Carcinoma of gallbladder: Clinical evaluation and survival rate at a tertiary care center in Rajasthan

Goyal, Gopal; Narayan, Kumar Shwetanshu; Gupta, Gaurav; Nijhawan, Sandeep

doi:10.1007/s12664-017-0766-0

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…The early stage of the disease is very similar to the symptoms of cholecystitis, so early diagnosis is more difficult (4). This has seriously affected the quality of life of patients and caused a great economic and spiritual burden on the patient’s families (5).…”

Section: Introductionmentioning

confidence: 99%

The Effect and Mechanism of Vascular Endothelial Growth Fac-tor (VEGF) on Tumor Angiogenesis in Gallbladder Carcinoma

Xu¹,

Li²,

Jiang³

et al. 2019

ijph

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Background: To investigate the effect of vascular endothelial growth factor (VEGF) on tumor angiogenesis in gallbladder carcinoma. Methods: Fifty one patients with gallbladder carcinoma were enrolled as observation group. Thirty healthy people were included as control group. Chemically synthesized siRNA sequences targeting VEGF was transfected with VEGF-siRNA. A blank group (group B), a negative control group (transfected with independent sequence, group C), and an inhibition group (transfected with VEGF siRNA, group D) were established. Physiological saline was set as group A. The expression of VEGF was detected by qRT-PCR. The expression of VEGF protein was detected by Western blot. MVD was used to measure microvessel density. CCK-8, Transwell and flow cytometry were used to detect cell proliferation, invasion and apoptosis. Results: The tumor volume of nude mice and VEGF mRNA expression in group D was significantly smaller than that in group B and C (P<0.05). The MVD density in group B and C was significantly higher than that in group D (P<0.01). The proliferation of cells was detected from the 3rd day, and the proliferation of cells in the blank and negative control groups was faster than that of the inhibition group (P<0.05). The apoptosis rate of the blank group and the negative control group was lower than that of the inhibition group (P<0.001). Conclusion: VEGF is highly expressed in serum of patients with cholangiocarcinoma, it promotes angiogenesis, proliferation and invasion of gallbladder cancer cells, and inhibits apoptosis of tumor cells.

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Section: Introductionmentioning

confidence: 99%

The Effect and Mechanism of Vascular Endothelial Growth Fac-tor (VEGF) on Tumor Angiogenesis in Gallbladder Carcinoma

Xu¹,

Li²,

Jiang³

et al. 2019

ijph

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“…7 A study from Rajasthan reported 52.1% incidence of gall stones. 11 In contrast a study from southern India has shown that only 19% of gall bladder cancer patients have associated gall stones. 12 Gall bladder cancer usually present with very nonspecific symptoms.…”

Section: Discussionmentioning

confidence: 95%

“…Goyal et al has shown survival rate for stage II, stage IIIa, stage IIIb, stage IVa and stage IVb was >12, 10, 8.75, 4.5 and 1.5 months respectively. 11 In a retrospective analysis of 99 gall bladder cases; Pandey et al has shown similar stage wise survival. On analysis of survival pattern based on intervention, median survival time in groups undergoing extended cholecystectomy, noncurative surgery, chemotherapy alone was 12, 8 and 4 months respectively.…”

Section: Survival Functionsmentioning

confidence: 89%

Carcinoma of the gall bladder: 8 year experience from a tertiary care centre, Punjab, India

Sharma¹,

Singh²

2019

Int Surg J

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Background: Gall bladder carcinoma is the most common malignancy of biliary tract and one of the most aggressive gastrointestinal malignancies. The present study was conducted to know the clinical aspects, results and survival patterns after therapeutic interventions in patients of gall bladder cancer.Methods: The study is retrospective analysis of prospectively collected data of gall bladder cancer patients.Results: In 288 gall bladder cancer patient’s median age was 60 yrs. There were 219 females, 69 males (F:M=3.2:1). Median number of days from the onset of symptoms to presentation was 24.5 days. Majority of patients were stage IVB 162 (56.3%), least were stage I 3(1%). 192 (66.7%) patients received palliative treatment because of unresectable malignancy. 39 (13.5%) patients underwent noncurative surgical intervention. 57 (19.8%) patients underwent extended cholecystectomy. The median number of lymph nodes detected on histopathological examination was 4.5 (range 3-12). 21 patients (36.8%) had positive lymph nodes. Median follow up of all patients was 6 months (1-66 months). 27 (9.4%) patients survived till last date of follow up. Median survival time in groups undergoing extended cholecystectomy, noncurative surgery, chemotherapy alone was 12, 8 and 4 months respectively. The difference in median survival time between the groups was statistically significant, Log rank (Mantel-Cox) χ2=109.78, p=0.00.Conclusions: Carcinoma of the gall bladder predominately affects females. Majority of patients had delayed presentation, stage IVB. Extended cholecystectomy is the only effective treatment to achieve long term survival.

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“…While abdominal pain is a common symptom, patients may also experience general symptoms like malaise, weight loss, and low-grade fever. In severe cases, complications such as umbilical discharge due to peritoneal seeding, gallbladder perforation leading to bilioma formation, obstructive jaundice, abscess formation, and sinus formation in the anterior abdominal wall may occur (15). Unusual ndings associated with GB TB include bilateral adrenal enlargement or a cystic mass in the gallbladder.…”

Section: Discussionmentioning

confidence: 99%

Challenges in Diagnosing Gallbladder Tuberculosis Mimicking Acute Calculus Cholecystitis: A Case Report of an Uncommon Presentation

Munira,

Hasan,

Jalil

et al. 2024

Preprint

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Introduction : Gall bladder tuberculosis (TB) represents a highly uncommon form of extra-pulmonary TB, even within endemic regions, presenting a considerable diagnostic challenge. Limited pre-operative diagnostic tools lead to cholecystectomy and tissue analysis to initiate definitive treatment, thereby prolonging patient suffering and delaying diagnosis. Case Presentation : A 50-year-old menopausal lady presented with history of prolonged fever, significant weight loss, and subsequent upper abdominal pain. Serological and blood biochemistry tests revealed normal findings, except for moderate anemia. Abdominal ultrasound detected cystitis, while MRCP revealed a distal common bile duct stricture concomitant with gallstones. However, ERCP failed to confirm the biliary stricture, instead revealing papillary stenosis. The initial diagnosis was cholelithiasis, leading to laparoscopic cholecystectomy. The histopathological examination of the specimen indicated the presence of granulomas consisting of epithelioid cells and multinucleated giant cells. Additionally, areas of necrosis and chronic inflammatory cell infiltration were observed within the gallbladder wall. Histopathology of Lymph node biopsy showed granulomas, multinucleated giant cells, and areas of necrosis confirmed the diagnosis as gallbladder Tuberculosis. Category-1 Anti-Tubercular Therapy was initiated postoperatively, resulting in favorable clinical and operative outcomes. Conclusion Although gall bladder TB is a rare entity, clinicians should raise a high index of suspicion for TB in patients presenting with prolonged fever, weight loss, and features suggestive of calculus cholecystitis in endemic areas, aiming to mitigate unnecessary investigations and treatments, particularly in resource-limited settings such as Bangladesh.

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Carcinoma of gallbladder: Clinical evaluation and survival rate at a tertiary care center in Rajasthan

Cited by 4 publications

References 3 publications

The Effect and Mechanism of Vascular Endothelial Growth Fac-tor (VEGF) on Tumor Angiogenesis in Gallbladder Carcinoma

The Effect and Mechanism of Vascular Endothelial Growth Fac-tor (VEGF) on Tumor Angiogenesis in Gallbladder Carcinoma

Carcinoma of the gall bladder: 8 year experience from a tertiary care centre, Punjab, India

Challenges in Diagnosing Gallbladder Tuberculosis Mimicking Acute Calculus Cholecystitis: A Case Report of an Uncommon Presentation

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