Carcinoma of the Oral Tongue: A Case Series Analysis of Prognostic Factors and Surgical Outcomes

Süslü, Nilda; Hoşal, Ali Şefik; Aslan, Tuğba; Sözeri, Bülent; Dolgun, Anıl

doi:10.1016/j.joms.2013.01.018

Cited by 40 publications

(41 citation statements)

References 20 publications

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“…The prognosis of tongue cancer generally depends on the stage of the original tumor and on metastasis to cervical lymph nodes, on the character of the tumor, and on the differentiation of tumor cells [1][2][3][4]17]. The 5-year survival rate was found to be significantly lower in patients with cancers on the back third than on the forward and central thirds of the tongue, indicating that patients with tumors arising in the back third of the tongue have a very poor prognosis [14].…”

Section: Resultsmentioning

confidence: 99%

“…Approximately 60% of tongue cancers show internal growth, similar to ulcer formation, with fewer showing external growth [1][2][3][4]. Most of these lesions occur on the lateral borders of the tongue, especially the region corresponding to the molars, with tumors on the tip of the tongue being rare [14].…”

Section: Discussionmentioning

confidence: 99%

“…Although treatment plans differ in our institution [1][2][3], early cancers (i.e. less than the T2 level) in our department are generally treated surgically, with 10-mm safety margins.…”

Section: Discussionmentioning

confidence: 99%

“…These tumors can also induce functional disorders of the stomatognathic system [1][2][3][4][5]. Many tumors occur on the lateral borders of the tongue, whereas their occurrence on the tip of the tongue is rare [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Pedunculated Squamous Cell Carcinoma on the Tip of the Tongue

Yamamoto¹,

Kawai²,

Ken³

2017

Oral Health Case Rep

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Although treatment plans differ in our institution [1][2][3], early cancers (i.e. less than the T2 level) in our department are generally treated surgically, with 10-mm safety margins.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pedunculated Squamous Cell Carcinoma on the Tip of the Tongue

Yamamoto¹,

Kawai²,

Ken³

2017

Oral Health Case Rep

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“…After tongue SCC resection, the presence of perineural invasion (PNI) and deep locoregional invasion metastasis, tumor positivity at the surgical margins, and close surgical margins are poor prognostic factors (11). Tongue cancers are tumors that frequently show recurrence within the first year.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Correlation Between Prognostic Factors and Long-Term Mortality in Tongue Cancers

Kubat¹,

Beton²,

Gerçeker³

2016

Istanbul Med J

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The incidence of head and neck cancer is increasing in many parts of the world. Oral cavity cancer comprises approximately 3% of all types of cancer, and tongue cancer is the most common type of oral cavity cancer (1). Because a reliable epidemiological study has not yet been conducted, it is not possible to give a clear description of this subject in our country. Although head and neck cancer is usually diagnosed in the sixth decade of the patient's life, the prevalence among young patients (younger than 40 years) is increasing (2). Tongue cancer is more common in men; however, due to an increase in tobacco use, some studies have reported that the incidence of tongue cancer has increased among women as well.90% of the etiological factors of tongue cancer are associated with cigarettes, cigars, pipes, tobacco use, passive smoking, and alcohol consumption. Human papilloma virus (HPV) is also an infectious agent whose carcinogenic effects have been well proven (3). Other etiological factors are suppression of the immune system due to human immunodeficiency virus (HIV), long-term trauma secondary to the long-term use of inappropriate dentures, and poor oral hygiene.Squamous cell carcinoma (SCC) represents over 90% of oral cavity and tongue cancer cases (4). Premalignant lesions are classified as leukoplakia, erythroplakia, oral submucosal fibrosis, and oral lichen planus; studies conducted on this subject state that 6.6%-36.4% of premalignant lesions progress to invasive carcinoma within 1.5-8.5 years. Compared to leukoplakia, erythroplakia has a higher risk of malignancy (5).The tumor stage, histopathologic stage, growth pattern, lymph nodes in the neck and distant metastasis, and classification of the tumor as secondary or primary are important factors in determining the prognosis and survival in neck cancer cases. In cases of squamous cell carcinoma of the tongue, lymph node metastasis in the neck is quite common, and patients clinically diagnosed with non-metastatic lymph nodes in the neck (N0) have a high rate of occult metastasis.After histopathological diagnosis, for staging, computed tomography (CT) and/or magnetic resonance imaging (MRI) should be performed. Positron emission tomography (PET) is used in the determination of distant metastases in advanced stage disease (6).The choice of treatment varies depending on the status of the primary tumor and locoregional lymph node involvement. Surgery and radiotherapy (RT) can be applied as primary treatments The Effect of Correlation Between Prognostic Factors and Long-Term Mortality in Tongue CancersObjective: The aim of this study was to review demographic data, prognostic factors, and the effect on mortality of patients who were treated for tongue cancer and followed up at our clinic.Methods: Data between 2000 and 2013 were retrospectively reviewed. This report includes data from 96 patients. Demographic data, dental prostheses, smoking and drinking habits, CVs, tumor characteristics, treatment methods, recurrence, distant metastasis, second primary tumor pre...

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SOX9 promotes stemness in the CAL27 cell line of tongue squamous cell carcinoma

Sheng,

Fu,

Zhou

et al. 2024

Cell Biochemistry & Function

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Tongue squamous cell carcinoma (TSCC) is a prevalent form of oral malignancy, with increasing incidence. Unfortunately, the 5‐year survival rate for patients has not exceeded 50%. Studies have shown that sex‐determining region Y box 9 (SOX9) correlates with malignancy and tumor stemness in a variety of tumors. To investigate the role of SOX9 in TSCC stemness, we analyzed its influence on various aspects of tumor biology, including cell proliferation, migration, invasion, sphere and clone formation, and drug resistance in TSCC. Our data suggest a close association between SOX9 expression and both the stemness phenotype and drug resistance in TSCC. Immunohistochemical experiments revealed a progressive increase of SOX9 expression in normal oral mucosa, paracancerous tissues, and tongue squamous carcinoma tissues. Furthermore, the expression of SOX9 was closely linked to the TNM stage, but not to lymph node metastasis or tumor diameter. SOX9 is a crucial gene in TSCC responsible for promoting the stemness function of cancer stem cells. Developing drugs that target SOX9 is extremely important in clinical settings.

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Carcinoma of the Oral Tongue: A Case Series Analysis of Prognostic Factors and Surgical Outcomes

Cited by 40 publications

References 20 publications

Pedunculated Squamous Cell Carcinoma on the Tip of the Tongue

Pedunculated Squamous Cell Carcinoma on the Tip of the Tongue

The Effect of Correlation Between Prognostic Factors and Long-Term Mortality in Tongue Cancers

SOX9 promotes stemness in the CAL27 cell line of tongue squamous cell carcinoma

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