Carcinoma of male urethra: Management of locally advanced disease with combined chemotherapy, radiotherapy, and penile-preserving surgery

Baskin, Laurence S.; Turzan, Charles

doi:10.1016/0090-4295(92)90035-u

Cited by 34 publications

(16 citation statements)

References 19 publications

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“…The reported radiotherapy results have thus been disappointing [27]. However, there may be a role for radiotherapy in male urethral carcinoma in combination with chemotherapy for downstaging of locally advanced lesions before surgical resection [35]. The role of lymphadenectomy in patients with suspected lymph node disease is undisputed.…”

Section: Discussionmentioning

confidence: 99%

The Treatment of Primary Urethral Carcinoma – the Dilemmas of a Rare Condition: Experience with Partial Urethrectomy and Adjuvant Chemotherapy

et al. 2001

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Background: Primary urethral carcinoma is a very rare condition, and no large-scale experience with such cases has been published. Treatment will therefore have to follow rules established for the treatment of similar conditions. Patients: Six cases of primary urethral carcinoma (5 male, 1 female) who had been treated at our institution between 1995 and 1999 were retrospectively analyzed. In 3 male cases, a primary urothelial carcinoma of the distal urethra was treated by distal urethrectomy only. In 3 other cases with locally advanced tumors and/or lymph node metastases surgical treatment was followed by adjuvant cisplatinum-containing chemotherapy. Results: In the 3 cases with distal urethral carcinoma, partial urethrectomy with preservation of the penis resulted in cure, with a follow-up of 12–71 months. In the cases with advanced disease, adjuvant chemotherapy after surgery has resulted in complete remissions in all 3 cases, with a follow-up of 4–47 months at present. Conclusions: In localized, noninvasive carcinoma of the distal male urethra, partial urethrectomy seems adequate and the avoidance of penile amputation justified. In advanced cases, after local excision and lymphadenectomy adjuvant chemotherapy which by necessity must follow the guidelines established for the treatment of other urothelial or squamous cell malignancies seems to be beneficial.

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Section: Discussionmentioning

confidence: 99%

The Treatment of Primary Urethral Carcinoma – the Dilemmas of a Rare Condition: Experience with Partial Urethrectomy and Adjuvant Chemotherapy

et al. 2001

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“…He found the survival rate of patients with low stages as 89% and high stages as 42% [12][13][14][15][16][17]. The most effective therapeutic modality for stage 3 and 4 patients was described as neoadjuvant chemotherapy or radiotherapy with or without surgery.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the male bulbomembranous (proximal) urethra—How should the treatment be done? A case report and review of the literature

Ayyıldız¹,

Karagüzel²,

Hurі³

et al. 2007

Int Urol Nephrol

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“…La chimiothérapie a pu donner de bons résultats dans les stades avancés, en complément d'un traitement chirurgical mutilant afin d'obtenir le contrôle local de la maladie 18 . Cependant, l'espoir actuel chez les malades porteurs d'un carcinome épidermoïde de l'urètre réside dans des protocoles thérapeutiques combinant radiothérapie et chimiothé-rapie en se basant sur les résultats obtenus dans les cancers épidermoïdes de l'oesophage et de l'anus 19 , ce qui permettrait une chirurgie moins mutilante.…”

Section: Discussionunclassified

Carcinome épidermoïde de l’urètre masculin révélé par une rupture spontanée de l’urètre

Ghorbel

Hafsia

Derouiche

et al. 2013

CUAJ

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Le carcinome épidermoïde de l’urètre masculin est une tumeurrare, les tumeurs de l’urètre tous types confondus représentantmoins de 1 % des tumeurs de l’appareil urinaire. Le pronosticreste défavorable malgré un traitement chirurgical énergique. Laradiochimiothérapie semble être un traitement prometteur, maisson rôle doit être défini par d’autres études.Nous rapportons un cas rare de carcinome épidermoïde del’urètre bulbo-membraneux découvert à un stade localement avancéaprès observation d’une rupture urétrale transtumorale chez unhomme âgé de 70 ans. Le patient a été traité, après drainage vésical,par une irradiation externe associée à une chimiothérapie parcisplatine, et est décédé après progression de la maladie sur un an.La rupture spontanée de l’urètre transtumorale est un modede découverte exceptionnel témoignant d’une évolution localedéfavorable, ce qui rend ces tumeurs difficilement opérables.Cependant, l’espoir actuel réside dans des protocoles thérapeutiquesassociant radiothérapie et chimiothérapie.

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Carcinoma of male urethra: Management of locally advanced disease with combined chemotherapy, radiotherapy, and penile-preserving surgery

Cited by 34 publications

References 19 publications

The Treatment of Primary Urethral Carcinoma – the Dilemmas of a Rare Condition: Experience with Partial Urethrectomy and Adjuvant Chemotherapy

The Treatment of Primary Urethral Carcinoma – the Dilemmas of a Rare Condition: Experience with Partial Urethrectomy and Adjuvant Chemotherapy

Squamous cell carcinoma of the male bulbomembranous (proximal) urethra—How should the treatment be done? A case report and review of the literature

Carcinome épidermoïde de l’urètre masculin révélé par une rupture spontanée de l’urètre

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