Carcinoma of the Vagina—Experience at the Princess Margaret Hospital (1974-1989)

Prognostic Factors in Primary Vaginal Cancer: A Single Institute Experience and Review of Literature

“…In our group, 5-year OS and DFS rates for squamous cell carcinoma were 52.9 and 64.1 %, comparable to 68 % reported by Fleming et al [13]. Median DFS for adenocarcinoma was only 20.5 months in our group, as evidenced by Chyle et al However, Kirkebride et al [14] reporting from Princess Margaret Hospital and Platta et al [8] failed to support an advantage for squamous cell histology.…”

“…1, 2, 3). Total dose in EqD2, of[70 Gy has been demonstrated to have a better cause specific survival by authors like Lian et al, and Kirkbride et al [5,14]. In our study, better 5-year OS (67.1 vs. 38.9 %; p 0.151) and DSS (80.5 vs. 65.0 %; p 0.380) were observed in patients who received a EqD2 [ 70 Gy (Figs.…”

Patterns of failure in squamous cell carcinoma of the vagina treated with definitive radiotherapy alone: What is the appropriate treatment volume?

“…Radiotherapy is generally regarded as the treatment of choice and we must continue to improve our understanding of treatment techniques and results. The parameters that influence results of radiation treatment include stage [1][2][3], positive nodes [3,4], overall treatment time [2], location (proximal better than distal) [5], histopathology [6], and radiotherapy implant technique [4]. Two external-beam techniques are commonly used: the four-field (box) and the two-field (anterior and posterior) approach.…”

Differential tissue-specific protein markers of vaginal carcinoma

“…The only established prognostic factor is tumour stage. It has been suggested that vaginal and cervical carcinomas share a common aetiology, because vaginal tumours tend to occur as a second primary malignancy in patients with a history of cervical dysplasia and/or neoplasia even after hysterectomy for these disorders (Choo and Anderson, 1982;Eddy et al, 1991;Kirkbride et al, 1995). Cervical squamous carcinomas are strongly associated with human papillomavirus (HPV) infection, with a prevalence of almost 100% (Bosch and Munoz, 2002).…”