Carcinoma in-situ of the Oral Mucosa has a Definite Tendency towards Keratinization.

Syafriadi, Mei; Ida-Yanemochi, Hiroko; Ikarashi, Terué; Maruyama, Satoshi; Jen, Kai Yu; Cheng, Jun; Hoshina, Hideyuki; Takagi, Ritsuo; Saku, Takashi

doi:10.3353/omp.8.43

Cited by 6 publications

(10 citation statements)

References 3 publications

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“…Such a well‐differentiated tendency is widely considered to be characteristic of oral SCC. Then why is this not the case for oral CIS? 12 Almost half of the surgical margins with CIS ranging from the basaloid to acanthotic types, were shown to develop into SCC. These retrospective data indicates that there were definite numbers of such well‐differentiated types in oral CIS, in addition to authentic basaloid CIS 5 .…”

Section: Discussionmentioning

confidence: 99%

“…This is because it is not easy to follow individual cases of dysplasia until they develop into frankly invasive carcinomas and also because some cases of dysplasia have been known to be self‐regressive 8 . We have noted the characteristic two‐phase appearance of epithelial dysplasia, which is frequently found in the periphery of invasive carcinoma or CIS and reasonably considered to be related to malignancy 9–13 . Based on topography we have also proposed that oral CIS has a definite tendency towards keratinization, because non‐invasive but obviously atypical epithelial lesions in the vicinity of invasive carcinoma foci tend to be keratinized 12 .…”

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confidence: 96%

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Histopathological varieties of oral carcinomain situ: Diagnosis aided by immunohistochemistry dealing with the second basal cell layer as the proliferating center of oral mucosal epithelia

Kobayashi

Maruyama

Cheng³

et al. 2010

Pathology International

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105

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To make reproducible diagnoses for oral carcinoma in situ (CIS), combined immunohistochemistry directed at the positioning of squamous cell proliferation (Ki-67) and differentiation (keratin (K) 13 and K19) was used, both of which support histological evaluations by providing biological evidence. Normal/hyperplastic epithelia was defined by K19+ cells only in the first basal layer, K13+ cells in the third basal and upper layers, and sporadic Ki-67+ cells in the second basal layer. These profiles indicated that a proliferating center of the oral epithelium is located in the parabasal cell layer, and K19 and K13 can be regarded as markers for basal and prickle cells, respectively. Epithelial dysplasia was characterized by irregular stratification of Ki-67+ cells and the absence of K19/K13 in proliferating cells. Irregular emerging of K19+ and K13+ cells in proliferating foci with unique stratification of atypical Ki-67+ cells indicated CIS. When the definition was applied, surgical margins in 172 recurrent cases were shown to contain CIS (39.4%) and squamous cell carcinoma (55.8%), indicating that the new diagnostic criteria for CIS reflected clinical behaviors of the cases. The results indicate that oral CIS contain more histological variations, especially those with definite keratinization, than what had been previously defined.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 96%

Histopathological varieties of oral carcinomain situ: Diagnosis aided by immunohistochemistry dealing with the second basal cell layer as the proliferating center of oral mucosal epithelia

Kobayashi

Maruyama

Cheng³

et al. 2010

Pathology International

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105

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“…From our observation in this study that this particular form of epithelial dysplasia is frequently observed in the vicinity of severe dysplasia/carcinoma in situ , it is suggested that the basaloid cells proliferate focally in the lower layer of the epithelium and then replace the whole layer to become severe dysplasia/carcinoma in situ . After that, they may be differentiated again toward keratinization (38). In this step, apoptotic figures are expected to decrease in number from the middle layer, and instead apoptosis may be induced by a crowding condition in the lower layer of severe dysplasia/carcinoma in situ , which was observed in the present study as well as in the previous studies (5, 9).…”

Section: Discussionmentioning

confidence: 99%

Two‐phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells

Syafriadi

Cheng

Jen

et al. 2005

J Oral Pathology Medicine

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“…The morphological differentiation of keratinizing well-matured and differentiated cancer tissue and normal mucosa is very difficult. Although CIS (WHO) in the oral mucosa is an accepted concept, there are very few reported cases, and almost all of these show keratinizing matured and differentiated histopathological features [10,11,42,45,[84][85][86]. As mentioned above, the most common and distinct histological variations are recognized as differentiated and basaloid types, with transitional variations between them in many cases.…”

Section: Pathological Findings Of Oin/cis (Jsop)mentioning

confidence: 97%

Oral premalignant lesions: from the pathological viewpoint

Izumo

2011

Int J Clin Oncol

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Under the widely used World Health Organization (WHO) classification for the pathological diagnosis of oral premalignant lesions, dysplasia, which is graded as mild, moderate or severe, and carcinoma in situ (CIS), which is a non-invasive carcinoma, are classified as precursor lesions of oral squamous cell carcinoma. Since the first edition (Wahi et al. International histological classification of tumours no. 4, WHO, Geneva, 1971), the criterion for CIS--that all epithelial layers are replaced by atypical cells--has remained unchanged. However, this dysplasia-carcinoma sequence theory was introduced from the viewpoint of pathological changes in the uterine cervix: in contrast, almost all premalignant lesions and CIS of the oral mucosa show superficial maturation and differentiation. Based on this recognition, the squamous intraepithelial neoplasia (SIN) classification and Ljubljana classification were included in WHO's latest edition published in 2005. Although the WHO classification is commonly used in Japan, recent developments in oral oncology have promoted modifications of the classification used in this country. In 2005, the Working Group of the Japan Society for Oral Tumours advocated iodine staining and proposed a modified SIN system, and in 2007, the Working Committee of the Japanese Society for Oral Pathology (JSOP) reported a new CIS (JSOP) definition that included differentiated-type CIS. In 2010, based on these studies, a new entity--oral intraepithelial neoplasia (OIN)--was included in the first edition of General Rules for Clinical and Pathological Studies on Oral Cancer. In this review, we focus on the OIN/CIS (JSOP) new classification of premalignant lesions in oral mucosa, which further advances the concept of SIN.

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Carcinoma in-situ of the Oral Mucosa has a Definite Tendency towards Keratinization.

Abstract: and Saku T. Carcinoma in-situ of the oral mucosa has a definite tendency towards keratinization.

Cited by 6 publications

References 3 publications

Histopathological varieties of oral carcinomain situ: Diagnosis aided by immunohistochemistry dealing with the second basal cell layer as the proliferating center of oral mucosal epithelia

Histopathological varieties of oral carcinomain situ: Diagnosis aided by immunohistochemistry dealing with the second basal cell layer as the proliferating center of oral mucosal epithelia

Two‐phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells

Oral premalignant lesions: from the pathological viewpoint

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