Carcinoma-in-situ and Dysplasia of the Cervix*

Gray, Laman A.; Barnes, Malcolm L.; Lee, Joseph

doi:10.1097/00000658-196006000-00019

Cited by 6 publications

(2 citation statements)

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“…A persistent HPV infection over time, gradual worsening of the lesions, viral load, tissue composition at the site of viral integration, and multiple reinfections are associated with the development of high grade squamous intraepithelial lesion (HSIL), or cervical intraepithelial neoplasia stage 2 and 3 (CIN2 and CIN3) and further, cancer in situ (CIS) [16]. These stages are together termed as high-grade dysplasia and can progress into carcinoma or invasive cervical cancer [6,17,18] (Figure 1). Although all high-risk human papillomaviruses predispose a woman to cervical cancer, there are notable differences between them.…”

Section: Hpv-associated Pathogenesismentioning

confidence: 99%

Genomic Risk Factors for Cervical Cancer

Ramachandran

Dörk

2021

Cancers

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Cervical cancer is the fourth common cancer amongst women worldwide. Infection by high-risk human papilloma virus is necessary in most cases, but not sufficient to develop invasive cervical cancer. Despite a predicted genetic heritability in the range of other gynaecological cancers, only few genomic susceptibility loci have been identified thus far. Various case-control association studies have found corroborative evidence for several independent risk variants at the 6p21.3 locus (HLA), while many reports of associations with variants outside the HLA region remain to be validated in other cohorts. Here, we review cervical cancer susceptibility variants arising from recent genome-wide association studies and meta-analysis in large cohorts and propose 2q14 (PAX8), 17q12 (GSDMB), and 5p15.33 (CLPTM1L) as consistently replicated non-HLA cervical cancer susceptibility loci. We further discuss the available evidence for these loci, knowledge gaps, future perspectives, and the potential impact of these findings on precision medicine strategies to combat cervical cancer.

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Section: Hpv-associated Pathogenesismentioning

confidence: 99%

Genomic Risk Factors for Cervical Cancer

Ramachandran

Dörk

2021

Cancers

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Section: Hpv-associated Pathogenesismentioning

confidence: 99%

Genomic Risk Factors for Cervical Cancer

Ramachandran¹,

Dörk²

2021

Preprint

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Cervical cancer is the fourth common cancer amongst women worldwide. Environmental factors such as smoking and obesity, and recurrent infection by high-risk human papillomavirus subtypes are known to promote progression towards invasive cervical disease. Infection by high-risk HPV is necessary in most cases but not sufficient to develop invasive cervical cancer. Despite a predicted genetic heritability of between 27-36%, known genetic susceptibility loci that may be tumorigenic or influence host response to infection, only account for a small fraction of heritable risk factors so far. Various biobank-driven population based studies and meta-analyses have found corroborative evidence for several risk variants at the 6p21.3 locus (HLA), while many reports of variants outside the HLA region remain to be validated in other cohorts. Here, we review cervical cancer susceptibility variants arising from recent genome-wide association studies and meta-analysis in large cohorts and propose 2q14 (PAX8), 17q12 (GSDMB), and 5p15.33 (CLPTM1L) as consistently replicated non-HLA cervical cancer susceptibility loci. We further discuss the available evidence for these loci, knowledge gaps, future perspectives, and the potential impact of these findings on precision medicine strategies to combat cervical cancer.

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The significance of tissue cell changes preceding uterine cervix carcinoma

Nieburgs

1963

Cancer

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Carcinoma-in-situ and Dysplasia of the Cervix*

Cited by 6 publications

References 0 publications

Genomic Risk Factors for Cervical Cancer

Genomic Risk Factors for Cervical Cancer

Genomic Risk Factors for Cervical Cancer

The significance of tissue cell changes preceding uterine cervix carcinoma

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