Carcinoma of the lip and selected sites of head and neck skin. A clinical study of 896 patients

Petrovich, Zbigniew; Parker, Robert G.; Luxton, Gary; Kuisk, Hans; Jepson, Joanne H.

doi:10.1016/s0167-8140(87)80017-8

Cited by 89 publications

(33 citation statements)

References 12 publications

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“…Published cumulative 5 year recurrence rates for subgroups agree with our results. 23 Our findings confirm results of earlier studies: higher cure rates of BCCs compared with SCCs, 8,9,15,18,36 of previously untreated tumors compared with previously treated and recurrent ones, 8,9,15,23,[34][35][36] and of smaller malignancies or those with a lower T-class or stage. y Tumor thickness (half-value depth) and field size had a different influence on recurrences and ulcerations after treatment of BCCs compared with SCCs.…”

Section: Discussionsupporting

confidence: 88%

Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

Schulte¹,

Lippold²,

Auras³

et al. 2005

Journal of the American Academy of Dermatology

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Section: Discussionsupporting

confidence: 88%

Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

Schulte¹,

Lippold²,

Auras³

et al. 2005

Journal of the American Academy of Dermatology

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“…The overall cure rate after X-ray therapy was consistent with published results, which range from 90% to 98% (Nevrkla and Newton, 1974;Orton, 1978, Reymann, 1980Dubin and Kopf, 1983;Fitzpatrick et al, 1984;Brady et al, 1987;Petrovich et al, 1987;Ashby et al, 1989;Mazeron et al, 1989;Rowe et al, 1989;Lovett et al, 1990;Wilder et al, 1991;Silverman et al, 1992b). More relapses occurred with brachytherapy in our study (8.8% failure rate at 4 years) than published in the literature, in which failure rates are less than 5% (Daly et al, 1984;Pierquin et al, 1987;Mazeron et al, 1989;Crook et al, 1990 (Chahbazian and Brown, 1980;Goldsmith and Sherwin, 1983;Brady et al, 1987;Pierquin et al, 1987;Mazeron et al, 1989;Morrison et al, 1993;Fleming et al, 1995).…”

Section: Failure Ratesupporting

confidence: 91%

Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study

Avril

Aupérin²,

Margulis³

et al. 1997

Br J Cancer

297

175

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Summary Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment of primary BCC of the face measuring less than 4 cm. The primary end point was the failure rate (persistent or recurrent disease) after 4 years of follow-up. The secondary end point was the cosmetic results assessed by the patient, the dermatologist and three persons not involved in the trial. In the course of the trial, 347 patients were treated. Of the 174 patients in the surgery group, 71% had local anaesthesia and 91% frozen section examination. Of the 173 patients in the radiotherapy group, 55% were treated with interstitial brachytherapy, 33% with contactherapy and 12% with conventional radiotherapy. The 4-year actuarial failure rate (95% Cl) was 0.7% (0.1-3.9%) in the surgery group compared with 7.5% (4.2-13.1%) in the radiotherapy group (log-rank P= 0.003). The cosmetic results assessed by four of the five judges were significantly better after surgery than after radiotherapy. Eighty-seven per cent of the surgery-treated patients and 69% of the radiation-treated patients considered the cosmetic result as good (P < 0.01). Thus, in the treatment of BCC of the face of less than 4 cm in diameter, surgery should be preferred to radiotherapy.

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“…Electrosurgery, cryosurgery, and radiation therapy fail to provide a specimen for the histologic confirmation of complete eradication. 5 Tumors appearing on the auricular concha may have a delayed diagnosis. Often, initial lesions are misdiagnosed as eczematous lesions and the followup is difficult for relatives and professionals because of the partially hidden location.…”

Section: Discussionmentioning

confidence: 99%