Carcinoma of the Penis

Abstract

This study updates the experience at our hospital with cancer of the penis, which now includes 122 consecutive cases seen between 1940 and 1974 with 100 per cent followup. Historical, clinical, pathological, therapeutic and followup data were extracted for all cases in a digital code for transfer to computer storage. Life tables giving cumulative survival rates through 10 years with standard deviations and age corrections were calculated for each variable. The data were tabulated for publication to emphasize the prognostic significance of individual variables for the purpose of prospective research planning. The data were then evaluated regarding indications for prophylactic inguinal lymph node dissections, if any.

Corpus Cavernosum Invasion and Tumor Grade in the Prediction of Lymph Node Condition in Penile Carcinoma

“…Ekström and Edsmyr [15] found positive nodes in 24% of G I, in 37% of GII and in 33% of G III patients. Fraley et al [7] noticed that 4% of patients with GI developed nodal métastasés, and in 88.6% of patients with GII-III, Baker et al [11] and Kherzi et al [29] related tumor grade and survival.…”

Surgical Treatment of Invasive Penile Cancer - The Heidelberg Experience from 1968 to 1994

“…Baker et al [14] [15] saw a significant survival advan tage for all tumor stages after immediate ilioinguinal lymphadenectomy. There are only a few data on radiation therapy of groin nodes.…”

“…The discussion is focused on how radical the therapeutic intervention should be for the local control of the primary tumor and the management of clinically negative inguinal lymph nodes [8][9][10], The time point and the extent of the inguinal lymph node dissection are further unsolved ques tions with respect to penile cancer. Clinical access to mod em therapeutic modalities such as laser coagulation and modern radiotherapy has prompted several authors (mostly radiotherapists) to advocate penis-conserving treatment options for organ-confined penile carcinomas [5,6,11,12], The high rate of local recurrence of 22-50% [1,6,13] even for tumors confined to the glans (T1 ) is not regarded as an oncologic contradiction since recurrences were only expected locally [6,7,14] and should be man aged by operative salvage procedures. Nevertheless, most surgeons prefer partial amputation [1,9,10], In our series, 56% of patients with conservatively treated stage T1 penile carcinomas experienced a local recurrence, in half of the cases with simultaneous inguinal lymph node mé tastasés.…”

Verrucous Carcinoma of the Penis: Importance of Human Papillomavirus Typing for Diagnosis and Therapeutic Decision

“…The tumor is now mostly well differentiated, however, focal areas of invasive less differen tiated squamous carcinoma with cellular anaplasia, higher mitotic activity and ruptures of the basal membrane are not rare and found in 25 % of cases [8], On a histological basis alone, a differential diag nosis with the classical squamous carcinoma remains very difficult. The differential diagnosis is capital since the prognoses of these two tumors are totally different [3,7,13], We point out, in particular, that the verrucous carcinoma, contrary to the classical epidermoid carci noma, only rarely produces métastasés. In addition to this observa tion, it is noteworthy that those cases with métastasés had received radiation therapy, which is absolutely contraindicated for the verru cous carcinoma [10,15,17], In recent years, advances in techniques of molecular biology have allowed to suggest the role of various HPV…”