Carcinoma de tiroides incidental versus no incidental: presentación clínica, tratamiento quirúrgico y pronóstico

González-Sánchez-Migallón, Elena; Flores-Pastor, Benito; Pérez-Guarinos, Carmen Victoria; Miguel-Perelló, Joana; Cháves-Benito, Asunción; Illán-Gómez, Fátima; Carrillo-Alcaraz, Andrés; Aguayo-Albasini, José Luís

doi:10.1016/j.endonu.2016.05.009

Cited by 19 publications

(1 citation statement)

References 20 publications

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“…González-Sánchez-Migallón et al [29] Incidental histological: Malignant neoplasms of thyroid origin, not detected clinically or by preoperative imaging tests, and that are evidenced in the pathological study of the surgical piece removed by an a priori benign process (goiter or hyperthyroidism). Non-incidental: When the diagnosis of thyroid cancer was established based on clinical, ultrasound, and fine needle aspiration cytology.…”

Section: Not Reportedmentioning

confidence: 99%

Triggers of thyroid cancer diagnosis: a systematic review and meta-analysis

et al. 2021

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Purpose Understanding the method of thyroid cancer detection has potential implications on interpreting incidence rates, the diagnosis and management of thyroid cancer. We conducted a systematic review of studies reporting methods of thyroid cancer detection to estimate the frequency of incidentally found cancers and classify triggers of incidental thyroid cancer diagnosis. Methods We searched multiple bibliographic databases from inception to June 2020. A pair of reviewers, working independently and in duplicate selected studies for inclusion, extracted data, and evaluated each trial's risk of bias. Studies enrolling patients older than 18 years with thyroid cancer confirmed histologically were included. Results In total, 17 cohorts and 1 cross-sectional study, conducted between 1991 and 2018, enrolling 4668 patients with thyroid cancer were included: 88% had papillary thyroid cancer and 23% had papillary thyroid microcarcinoma. The proportion of patients with non-incidental and incidental thyroid cancer was similar: 49% [95% confidence interval (CI): 40-58%]. Subgroup analysis showed that most patients with incidental thyroid cancers had tumor size <10 mm (76%; 95% CI: 56-92%), age >45 (61%; 95% CI: 56-67%), and were detected through imaging (35%; 95% CI: 26-45%), of which ultrasound was the most common modality (27%; 95% CI: 14-43%). The heterogeneity for all the effect sizes was large and significant. Conclusions About half of thyroid cancers were found incidentally through the use of imaging studies, in particular neck ultrasound. These incidentally found cancers were mostly small papillary thyroid cancer. These results highlight opportunities for interventions aimed at reducing drivers of overdiagnosis.

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Section: Not Reportedmentioning

confidence: 99%

Triggers of thyroid cancer diagnosis: a systematic review and meta-analysis

et al. 2021

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Effect of Graves’ disease on the prognosis of differentiated thyroid carcinoma: a meta-analysis

Song

Wang

et al. 2019

Endocrine

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Incidental thyroid carcinoma in an endemic goiter area in Italy: histopathological features and predictors of a common finding

Chiefari,

Innaro,

Gervasi

et al. 2024

Endocrine

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Purpose The occurrence and histopathological features of incidental thyroid carcinoma (ITC) vary considerably among populations from different geographical regions. The aim of this study is to assess the prevalence and histopathological characteristics of ITC in patients who underwent thyroid surgery for apparently benign thyroid diseases in an endemic goiter area in Italy. Methods A total of 649 consecutive patients (531 females and 118 males; mean age, 52.9 ± 11.0 years), who underwent thyroid surgery at the Endocrine Surgery Unit of the tertiary care “Renato Dulbecco” University Hospital (Catanzaro, Italy) in the period between years 2017 and 2022, were included in this retrospective study. A comprehensive histopathological examination was performed on surgically excised thyroid tissue. Logistic regression analysis was employed to identify potential predictors of ITC. Results The histopathological examination revealed the presence of ITC in 81 patients, accounting for 12.5% of the total study population. The female to male ratio was found to be 6.4 to 1. Among the patients with ITC, 72 had papillary carcinoma (PTC), with 53 of these tumors being microcarcinomas (microPTC). Additionally, 5 patients had follicular thyroid carcinoma, 2 patients had low-risk follicular cell-derived thyroid neoplasms, 1 patient had an oncocytic carcinoma, and 1 patient had a medullary thyroid carcinoma. Logistic regression analysis demonstrated a significant association between female sex and incidental microPTC. Conclusions These findings provide further evidence of the common occurrence of ITC, typically in the form of microPTC, among individuals who undergo thyroid surgery for apparently benign thyroid diseases.

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Carcinoma de tiroides incidental versus no incidental: presentación clínica, tratamiento quirúrgico y pronóstico

Cited by 19 publications

References 20 publications

Triggers of thyroid cancer diagnosis: a systematic review and meta-analysis

Triggers of thyroid cancer diagnosis: a systematic review and meta-analysis

Effect of Graves’ disease on the prognosis of differentiated thyroid carcinoma: a meta-analysis

Incidental thyroid carcinoma in an endemic goiter area in Italy: histopathological features and predictors of a common finding

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