Tata Memorial Hospital, in Mumbai

Kazuma¹,

Sukumar²,

Saklani³

2020

GSCR

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Colorectal cancer is the third most diagnosed cancer and the fourth leading cancer-related death worldwide. Mucinous adenocarcinoma associated with anal fistula is a rare variant of adenocarcinoma, presents with delayed diagnosis, locally advanced, low nodal, and no distant metastasis. Adenocarcinoma associated with fistula (ACAF) is rare, has delayed diagnosis and poor prognosis but can be managed with neoadjuvant chemoradiation (NACRT) and complete curative resections with reconstruction by V-Y advancement cutaneous flap.

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Carcinoma Associated with Anal Fistula: A Clinicopathologics Study in 15 Patients

Cited by 9 publications

References 41 publications

Multidisciplinary management of colorectal adenocarcinoma associated with anal fistula: an Indian series

Multidisciplinary management of colorectal adenocarcinoma associated with anal fistula: an Indian series

Value of apparent diffusion coefficient on MRI for prediction of histopathological type in anal fistula cancer

Mucinous Adenocarcinoma Associated with Fistula in an 87-Year-Old Managed with Neoadjuvant Chemoradiation and ELAPE at Tata Memorial Hospital, in Mumbai

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