Carcinoma ex pleomorphic adenoma of the parotid gland: a multi-institutional retrospective analysis in the Northern Japan Head and Neck Cancer Society

Suzuki, Masahiro; Matsuzuka, Takashi; Saijo, Satoshi; Takahara, Miki; Harabuchi, Yasuaki; Okuni, Tsuyoshi; Himi, Tetsuo; Kakizaki, Tomohiko; Fukuda, Satoshi; Yamada, Kazuyuki; Nagahashi, Tatsumi; Abe, Takahisa; Shinkawa, Hideichi; Katagiri, Ken; Sato, Hiroaki; Fukui, Naoko; Ishikawa, Kazuo; Suzuki, Takahiro; Kobayashi, Toshimitsu; Saito, Daisuke; Saijo, Shigeru; Tateda, Masaru; Hashimoto, Sho; Ishida, Akihiro; Kakehata, Seiji; Сузукі, Осаму; Hashimoto, Yuko; Omori, Koichi

doi:10.1080/00016489.2016.1191671

Cited by 23 publications

(17 citation statements)

References 19 publications

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“…Not surprisingly, a previous research effort addressed that the mean age of CXPA is 61 years, 5 and another study with smaller number of patients showed that the median age of CXPA is 60 years. 11 Our study showed that the average was slightly lower (55.1 years old) than these previous studies. When compared to pleomorphic adenoma, the mean age of diagnosis was significantly different by approximately 13 years ( Figure 1A, 55.1 vs 42.3, respectively, P ¼ .001).…”

Section: Comparison With Other Studiescontrasting

confidence: 68%

The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma

et al. 2019

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Carcinoma ex pleomorphic adenoma (CXPA) arises from the primary or recurrent benign pleomorphic adenoma. The purpose of this study was to evaluate the clinical features that could be referenced in the differentiation. The medical records of 221 patients with pleomorphic adenoma and 15 patients with CXPA were retrospectively reviewed. Clinical characteristics, computed tomography and magnetic resonance imaging findings, and surgical pathology were analyzed. Patients with CXPA were older (55.1 vs 42.3; P < .01). Carcinoma ex pleomorphic adenoma was observed at higher rates in the minor salivary glands (24.9% vs 2.7%) and higher incidence of regional lymph node enlargement ( P = .04). While all CXPA showed a low-to-intermediate mean apparent diffusion coefficient value (ADC), most of pleomorphic adenoma had an intermediate-to-high ( P = .01). From this study, the following features should be considered as the clinical features of CXPA: (1) old age; (2) minor salivary gland tumor; (3) regional lymph node enlargement (>5 mm); and (4) low ADC findings.

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Section: Comparison With Other Studiescontrasting

confidence: 68%

The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma

et al. 2019

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“…The authors showed that CA-xPA is a more aggressive cancer compared to primary parotid cancer. The extent of CAxPA occurred significant in prognosis.. Suzuki et al demonstrated 3-year disease free survival for non-invasive CAxPA at a level of 79.9% and 76%, respectively for histopathological types of ductal carcinoma and adenocarcinoma [24]. In the same work, the percentage of recurrance--free survival for invasive forms of both CAxPA types was 60% and 30%, respectively.…”

Section: Discussionmentioning

confidence: 91%

Malignant transformation of the salivary gland pleomorphic adenoma in myoepithelial carcinoma – the report of two cases

Szabelska¹,

Rzepakowska

Szczepankiewicz

et al. 2019

Pol Otorhino Rev

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A multiform adenoma is the most commonly diagnosed benign tumor of the salivary glands. In the majority of patients, surgical resection of the tumor with the adequate surrounding tissue of salivary gland allows for complete recovery. A small percentage of the cases is a recurring pleomorphic adenoma. Even more rarely the diagnosis of carcinoma ex pleomorphic adenoma is made. The study presents two clinical cases of the malignant transformation of pleomorphic adenoma into the myoepithelial carcinoma. The surgical treatment and additional radiotherapy were performed in both cases.

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“…Historical reports list 5-year survivals ranging from 30% to 70% 4 . The tumour often arises from the background of a recurrent pleomorphic adenoma and can be composed of various histologic subtypes, including high-grade salivary duct carcinoma, adenocarcinoma not otherwise specified, myoepithelial carcinoma, and sarcomatoid carcinoma, among others 2 .…”

Section: Discussionmentioning

confidence: 99%

Carcinoma Ex Pleomorphic Adenoma: Case Report and Options for Systemic Therapy

Chooback

Shen²,

Jones³

et al. 2017

Current Oncology

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The most common benign salivary tumour is a pleomorphic adenoma. Transformation to malignancy, carcinoma ex pleomorphic adenoma (cxpa), occurs in 6% of cases. Management focuses on surgical resection and radiotherapy; however, rare cases require systemic management. We present the case of a 60-year-old woman with a cxpa of the left parotid gland who required systemic therapy for locally recurrent disease. Treatment options were guided by the literature concerning malignant salivary gland tumour and by whole-genome and transcriptome sequencing of the tumour. The patient received multiple systemic agents during the course of her disease, with cyclophosphamide-doxorubicin-cisplatin providing the best control (partial response). Genomeand transcriptome-directed therapy, including sorafenib and vismodegib, were utilized with limited clinical benefit. Malignant transformation in cxpa is a complex process, and therapy directed at a single tumour pathway might not be sufficient to control disease.

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Carcinoma ex pleomorphic adenoma of the parotid gland: a multi-institutional retrospective analysis in the Northern Japan Head and Neck Cancer Society

Cited by 23 publications

References 19 publications

The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma

The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma

Malignant transformation of the salivary gland pleomorphic adenoma in myoepithelial carcinoma – the report of two cases

Carcinoma Ex Pleomorphic Adenoma: Case Report and Options for Systemic Therapy

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