Carcinoma of Male Breast: A Rare Case Report From North East India With Review of Literature

Hazarika, Devid; Barua, Partha Pratim; Barman, Bhupen

doi:10.32677/ijcr.2019.v05.i03.007

Cited by 1 publication

(7 citation statements)

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“…Breast cancer predisposing genes, which are well-known for increasing the risk of breast cancer in women, also increase the risk of MBC. In this regard, the significance of the BRCA 2 gene mutation is much higher than that of its counterpart BRCA 1 in causing male breast cancer [4,8,9]. Other genes associated with MBC with proven penetrance are CHEK2, PALB2, TP53, PIK3CA, and RAD51 [10,11].…”

Section: Etiopathogenesis and Risk Factorsmentioning

confidence: 99%

“…Infiltrating ductal carcinomas (IDC) account for more than 90% of cases of malignant lesions in male breasts [4]. Other less common varieties include lobular, papillary, secretory, and mucinous lesions (8-10%).…”

Section: Histopathological Classificationmentioning

confidence: 99%

“…Earlier diagnosis could make a life-saving difference, as MBC is most often diagnosed in an advanced stage. Males presenting with suspected breast lesions should undergo a thorough clinical examination of both breasts and bilateral axilla, followed by using relevant imaging modalities such as ultrasonography, mammography, and magnetic resonance imaging (MRI), whenever needed [4]. Mammography is abnormal in nearly 90% of MBC and easily differentiates it from gynecomastia, the most common yet benign breast lesion in men [4].…”

Section: Diagnostic Workupmentioning

confidence: 99%

“…Males presenting with suspected breast lesions should undergo a thorough clinical examination of both breasts and bilateral axilla, followed by using relevant imaging modalities such as ultrasonography, mammography, and magnetic resonance imaging (MRI), whenever needed [4]. Mammography is abnormal in nearly 90% of MBC and easily differentiates it from gynecomastia, the most common yet benign breast lesion in men [4]. Any lesion suggestive of malignant pathology should be confirmed by tru-cut biopsy; a biopsy is always preferable as the immunohistochemistry (IHC) assay leading to simultaneous hormone receptor status evaluation.…”

Section: Diagnostic Workupmentioning

confidence: 99%

“…1 [2]). Literature suggests that MBC has a poor prognosis in comparison to female breast cancer [3,4]. The paucity of breast tissue in males contributes to surgically poor adequate margins.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of male breast carcinoma (MBC), although rare, recently has an increasing trend. The increase in incidence is associated with increasing age, and poor clinical outcome seen with MBC is mostly because of illiteracy and lack of health education and shyness in reporting to the clinical physician. In this context, a comprehensive review regarding this forth bursting clinical scenario is important. The present article focus on that aspect encompassing but not limited to different clinical studies. The randomized trials on MBC are sparse and most of the studies are retrospective in nature due to rarity of cases. MBC treatment line is derived from female breast cancer guidelines. MBC has a poorer prognosis than female breast cancer. MBC patients in India present in advanced stage and surgery remains challenging due to paucity of breast tissue. Post mastectomy radiation is indicated on the same lines as of female breast cancer and it decreases locoregional recurrence. Adjuvant hormonal therapy decreases recurrence and improves survival. Further clinical trials are required including large number of patients to study different parameters in respect of prognosis and survival.

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