Carcinoma of the cervix and the use of hyperbaric oxygen with radiotherapy: a report of a randomised controlled trial

Hemodynamic signature of breast cancer under fractional mammographic compression using a dynamic diffuse optical tomography system

“…Finally, the investigation of step release hemodynamics was inconclusive. However, this remains an area of interest, as the tumor vasculature is functionally defective and it has been hypothesized that it is not capable of a vasodilatory response, unlike the vessels in normal tissues [28,29]. We were expecting a significantly higher reperfusion in normal areas vs. the tumor.…”

Oxygenation inhibits ovarian tumor growth by down-regulating STAT3 and cyclin-D1 expressions

“…15 There are also other studies that showed a tumor inhibitory or negligible effect with HBO treatment. 19,20 On the other hand, a few studies have shown a suppressive effect of HBO on tumor growth. 13,21,22 Recently, we have reported that solid tumor xenografts of ovarian cancer were severely hypoxic, with the partial pressure of oxygen (pO 2 ) about 2 mmHg.…”

Hypoxia-selective activation of 5-fluorodeoxyuridine prodrug possessing indolequinone structure: radiolytic reduction and cytotoxicity characteristics

“…[1][2][3][4][5] Hypoxic cells have been recognized to show resistance to ionizing radiation, the biological action of which involves acceleration of oxidation, thus leading to post-irradiation regrowth of tumor. 6 For the radiation therapy of hypoxic tumor cells, there have been various strategies including hyperbaric oxygen therapy, 7,8 hypoxic cell radiosensitizers, [9][10][11][12] and hypoxic cytotoxins. 13 A new strategy to overcome tumor hypoxia focuses on the combination of radiotherapy and chemotherapy into prodrugs that are activated to release antitumor agents by hypoxic irradiation.…”