Carcinoma showing thymus-like differentiation (CASTLE) of the salivary gland: Report of 2 cases of a hitherto under-recognized extrathyroid counterpart

Yamamoto, Hidetaka; Kusafuka, Kimihide; Iwasaki, Takanori; Nogami, Miwako; Hongo, Takahiro; Yasumatsu, Ryuji; Oda, Yoshinao

doi:10.1016/j.prp.2021.153646

Cited by 7 publications

(15 citation statements)

References 19 publications

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“…However, keratinocytes were clearly identified in few cases on cytology. 13,15,17,20 In our case, there was no evidence of keratinization, squamous pearls, Hassall's corpuscles, or intercellular bridges in either cytology or histology. The lymphoepithelioma type of CASTLE may show indistinct keratinization, as in our case.…”

Section: Discussionmentioning

confidence: 40%

“…1,20 Regarding glandular differentiation, mucin-producing cells may appear in thyroid CASTLE. 12 However, in our review, no mucous cells were detected, 15,20 also in our case.…”

Section: Discussionmentioning

confidence: 99%

“…Only nine cases of CASTLE arising in the major salivary glands have been reported in the literature published in English (Table 1). 13–20 Table 1 summarizes the case reports related to CASTLE arising from salivary glands, focusing on squamous/glandular differentiation. Histologically, there were four cases with keratinization or Hassall's corpuscle, and one case had atypical cells suspicious for SCC on cytology.…”

Section: Discussionmentioning

confidence: 99%

“…Individual 1). [13][14][15][16][17][18][19][20] for SCC on cytology. However, keratinocytes were clearly identified in few cases on cytology.…”

Section: Discussionmentioning

confidence: 99%

“…The lymphoepithelioma type of CASTLE may show indistinct keratinization, as in our case. 1,20 Regarding glandular differentiation, mucin-producing cells may appear in thyroid CASTLE. 12 However, in our review, no mucous cells were detected, 15,20 also in our case.…”

Section: Discussionmentioning

confidence: 99%

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Carcinoma showing thymus‐like differentiation of the parotid gland: The brief report of cytomorphology and review of the literature

Uchiyama

Terada

Tachibana

et al. 2022

Diagnostic Cytopathology

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Here, we report an extremely rare case of carcinoma with thymus‐like differentiation (CASTLE) of the parotid gland. CASTLE is a rare malignant epithelial tumor with thymic epithelial differentiation that arises in the thyroid gland or perithyroidal soft tissue. CASTLE of salivary gland origin is rare, with only nine published case reports to date (reported as “CASTLE” or “thymic carcinoma”). It is critical to diagnose salivary gland tumors using fine needle aspiration cytology. However, this tumor is rare, and there have been few studies on its cytomorphological features. Therefore, it is important to understand the cytological diagnostic characteristics of CASTLE. Herein, we review the cytological features and diagnostic characteristics of salivary gland CASTLE. We also report the genotype results obtained using targeted exome sequencing, which we analyzed with DNA extracted from formalin‐fixed paraffin‐embedded tissue.

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Section: Discussionmentioning

confidence: 40%

“…1,20 Regarding glandular differentiation, mucin-producing cells may appear in thyroid CASTLE. 12 However, in our review, no mucous cells were detected, 15,20 also in our case.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Individual 1). [13][14][15][16][17][18][19][20] for SCC on cytology. However, keratinocytes were clearly identified in few cases on cytology.…”

Section: Discussionmentioning

confidence: 99%