Carcinoma of the pyriform sinus: a retrospective analysis of treatment results over a 20-year period

Elias, Michael; Hilgers, F. J. M.; Keus, Ronald B.; Gregor, R. T.; Hart, A.A.M.; Balm, Alfons J. M.

doi:10.1111/j.1365-2273.1995.tb01860.x

Cited by 47 publications

(42 citation statements)

References 31 publications

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“…Earlier reports using radiotherapy alone have not been as encouraging, with local recurrences ranging from 23% to 65%. 25,26 Nonetheless, the literature does clarify the need for combined-modality therapy with radiation therapy and surgery, usually a post-radiotherapy neck. 23 This has emerged as the standard of care for the treatment of these patients.…”

Section: Discussionmentioning

confidence: 97%

Resection of selected invasive squamous cell carcinoma of the pyriform sinus by means of the lateral pharyngotomy approach: The partial lateral pharyngectomy

et al. 2006

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Section: Discussionmentioning

confidence: 97%

Resection of selected invasive squamous cell carcinoma of the pyriform sinus by means of the lateral pharyngotomy approach: The partial lateral pharyngectomy

et al. 2006

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“…In the study of Hung et al [4], distant metastases also occurred in 24.0% of patients treated with CRCT. In the retrospective analysis of Elias et al [32] on treatment results of carcinoma of the pyriform sinus, 32.0% of patient population developed distant metastases. The frequency of DM of 46.7% as first site of failure in our study was ten fold higher compared to the results reported by Johansen et al [2].…”

Section: Discussionmentioning

confidence: 99%

Concurrent radiochemotherapy in advanced hypopharyngeal cancer

2010

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BackgroundConcurrent platinum-based radiochemotherapy has been recommended as a standard of care in patients with locally advanced squamous cell head and neck carcinomas. Unfortunately, there is a lack of level one evidence on best treatment approach for advanced hypopharyngeal cancer. This report aims to summarize the results of our study on concurrent radiochemotherapy in patients with advanced hypopharyngeal cancer.MethodsA retrospective analysis of 41 patients with stage III-IV hypopharyngeal cancer was performed. All patients were treated with three dimensional conformal radiotherapy and received 70 Gy in 35 fractions (2 Gy per fraction, 5 fractions per week). In dependence of the period when radiotherapy was realized, two different treatment techniques were used. Concurrent chemotherapy consisted of cisplatin 30 mg/m2 given on a weekly basis.ResultsThe median age was 52 years (range 29-70). Stage IV disease was recognized in 73.2% of the patients. Complete response rates at the primary site and at the metastatic neck lymph nodes were 68.3% and 36.6%, respectively. A complete composite response was present in 27 patients (65.9%). Median follow-up was 13 months (range 7-36). Distant metastases as initial failure occurred in 7 patients (46.7%). The 2-year local relapse-free survival and regional relapse-free survival rates were 55.2% and 75.8%, respectively. The 2-year locoregional relapse-free survival rate was 51.3%. The 2-year disease-free survival and overall survival rates were 29.3% and 32.8%, respectively. Confluent mucositis was developed in 46.3% of patients. Leucopenia grade 1 was the most frequent hematological toxicity. The median weight loss at the end of treatment was 12% (range 5-21). The worst grade of late toxicity was most commonly pronounced in the skin and in the subcutaneous tissue.ConclusionsBased on unsatisfactory results in our study we suggest that the use of sequential radiochemotherapy or chemotherapy given concomitantly with altered fractionation radiotherapy with the implementation of intensity-modulated radiotherapy as radiotherapy technique could represent treatment approaches able to improve outcome in patients with advanced hypopharyngeal cancer.

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“…Hypopharyngeal cancers are often presented at an advanced stage at diagnosis and are therefore associated with a poor prognosis [1]. Tumors in the hypopharynx are often thought to pursue a particularly aggressive course.…”

Section: Introductionmentioning

confidence: 99%

Treatment results and prognostic factors in locally advanced hypopharyngeal cancer

Lee

Hsiao

et al. 2008

Acta Oto-Laryngologica

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There was no significant difference in T and N status between the two treatment groups, nor were there significant differences in overall or disease-free survival or the incidence of distant metastasis (p >0.05). In the CCRT group and SRT group, the estimated 3-year overall survival was 39% and 44%, respectively. The SRT group had better local control than the CCRT group (p <0.05). Relatively, 27% patients retained their larynx function for more than 2 years in the CCRT group. Radiation doses >70 Gy yielded significantly better survival and local control than doses <70 Gy (p <0.05).

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Carcinoma of the pyriform sinus: a retrospective analysis of treatment results over a 20-year period

Cited by 47 publications

References 31 publications

Resection of selected invasive squamous cell carcinoma of the pyriform sinus by means of the lateral pharyngotomy approach: The partial lateral pharyngectomy

Resection of selected invasive squamous cell carcinoma of the pyriform sinus by means of the lateral pharyngotomy approach: The partial lateral pharyngectomy

Concurrent radiochemotherapy in advanced hypopharyngeal cancer

Treatment results and prognostic factors in locally advanced hypopharyngeal cancer

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