Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina

Evaluation of P53, E-cadherin, Cox-2, and EGFR protein imunnoexpression on prognostic of resected gallbladder carcinoma

“…In other words, the lower the tissue expression of E-cadherin was, the greater the proportions of undifferentiated tumors, metastases (M) and thickness of invasion of the viscera (T) were. However, no prognostic correlation between E-CD expression and survival was found in the present study, just as in Roa et al 24 . There was a prognostic correlation only in the univariate analysis, and this was not maintained in the univariate analysis possibly because of the sample size.…”

“…In the form of "biomarkers", these proteins might further expand the spectrum of knowledge of their prognostic factors and, moreover, might contribute in some way towards studies on specific drugs with the capacity to act on certain receptors. In relation to the prognosis for gallbladder carcinoma, little has been published recently on the prognostic implications of the proteins P53 1 , 2 , 9 , 23 , 25 , E-cadherin (E-CD) 11 , 24 , cyclooxygenase 2 (COX-2) 10 , 14 and epidermal growth factor receptor (EGFR) 4 , 6 , 8 , 26 .…”

Cáncer de vesícula biliar durante el trienio 2001-2003 en el Hospital Base de Osorno

“…En la mayoría de los casos su curso es inevitablemente fatal, fundamentalmente por su diagnóstico tardío, sin embargo, en la actualidad existen estudios orientados al diagnóstico precoz de ella mediante el uso de marcadores serológicos, con resultados preliminares alentadores 10,11 . Por otra parte, estudios actuales recomiendan la colecistectomía en pacientes con colelitiasis sintomática antes de los 40 años en las mujeres y antes de los 50 en hombres, lo que disminuiría el riesgo de desarrollar una neoplasia 11 .…”