Carcinoma de células renales del túbulo colector

Husillos, A.; Herranz-Amo, F.; Subirá, D.; Lledó, E.; Molina-Escudero, R.; Hernández-Fernández, C.

doi:10.1016/j.acuro.2011.01.012

Cited by 11 publications

(2 citation statements)

References 9 publications

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“…The understanding of the CdC is still insufficient. it is a disease with poor prognosis, survival and response to target therapies 3,14 . The cases reported in this paper could contribute to deeper understanding of the rare CdC entity.…”

Section: Discussionmentioning

confidence: 99%

Collecting Duct Carcinoma and Endemic Nephropathy – Case Reports and Literature Review

Knežević

Tomić

Dittrich

et al. 2020

ACC

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Although collecting duct carcinoma is a subtype of renal cell carcinoma, several studies implicate association with urothelial carcinoma. The coexistence of collecting duct carcinoma and another renal neoplasm is rare. endemic nephropathy is a renal disease causing chronic renal failure. it is highly associated with urothelial neoplasm and occurs in endemic villages in Bosnia, Croatia, Bulgaria, Romania and serbia. Recent studies have confirmed the important role of exposure to aristolochic acid as an etiologic factor. we present three cases of collecting duct carcinoma with literature overview. in one case, we describe collecting duct carcinoma with metachronous urothelial carcinoma of the pyelon and urinary bladder in an endemic nephropathy patient. to our knowledge, this is the first case report describing this coexistence. Certain similarities between collecting duct carcinoma and urothelial carcinoma were found, e.g., higher incidence in female compared to male, higher mean age, and multifocal and multicentric occurrence of the tumor. our observations support the hypothesis that collecting duct carcinoma and urothelial carcinoma could be connected.

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Section: Discussionmentioning

confidence: 99%

Collecting Duct Carcinoma and Endemic Nephropathy – Case Reports and Literature Review

Knežević

Tomić

Dittrich

et al. 2020

ACC

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“…In a recent Spanish series of 6 patients, none of these treatmentsappearedtobeeffective [14],andthemediansurvival wasonly5.5monthswithonly2patients,bothwithlocalized disease at diagnosis, surviving for longer than 1 year . In a retrospectiveanalysisof7cases [5],4patientsreceivedfirst-line treatment with sorafenib, 1 with sunitinib and 2 with temsirolimus, and following progression 2 patients received second-line treatment with sunitinib.…”

Section: Discussionmentioning

confidence: 99%

HER2 Blockade in Metastatic Collecting Duct Carcinoma (CDC) of the Kidney: A Case Report

Bronchud¹,

Castillo²,

Romaní³

et al. 2012

Onkologie

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Background: Collecting duct carcinoma of the kidney (CDC) is a rare cancer associated with bad prognosis and, at present, with no specific effective therapies. Case Report: We report a clinical case with disseminated highgrade CDC presenting with widespread metastasis to both lungs, pelvic bones, axial skeleton, and the central nervous system (posterior fossa, both hemispheres and pituitary-hypothalamic). The primary tumor in the kidney was demonstrated (by fluorescence in situ hybridization and immunohistochemistry with Herceptest (3+ score)) to significantly overexpress HER2. Critically ill at presentation, the patient received oral capecitabine together with double HER2 blockade with both intravenous trastuzumab and oral lapatinib. His clinical response was a dramatic improvement and a progressive decline in the radiological size of all of his multiple cancer lesions. Conclusion: Double HER2 blockade is an effective therapy in disseminated CDC even in the presence of brain metastases.

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Respuesta del Director: la evidencia de los casos clínicos en Urología es, en sí misma, escasamente defendible

Angulo

2012

Actas Urológicas Españolas

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Carcinoma de células renales del túbulo colector

Cited by 11 publications

References 9 publications

Collecting Duct Carcinoma and Endemic Nephropathy – Case Reports and Literature Review

Collecting Duct Carcinoma and Endemic Nephropathy – Case Reports and Literature Review

HER2 Blockade in Metastatic Collecting Duct Carcinoma (CDC) of the Kidney: A Case Report

Respuesta del Director: la evidencia de los casos clínicos en Urología es, en sí misma, escasamente defendible

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