Carcinoma of the Vagina

Beller, U.; Benedet, J.L.; Creasman, William T.; Ngan, Hextan Y.S.; Quinn, Michael; Maisonneuve, Patrick; Pecorelli, Sërgio; Odicino, Franco; Heintz, A.P.M.

doi:10.1016/s0020-7292(06)60029-5

Cited by 72 publications

(24 citation statements)

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“…Primary carcinoma of the vagina (PCV) is a rare malignancy, comprising only 1–2% of the malignancies of the female genital tract (Beller et al , 2006). The most prevalent histological type of PCV is squamous cell carcinoma (SCC).…”

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confidence: 99%

“…The most prevalent histological type of PCV is squamous cell carcinoma (SCC). Primary carcinoma of the vagina mostly affects women over 60 years of age and has a poor prognosis (Beller et al , 2006; Hellman et al , 2006). Due to its rarity, biological and prognostic factors of PCV have not been frequently studied, in contrast to other malignancies of the female genital tract.…”

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confidence: 99%

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Human papillomavirus, p16INK4A, and Ki-67 in relation to clinicopathological variables and survival in primary carcinoma of the vagina

et al. 2014

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Background:This study aimed to determine human papillomavirus (HPV) status and to investigate p16INK4A and Ki-67 expression and their correlation with clinical parameters and survival in women with primary carcinoma of the vagina (PCV).Methods:The presence of HPV DNA was evaluated by PCR. Genotyping was performed by Luminex in 68 short-term (⩽2 years) and long-term (⩾8 years) PCV survivors. p16INK4A and Ki-67 expression was evaluated by immunohistochemistry.Results:Human papillomavirus DNA was detected in 43% of patients, the majority (63%) of whom were HPV16 positive. High p16INK4A expression was significantly correlated with low histopathological grade (P=0.004), HPV positivity (P=0.032), and long-term survival (P=0.045). High Ki-67 expression was negatively correlated with histopathological grade (P<0.001) and tumour size (P=0.047). There was an association between HPV positivity and low histopathological grade, but not between HPV positivity and survival.Conclusion:High p16INK4A expression was associated with long-term survival, but the only independent predictors for survival were tumour size and histopathological grade. Our results indicate that p16INK4A and Ki-67 expression might be useful in tumour grading, and that it might be possible to use p16INK4A expression as a marker for HPV positivity, but this has to be further elucidated.

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Human papillomavirus, p16INK4A, and Ki-67 in relation to clinicopathological variables and survival in primary carcinoma of the vagina

et al. 2014

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“…[8] Primary invasive carcinoma of the vagina is predominantly a disease of elderly women; 70-80% of cases are diagnosed in women older than 60 years. [9] Human papillomavirus (HPV) infection is one of the etiology for vaginal cancer with prevalence rate of 60-65%. [10] HPV-induced vaginal lesions are thought to arise in areas of squamous metaplasia that develop during healing of mucosal abrasions caused by coitus, tampon use, chronic pessary use, or other trauma.…”

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confidence: 99%

Vaginal vault carcinoma as second primary in a treated case of ovarian cancer

Shrivastava

Barmon²,

Kataki³

et al. 2012

J Mid-life Health

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With the advances in the treatment of cancer, the chances of survival have increased today. The five-year relative survival rate is about 66%. With the increasing survival rate, it is important to identify the late effects of cancer and its therapy. One of the most serious events experienced by cancer survivors is the diagnosis of a new cancer. Case: A 32-year-old unmarried female diagnosed as ovarian cancer in the year 2010. She was treated with three cycles of chemotherapy followed by surgery. Histopathology was well-differentiated adenocarcinoma. She received three more cycles of chemotherapy after surgery. She was under follow-up and developed vaginal vault carcinoma after a disease-free interval of 2 years. The biopsy was suggestive of squamous cell carcinoma. She was treated with radiation for vaginal cancer successfully. This case indicates that female gynecological cancers with different histology may occur in minimum period of interval even in the absence of any predisposing factors like human papilloma virus infection.

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“…1,2 The overall 5-year survival rates have risen by 15% over a 40-year period, primarily due to earlier diagnosis and the advances in irradiation techniques. 3,4 Surgical excision has been advocated only in patients with early disease presenting with small lesions. Radiation therapy is generally recommended when a curative surgical approach is not technically feasible or when surgery would risk major compromise of bladder, bowel, or vaginal function.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7] However, 5-year survival in advanced stages is still poor, being 52.2% for patients with stage II, 42.5% for patients with stage III, and 20.5% for patients with stage IVA disease. 4 Recently, concurrent chemoradiation therapy (CCRT) has been found To yield superior survival in patients with locally advanced vaginal carcinoma (stages II to IVA) and it has therefore been considered as primary treatment for such patients. 8 We present a treatment alternative to traditional radiation therapy in the nonsurgical management of vaginal cancer and review our experience with patients with primary squamous cell carcinoma of the vagina who received CCRT.…”

Section: Introductionmentioning

confidence: 99%