Carcinoma of the external auditory canal and middle ear

Pfreundner, Leo; Schwager, K.; Willner, Jochen; Baier, Kurt; Bratengeier, Klaus; Brunner, F. X.; Flentje, Michael

doi:10.1016/s0360-3016(98)00531-8

Cited by 92 publications

(94 citation statements)

References 29 publications

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“…Interestingly most SCC of the external auditory canal arose many years after RT, with a range of 10-30 years and a mean of 21, which is similar to the results of Goh et al [15]. The prognosis for patients with nonradiation-induced SCC of the external auditory canal is excellent (5-year survival of 100%) when the tumor is limited to the canal and can be completely resected [16]. One patient in this series underwent successful surgical resection to remove a small tumor that was localized to the external auditory canal.…”

Section: Discussionsupporting

confidence: 84%

MRI of radiation-induced tumors of the head and neck in post-radiation nasopharyngeal carcinoma

et al. 2009

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The aim of this study was to document the sites and MRI features of radiation-induced tumors (RITs) in the head and neck following treatment for nasopharyngeal carcinoma (NPC). The MRI examinations and clinical records of 20 patients with 21 RITs were reviewed retrospectively. RITs developed 3-30 years after radiotherapy and included eleven squamous cell carcinomas, six sarcomas, two neuroendocrine carcinomas, one mucoepidermoid carcinoma and one meningioma. RITs arose in the maxillary region (9), oro/hypopharynx and oral cavity (5), external auditory canal (4), nasopharynx and sphenoid sinus (2) and brain (1). Radiation-induced carcinoma and sarcoma had MRI features that were useful to distinguish them from recurrent NPC. To improve early detection of RITs, the check areas on an MRI of a patient with previous NPC treated by radiation should always include the maxillary region, tongue, and external auditory canal/temporal bone.

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Section: Discussionsupporting

confidence: 84%

MRI of radiation-induced tumors of the head and neck in post-radiation nasopharyngeal carcinoma

et al. 2009

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“…The extant literature consists of numerous case series that have reported a wide range of survival data, reflecting differences in the underlying characteristics of cohorts drawn from various institutions. 1,6,[8][9][10][12][13][14][15]18,19,22,24,[30][31][32][33][34][35][36][37][38][39][40][41] Historical survival data can be most readily generalized to clinical practice if factors predictive of outcome can be identified. Several larger series have reported preliminary descriptions of factors influencing survival, based on univariate comparisons.…”

Section: Discussionmentioning

confidence: 99%

“…These numbers are reflections of the underlying characteristics of the patient cohort at each institution. [8][9][10][11][12][13][14][15][17][18][19]22,23,[30][31][32]34,35,[37][38][39][40][41][42] Attempting to improve understanding of prognostic factors, 5 groups have recently analyzed outcomes using univariate analyses. In 1997, Testa et al 20 Based on these outcomes data, we currently consider the minimum operation for the vast majority of malignant disease involving the external auditory canal/temporal bone to be a lateral temporal bone resection.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

et al. 2011

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Background. The purpose of this study was to identify factors predictive of outcome in patients undergoing temporal bone resection (TBR) for head and neck cancer.Methods. This was a retrospective study of 72 patients undergoing TBR. Factors associated with survival and recurrence were identified on multivariable regression. Results. Most tumors were epithelial (81%), commonly (69%) involving critical structures. Cervical metastases were uncommon (6%). Squamous cell carcinoma (SCC) of the external auditory canal carried a high rate of parotid invasion (25%) and parotid nodal metastases (43%).The 5-year rate of overall survival (OS) was 62%; disease-specific survival (DSS), 70%; recurrence-free survival (RFS), 46%. Factors independently associated with outcome on multivariable analysis were margin status and extratemporal spread of disease to the parotid, mandible, or regional nodes. Recurrence was common (72%) in cT3-4 tumors. Conclusions. Margin status and extratemporal disease spread are the strongest independent predictors of survival and recurrence. In SCC of the external auditory canal, high rates of parotid involvement support adjunctive parotidectomy. Risk of recurrence in T3-T4 tumors may support a role for adjuvant therapy.

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“…The complexity of the temporal bone anatomy, which includes major vessels, cranial nerves and intracranial structures, makes the surgical procedure for EAC carcinoma particularly challenging. However, early diagnosis and adequate management of earlystage EAC carcinoma can afford a good prognosis [Barrs, 2001;Pfreundner et al, 1999;Spector, 1991;Yin et al, 2006;Zhang et al, 1999]. Surgery is usually recommended for resectable EAC tumors, and complete resection is the best approach to improve the prognosis [Zhang et al, 2013].…”

Section: Introductionmentioning

confidence: 99%

Hearing Preservation after Lateral Temporal Bone Resection for Early-Stage External Auditory Canal Carcinoma

Morita

Nakamaru²,

Homma³

et al. 2014

Audiol Neurotol

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Objective: To evaluate postoperative hearing outcomes after lateral temporal bone resection (LTBR) with reconstruction of the external auditory canal (EAC) and conductive function for early-stage EAC carcinoma. Methods: We retrospectively examined patients diagnosed with early-stage EAC carcinoma treated with surgery alone between January 2006 and December 2012. Patients who had postoperative adjuvant chemotherapy and/or radiotherapy were excluded. Patients receiving LTBR in combination with tympanoplasty were divided into two groups based on the reconstruction of the EAC with and without (w/o) split-thickness skin grafts (STSGs). Audiological data included the preoperative hearing thresholds and the most recent postoperative hearing thresholds obtained at least 12 months after surgery. The hearing outcome was evaluated based on pure-tone audiograms using the Committee on Hearing and Equilibrium guidelines of the American Academy of Otolaryngology-Head and Neck Surgery for the evaluation of the results of treatment of conductive hearing loss. The postoperative quality of life (QOL) for patients was evaluated using the Glasgow Benefit Inventory (GBI). Results: All patients (n = 15) achieved disease-free survival without significant morbidity or mortality. When we compared the mean air-bone gaps after surgery, those in the STSG group (n = 8) were found to be significantly lower than those in the w/o STSG group (n = 7; p < 0.001). The success rate for postoperative hearing was 75.0% in the STSG group, which was significantly higher than that in the w/o STSG group (p = 0.014). All patients in the w/o STSG group showed stenosis and closure of the EAC at fewer than 10 months after surgery. In contrast, all patients in the STSG group showed preserved conformation of the new EAC for more than 12 months after surgery. When we compared the mean GBI score between the two groups of patients, the overall and general health scores in the STSG group were found to be significantly higher than those in the w/o STSG group (p = 0.021, p = 0.001). Conclusions: Reconstruction of the EAC using a rolled-up STSG technique in combination with tympanoplasty after LTBR is useful for hearing preservation and the observation of locoregional lesions after surgery, resulting in improved QOL for patients. i 2014 S. Karger AG, Basel

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Carcinoma of the external auditory canal and middle ear

Cited by 92 publications

References 29 publications

MRI of radiation-induced tumors of the head and neck in post-radiation nasopharyngeal carcinoma

MRI of radiation-induced tumors of the head and neck in post-radiation nasopharyngeal carcinoma

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

Hearing Preservation after Lateral Temporal Bone Resection for Early-Stage External Auditory Canal Carcinoma

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