Carcinoma of thyroid following irradiation for medulloblastoma

Andrew, Douglas S.; Kerr, Ian F.

doi:10.1016/s0009-9260(65)80060-5

Cited by 24 publications

(3 citation statements)

References 5 publications

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“…The risk of neoplastic change in the thyroid is increased after exposure to radioactive fallout and in children who have received radiotherapy to the neck and mediastinum. [24][25][26] Three cases of thyroid carcinoma have been reported 7-12 years after irradiation for medulloblastoma.27 28 The raised TSH values in association with the radiation damage to the thyroid may be an important factor in carcinogenesis29 and treatment with thyroxine to suppress TSH may be appropriate in these patients.…”

Section: Discussionmentioning

confidence: 99%

Growth and endocrine function after treatment for medulloblastoma.

Brown¹,

Lee²,

Eden³

et al. 1983

Archives of Disease in Childhood

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SUMMARYChildren with medulloblastoma in Bristol are treated surgically and with craniospinal irradiation, and in some cases chemotherapy. Thirteen medium or long term survivors were investigated to determine their growth and endocrine function. Their rate of growth was considerably reduced through the first year of their illness and after spinal irradiation spinal growth was poor. Nine children developed growth hormone deficiency. They were clinically euthyroid but 7 had raised basal thyroid stimulating hormone values. Gonadal function was abnormal in all but the youngest child. The rate of survival is increasing in children with medulloblastoma but this is associated with appreciable endocrine abnormalities. Some of these problems are present shortly after treatment ends but others may develop later and long term surveillance is therefore essential.Cerebral tumours are the second most common malignancy of childhood and a quarter of these are medulloblastomas

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Section: Discussionmentioning

confidence: 99%

Growth and endocrine function after treatment for medulloblastoma.

Brown¹,

Lee²,

Eden³

et al. 1983

Archives of Disease in Childhood

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“…The risk of thyroid cancer persists throughout the adult life of at-risk survivors. There are case reports of thyroid carcinoma developed 7-12 years after irradiation for medulloblastoma ( 27 , 28 ). The Children’s Oncology Group currently recommends yearly examination of the thyroid gland via careful palpation.…”

Section: Endocrinologic-hormonal Complications Of Posterior Fossa Tummentioning

confidence: 99%

Endocrinologic Consequences of Pediatric Posterior Fossa Tumours

Bereket

2015

Jcrpe

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Intracranial tumors are the second most frequent malignancies in children and posterior fossa is a common location for these neoplasias during childhood. Recent advances in surgical techniques, radiotherapy and chemotherapy resulted in dramatic increase in the survival rates of these children, however they are still source of a significant morbidity and mortality. Endocrinological complications and late sequelae of childhood posterior fossa tumours are common among the survivors of these tumours and include growth retardation, hypothyroidism, pubertal disorders, gonadal dysfunction and osteopenia. These complications have significant impact on the quality of life of the survivors of childhood posterior fossa tumours. In this paper, the frequency, etiology, and management of these complications will be reviewed.

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“…sarcomas and thyroid carcinomas occurring within the irradiated portals. Thyroid carcinoma has been reported after craniospinal irradiation for medulloblas toma presumably to the exit of the spinal portal [75,76]. Given the potential long latent period for the develop ment of secondary neoplasms, close follow-up with atten tion to all tissues in the irradiated portals will be needed over the next several years to determine the true risk of radiation-induced malignancies.…”

Section: Second Malignancies Following Radiation O F the Central Nervmentioning

confidence: 99%

Short- and Long-Term Complications of Radiation Therapy for Pediatric Brain Tumors

Donahue

1992

Pediatr Neurosurg

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Brain tumors are the second most common malignancy of childhood after acute lymphocytic leukemia. Improvements in therapy have led to increased survival. It is estimated that by the year 2000 there will be approximately 200,000 survivors of childhood cancer. A proportion of these will have survived a central nervous system malignancy. As more children survive, complications of treatment are increasingly recognized. This paper reviews the spectrum of radiation-induced complications, both short- and long-term. Their frequency and characteristics will be reviewed as well as suggestions made to decrease their incidence.

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Carcinoma of thyroid following irradiation for medulloblastoma

Cited by 24 publications

References 5 publications

Growth and endocrine function after treatment for medulloblastoma.

Growth and endocrine function after treatment for medulloblastoma.

Endocrinologic Consequences of Pediatric Posterior Fossa Tumours

Short- and Long-Term Complications of Radiation Therapy for Pediatric Brain Tumors

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