Carcinoma of Rectum and Low Sigmoid

Vandertoll, Donald J.; Beahrs, Oliver H.

doi:10.1001/archsurg.1965.01320110129021

Cited by 67 publications

(3 citation statements)

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“…Potential Risks EGD within 3 weeks of esophageal, gastric, or duodenal surgery, and sigmoidoscopy or colonoscopy within 3 weeks of colonic surgery might promote suture breakdown and wound dehiscence, bleeding, or perforation because of abrasion and stretch at sites of gastrointes tinal anastomoses or repair from endoscope intubation, torque, and insufflation [97][98][99]. In experimental animals, the bursting GI Endoscopy in High-Risk Patients Dig Dis 1996;14:228-244 strength of large or small intestinal anasto moses 7 days postoperatively was greater than 225 mm Hg.…”

Section: R Ecent G a S Tro In Te S Tin A L S U Rg E Rymentioning

confidence: 99%

Gastrointestinal Endoscopy in High-Risk Patients

Cappell¹

1996

Dig Dis

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In America more than 100,000 high-risk patients/year have conditions normally evaluated by gastrointestinal endoscopy. This review analyzes the safety and efficacy of gastrointestinal endoscopy in high-risk patients. Endoscopy during pregnancy raises the unique issue of fetal safety. The safety of esophagogastroduodenoscopy (EGD) during pregnancy has been examined in a case-controlled study of 83 patients, a mailed survey of 73 patients, and case reports. The safety of sigmoidoscopy during pregnancy has been examined in a case-controlled study of 45 patients, a mailed survey of 26 patients, and case reports. These studies suggest that EGD and sigmoidoscopy are not contraindicated during pregnancy. For example, EGD should be performed for significant upper gastrointestinal bleeding. The safety of colonoscopy during pregnancy is inadequately analyzed. In a study of 34 EGDs performed within 3 weeks of myocardial infarction, no endoscopic complications occurred in 26 clinically stable patients with uncomplicated myocardial infarction. However, 3 major endoscopic complications occurred in 8 clinically unstable patients. In a study of 9 sigmoi-doscopies within 3 weeks of myocardial infarction, no sigmoidoscopic complications occurred in 7 clinically stable patients. Several studies have shown that EGD, sigmoidoscopy, or colonoscopy is safe in patients with advanced HIV infection. AIDS patients should generally be endoscoped with the same aggressiveness as other patients. However, endoscopy may be unwise in any terminal patient. No complication occurred in 60 patients undergoing EGD within 3 weeks of esophageal, gastric, or duodenal surgery. One minor complication occurred in 36 patients undergoing sigmoidoscopy within 3 weeks of colonic surgery. These results suggest that EGD or sigmoidoscopy is not contraindicated within 3 weeks of gastrointestinal surgery. No complications occurred in 53 chronic obstructive pulmonary disease patients undergoing EGD. EGD appears to be safe in chronic obstructive pulmonary disease patients without severe hypoxemia or acute bronchospasm. Emergency EGD can be performed in patients with severe hypoxemia after endotracheal intubation.

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Section: R Ecent G a S Tro In Te S Tin A L S U Rg E Rymentioning

confidence: 99%

Gastrointestinal Endoscopy in High-Risk Patients

Cappell¹

1996

Dig Dis

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“…Altogether, 11 primary tumor sites were identi ed as rectum (59.3%), sigmoid (13.9%), right hemicolon (7.6%), colon (6.3%), ileocecal (4.5%), descending colon (1.1%), hepatic exure colon (0.8%), ascending colon (2.4%), transverse colon (1.7%), junction of the rectum and sigmoid (0.6%), and left hemicolon (1.9%). Rectum and sigmoid were classi ed as the terminal tumor sites 17 , and determined with higher incidence rate compared to other tumor sites ( Figure 3 A&B).…”

Section: Characterization Of Tumor Primary Sitesmentioning

confidence: 99%

Novel Prognostic Role of Serum CA19-9 Identified in Colorectal Terminal Tumor Site and Tubular Adenocarcinoma

He¹,

Hu²,

Chen³

et al. 2020

Preprint

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It is still illusive that the origination and contribution of different primary tumor sites in Colorectal Cancer (CRC). A total 1039 consecutive CRC patient’s profiles were collected and investigated the prediction role of multiple biomarkers during survival period. The correlation and survival analysis were applied to explore the prognostic value of clinical traits (primary tumor sites, and tumor subtypes, the incidence rate) and multiple biomarkers. The sigmoid and rectum (73%) demonstrated the highest incidence rate among other primary tumor sites (27%). Tubular adenocarcinoma, mainly rise from the terminal bowel tumor sites, has significantly worse clinical outcome, lower 5-year survival rate and shorter overall survival time. Serum level of CA19-9 was significantly positive correlated with sigmoid and rectum originated-CRC (Cor =0.88, p=2.2e-16). Higher serum level of CA19-9 (>37 U/mL) was significantly associated with terminal tumor sites, tubular adenocarcinoma and tumor with non-infiltrating. It could be applied for the precise diagnosis of CRC and terminal bowel cancer, especially in the tubular adenocarcinoma. Therefore, terminal tumor sites (sigmoid and rectum) demonstrated potential prognostic value in early screening for CRC patients. CA19-9 could be a promising biomarker for the diagnosis of terminal colorectal cancer, especially for the Tubular adenocarcinomas originated from sigmoid and rectum, and improve the clinical outcome.

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“…Sigmoid and rectal cancers typically manifest early symptoms and collectively constitute nearly two-thirds of colon malignancies. 2 The sigmoid colon stands as a frequently afflicted site by colorectal cancer, offering prospects for curability when detected at an incipient stage and preventability through the identification and removal of precursor adenomas. Risk determinants for the development of colorectal cancer, including the sigmoid colon, encompass dietary patterns, genetic predisposition, and environmental influences.…”

Section: Introductionmentioning

confidence: 99%

Competitive Risk Analysis of Prognosis in Older Adults with Sigmoid Colon Adenocarcinoma: A Population-Based Study

Du,

Guo,

et al. 2024

Cancer Control

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Background The purpose of this study is to employ a competing risk model based on the Surveillance, Epidemiology, and End Results (SEER) database to identify prognostic factors for elderly individuals with sigmoid colon adenocarcinoma (SCA) and compare them with the classic Cox proportional hazards model. Methods We extracted data from elderly patients diagnosed with SCA registered in the SEER database between 2010 and 2015. Univariate analysis was conducted using cumulative incidence functions and Gray’s test, while multivariate analysis was performed using both the Fine-Gray and Cox proportional hazards models. Results Among the 10,712 eligible elderly patients diagnosed with SCA, 5595 individuals passed away: 2987 due to sigmoid colon adenocarcinoma and 2608 from other causes. The results of one-way Gray’s test showed that age, race, marital status, AJCC stage, differentiation grade, tumor size, surgical status, liver metastasis status, lung metastasis status, brain metastasis status, radiotherapy status, and chemotherapy status all affected the prognosis of SCA ( P < .05). Multivariate analysis showed that sex, age, race, marital status, and surgical status affected the prognosis of SCA ( P < .05). Multifactorial Fine-Gray analysis revealed that key factors influencing the prognosis of SCA patients include age, race, marital status, AJCC stage, grade classification, surgical status, tumor size, liver metastasis, lung metastasis, and chemotherapy status ( P < .05). Conclusion Data from the SEER database were used to more accurately estimate CIFs for sigmoid colon adenocarcinoma-specific mortality and prognostic factors using competing risk models.

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Carcinoma of Rectum and Low Sigmoid

Cited by 67 publications

References 0 publications

Gastrointestinal Endoscopy in High-Risk Patients

Gastrointestinal Endoscopy in High-Risk Patients

Novel Prognostic Role of Serum CA19-9 Identified in Colorectal Terminal Tumor Site and Tubular Adenocarcinoma

Competitive Risk Analysis of Prognosis in Older Adults with Sigmoid Colon Adenocarcinoma: A Population-Based Study

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