Carcinoma urotelial de tracto urinario superior: 114 casos con largo seguimiento

Izquierdo, Laura; Truan, David; Álvarez-Vijande, R.; Alcaraz, Antonio

doi:10.1016/j.acuro.2009.11.004

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Estudo de 114 pacientes com longo seguimento de carcinoma urotelial de trato superior exibe que o grau histológico e o estágio patológico são tópicos prognósticos que influenciam a evolução tumoral e a taxa de mortalidade relacionado ao carcinoma urotelial no trato urinário superior (Izquierdo et al, 2010).…”

Section: Discussionunclassified

Carcinoma Urotelial Em Ureter Remanescente Após Nefrectomia Por Neoplasia De Pelve Renal: Um Relato De Caso

Muniz,

Silva,

Rabelo

2024

Rev. Contemp.

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Relatamos o caso de um homem de 57 anos com neoplasia urotelial submetido somente à nefrectomia do rim esquerdo, porém, a ureterectomia não foi realizada. O paciente fez seguimento e após 2 anos apresentou hematúria. Ressonância magnética evidenciou dilatação em ureter esquerdo e massa sólida. Além disso, essa formação neoplásica projetava-se para o interior da bexiga. Os dados foram adquiridos através da análise do histórico clínico, documentação fotográfica dos procedimentos diagnósticos realizados e revisão de fontes bibliográficas. O caso descrito e as publicações levantadas destacam a abordagem terapêutica de uma patologia rara. Após o tratamento, o acompanhamento visa identificar recidivas e possibilitar tratamento cirúrgico curativo devido ao risco elevado de recorrência avançada.

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Section: Discussionunclassified

Carcinoma Urotelial Em Ureter Remanescente Após Nefrectomia Por Neoplasia De Pelve Renal: Um Relato De Caso

Muniz,

Silva,

Rabelo

2024

Rev. Contemp.

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“…The prognosis of UTUC remains unpredictable in many instances. Approximately one third of UTUC patients die from their tumour after five years of follow-up and the commonly utilised prognostic factors are unable to accurately predict individual tumour behaviour [ 18 ]. Therefore predicting disease progression in a specific patient remains a challenge.…”

Section: Discussionmentioning

confidence: 99%

Prognostic microRNAs in upper tract urothelial carcinoma: multicenter and international validation study

et al. 2017

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ObjectiveTo validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients.Patients and MethodsMulticenter, international and retrospective study of formalin-fixed paraffin-embedded tissue samples from 103 UTUC patients (45 progressing and 58 non-progressing) who underwent radical nephroureterectomy. Total RNA was isolated and reverse transcribed. The expression of target miRNAs (miR-31-5p and miR-149-5p) and the endogenous control miR-218-5p was evaluated in all samples by reverse transcription quantitative PCR. Normalized miRNA expression values were evaluated by multivariate forward stepwise Cox regression analysis. Kaplan Meier curves were used to discriminate between two groups of patients with a different probability of tumour progression.ResultsThe mean age (range) of the series was 67 (33-94) years. Overall, 45 patients (43.7%) developed tumour progression and 32 patients (31.2%) died, 20 of these (62.5%) due to their UTUC, after a median follow-up of 36 months. The mean time for tumour progression and cancer-specific survival were 15 and 20 months, respectively. Five year tumour progression free survival and cancer-specific survival were 58% for ≤ pT2, 36% for pT3 and 0% for pT4 and 67.8% for ≤ pT2, 50.6% for pT3 and 0% for pT4, respectively. In the multivariate analysis, expression of miR-31-5p was found to be an independent prognostic factor of tumour progression (HR 1.1; 95% CI 1.039-1.273; p=0.02). Kaplan Meier curve shows that miR-31-5p expression values are able to discriminate between two groups of UTUC patients with a different probability of tumour progression (p=0.007).ConclusionsWe have been able to validate our previous results in an independent multicentre international cohort of UTUC patients, suggesting that miRNA-31-5p could be a useful prognostic marker of UTUC progression. The application of miRNA expression values to clinical practice could refine the currently used clinicopathological-based approach for predicting UTUC patients’ outcome.

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“…Clinically, UC is a multifocal malignant disease located in the uroepithelium. Recent data demonstrate that 2–4% of patients with a bladder UC also present with an upper urinary tract tumor (UUTT); the incidence of UUTT is 2–6% among patients who undergo a radical cystectomy for UC ( 3 ). Higher recurrence rates and more aggressive biological behavior of UC in dialysis-dependent patients have been confirmed compared with individuals without ESRD ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Metachronous urothelial carcinoma of whole urinary tract in a dialysis-dependent patient: A case report

2016

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Numerous studies have reported an association between end-stage renal disease (ESRD) and malignancy. The predominant malignant tumor that occurs in patients with ESRD in Asian countries is urothelial carcinoma (UC). According to recent research, cases of UC in dialysis-dependent patients are associated with higher recurrence rates and more aggressive biological behavior compared with patients without ESRD. The necessity of 1-step total urinary tract exenteration for dialysis-dependent patients with UC is advocated by certain studies. The current study reports a case of metachronous bladder cancer and bilateral upper urinary tract tumor in a dialysis-dependent patient. Three separate surgeries were performed to remove the bladder, and left and right urinary tract, respectively. The question of whether the stepwise strategy or the 1-step surgery should be selected for such special cases remains in debate.

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Carcinoma urotelial de tracto urinario superior: 114 casos con largo seguimiento

Cited by 4 publications

References 22 publications

Carcinoma Urotelial Em Ureter Remanescente Após Nefrectomia Por Neoplasia De Pelve Renal: Um Relato De Caso

Carcinoma Urotelial Em Ureter Remanescente Após Nefrectomia Por Neoplasia De Pelve Renal: Um Relato De Caso

Prognostic microRNAs in upper tract urothelial carcinoma: multicenter and international validation study

Metachronous urothelial carcinoma of whole urinary tract in a dialysis-dependent patient: A case report

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