Carcinoma of the nasopharynx treated by radiotherapy alone: Determinants of local and regional control

Sanguineti, Giuseppe; Geara, Fady; Garden, Adam S.; Tucker, Susan L.; Ang, K. Kian; Morrison, William H.; Peters, Lester J.

doi:10.1016/s0360-3016(97)00104-1

Cited by 261 publications

(136 citation statements)

References 52 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…Sanguineti et al (26) described the results of radiotherapy alone in a Western centre and although nothing was stated about the referral strategy, the gures for local control, locoregional control and survival as well as prognostic factors in multivariate analyses were similar to those at the same level as that in our material for stages III and IV, for both 3-and 5-year survival. Serin et al (32) used radiation therapy and concurrent cisplatin in a non-randomized series and were able to demonstrate reduced locoregional failure, and improved survival, but without reduced systemic failure.…”

Section: Discussionsupporting

confidence: 67%

Squamous Cell Carcinoma of the Nasopharynx&An Analysis of Treatment Results in 149 Consecuti v e Patients

Johansen

Grau²,

Overgaard³

2001

Acta Oncologica

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 67%

Squamous Cell Carcinoma of the Nasopharynx&An Analysis of Treatment Results in 149 Consecuti v e Patients

Johansen

Grau²,

Overgaard³

2001

Acta Oncologica

View full text Add to dashboard Cite

“…It is also confirmed that .IMRT can protect the funcution of salivary glands in clinical treatment (Pow et al, 2006;Kam et al, 2007). But the follow-up after IMRT treatment, we found that the retention rate of nasopharyngeal carcinoma with local recurrence rate is as high as 30% (Sanguineti et al, 1997). It most occurred in the GTV, which exists a group of tumor cells that are highly resistant to radiation .The study also confirms that the cancer stem cells of nasopharyngeal carcinoma existed in this group of cells, which is the root cause of the relapse .…”

Section: Introductionsupporting

confidence: 70%

Dosimetric Verification for Primary Focal Hypermetabolism of Nasopharyngeal Carcinoma Patients Treated with Dynamic Intensity-modulated Radiation Therapy

Xin

Wang²,

Li³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Objective: To make sure the feasibility with 18F FDG PET/CT to guided dynamic intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma patients, by dosimetric verification before treatment. Methods: Chose 11 patients in Ⅲ~ⅣA nasopharyngeal carcinoma treated with functional image-guided IMRT and absolute and relative dosimetric verification by Varian 23EX LA, ionization chamber, 2DICA of I'mRT Matrixx and IBA detachable phantom. Drawing outline and making treatment plan were by different imaging techniques (CT and 18F FDG PET/CT). The dose distributions of the various regional were realized by SMART. Results: The absolute mean errors of interest area were 2.39%±0.66 using 0.6cc ice chamber. Results using DTA method, the average relative dose measurements within our protocol (3%, 3 mm) were 87.64% at 300 MU/min in all filed. Conclusions: Dosimetric verification before IMRT is obligatory and necessary. Ionization chamber and 2DICA of I'mRT Matrixx was the effective dosimetric verification tool for primary focal hyper metabolism in functional image-guided dynamic IMRT for nasopharyngeal carcinoma. Our preliminary evidence indicates that functional image-guided dynamic IMRT is feasible.

show abstract

“…Currently, radiotherapy is the mainstay of treatment for NPC. However, a high proportion of NPC patients, particularly patients with advanced NPC, exhibit radioresistance and exhibit poor outcomes (4,5). Therefore, exploring the molecular mechanisms underlying sensitivity to radiation or resistance as well as the combination of chemoand radiotherapy is of crucial significance for NPC therapy.…”

Section: Introductionmentioning

confidence: 99%

MiR-593 mediates curcumin-induced radiosensitization of nasopharyngeal carcinoma cells via MDR1

et al. 2016

View full text Add to dashboard Cite

Abstract. Curcumin (Cur) exhibits radiosensitization effects to a variety of malignant tumors. The present study investigates the radiosensitizing effect of Cur on nasopharyngeal carcinoma (NPC) cells and whether its mechanism is associated with microRNA-593 (miR-593) and multidrug resistance gene 1 (MDR1). A clonogenic assay was performed to measure the radiosensitizing effect. The expression of miR-593 and MDR1 was analyzed by quantitative polymerase chain reaction (qPCR) or western blot assay. A transplanted tumor model was established to identify the radiosensitizing effect in vivo. A luciferase-based reporter was constructed to evaluate the effect of direct binding of miR-593 to the putative target site on the 3' UTR of MDR1. The clonogenic assay showed that Cur enhanced the radiosensitivity of cells. Cur (100 mg/kg) combined with 4 Gy irradiation inhibited the growth of a transplanted tumor model in vivo, resulting in the higher inhibition ratio compared with the radiotherapy-alone group. These results demonstrated that Cur had a radiosensitizing effect on NPC cells in vivo and in vitro; Cur-mediated upregulation of miR-593 resulted in reduced MDR1 expression, which may promote radiosensitivity of NPC cells.

show abstract

Carcinoma of the nasopharynx treated by radiotherapy alone: Determinants of local and regional control

Cited by 261 publications

References 52 publications

Squamous Cell Carcinoma of the Nasopharynx&An Analysis of Treatment Results in 149 Consecuti v e Patients

Squamous Cell Carcinoma of the Nasopharynx&An Analysis of Treatment Results in 149 Consecuti v e Patients

Dosimetric Verification for Primary Focal Hypermetabolism of Nasopharyngeal Carcinoma Patients Treated with Dynamic Intensity-modulated Radiation Therapy

MiR-593 mediates curcumin-induced radiosensitization of nasopharyngeal carcinoma cells via MDR1

Contact Info

Product

Resources

About