Carcinomas of the Urinary Bladder with Deceptively Benign-Appearing Foci

Talbert, Matthew; Young, Robert H.

doi:10.1097/00000478-198905000-00004

Cited by 104 publications

(75 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The case shares histological features with minimal deviation adenocarcinoma of the uterine cervix, although this was not identical to uterine minimal deviation adenocarcinoma. Talbert and Young reported a case of a nested variant of urothelial carcinoma with minimal deviation adenocarcinoma-like features [3]. To our knowledge, there are no convincing reports of urinary bladder minimal deviation adenocarcinoma without urothelial carcinoma component.…”

Section: Discussionmentioning

confidence: 85%

“…Urothelial carcinoma appears rarely as a deceptively benign appearance [3,4]. Talbert and Young reported a case of nested variant of urothelial carcinoma with minimal deviation adenocarcinoma-like features [3]. Herein, we report a pure primary adenocarcinoma of the urinary bladder with minimal deviation adenocarcinoma-like features.…”

Section: Introductionmentioning

confidence: 87%

“…Nephrogenic adenoma, cystitis glandularis and Müllerianosis are important differential diagnoses in bladder adenocarcinoma [2]. Urothelial carcinoma appears rarely as a deceptively benign appearance [3,4]. Talbert and Young reported a case of nested variant of urothelial carcinoma with minimal deviation adenocarcinoma-like features [3].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Well-Differentiated Adenocarcinoma of the Urinary Bladder with Minimal Deviation Adenocarcinoma-Like Features

M¹

2013

J Cytol Histol

View full text Add to dashboard Cite

Urinary bladder adenocarcinoma is an uncommon disease. The histological diagnosis of bladder adenocarcinoma is usually straightforward. However, bladder carcinoma rarely shows benign-mimicking features. We report on a 64-year-old woman who was diagnosed with urinary bladder adenocarcinoma, which was well differentiated with the features of minimal deviation adenocarcinoma. Most of the tumor cells were slightly atypical, and the tumor was differentiated barely from the benign disease. Careful examination was necessary for a correct diagnosis. The pathology comprised invasive foci with desmoplastic reaction in the extravesicular adipose tissue.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 87%

See 1 more Smart Citation

Well-Differentiated Adenocarcinoma of the Urinary Bladder with Minimal Deviation Adenocarcinoma-Like Features

M¹

2013

J Cytol Histol

View full text Add to dashboard Cite

show abstract

“…The first description of histologic features of NVUCwaspresentedin1979byStern,whoconsideredittobeabenigntumor [2].TalbertandYoung [3], ten years later (1989), redefined the tumor as amalignantone.Accordingtotheliterature,based onanalysisof75cases(describedin15publications), NVUChasapredilectionfortheurinarybladderand inrarecasestheureter.Pusztaszariet alreportedcoexistenceofNVUCintherenalpelvisandintheureter [4],andLau [5]andTripodiet al [6]described thetumorlocatedonlyintherenalpelvis.…”

Section: Discussionmentioning

confidence: 99%

Nested variant of urothelial carcinoma of renal pelvis – a

Kuzaka¹,

Pastewka²,

Faryna³

et al. 2014

pjp

View full text Add to dashboard Cite

show abstract

“…These tumours, when showing focal or diffuse immunoreactivity for cytokeratin 20, may be associated with local recurrence, a short disease-free period and focal superficial stromal invasion [2][3][4][5][6][7][8]. Extensive invasive UC with neoplastic cells showing minimal or mild cytological atypia, as seen in UNLMP or UCLG, have been described as deceptively benignappearing TCC, nested or microcystic TCC [9][10][11][12]. Despite the minimal or mild cytological atypia, these neoplasms are occasionally associated with an aggressive clinical course and death.…”

Section: Introductionmentioning

confidence: 99%

Histopathological and immunohistochemical study of papillary urothelial neoplasms of low malignant potential and grade associated with extensive invasive low‐grade urothelial carcinoma

Kien¹,

Elmontaser²,

Perkins³

et al. 2004

BJU International

View full text Add to dashboard Cite

OBJECTIVETo report five cases of papillary urothelial neoplasm of low malignant potential (UNLMP) and papillary urothelial carcinoma of low grade (UCLG) associated with extensive muscle invasion, and to investigate the clinical and histopathological presentation and their immunohistochemical properties.MATERIALS AND METHODSConsecutive cystectomy and correlating transurethral resection (TUR) of urinary bladder tumour specimens were reviewed to identify cases of UCLG having extensive invasion into the urinary bladder wall. All specimens were stained immunohistochemically, as were those from 10 control cases having reactive urothelium or superficial UNLMP. The clinical charts were reviewed.RESULTSOf a total of 95 cystectomy cases there were four of UNLMP or UCLG with extensive invasion. An additional case was added from our consultation file. All five cases had biopsies misdiagnosed as benign lesions or prostatic adenocarcinoma. The superficial invasive components consisted of UCLG conforming to the previously described entities of nested transitional cell carcinoma (TCC), microcystic or deceptively benign‐appearing TCC. Immunostaining for cytokeratin 20, MIB‐1 and p53 was similar to reactive epithelia, whereas E‐cadherin immunoreactivity was slightly different, with focal negativity compared with extensive immunoreactivity in invasive vs noninvasive UCLG. Four patients developed distant metastases; three died within a follow‐up of 3 years.CONCLUSIONSUNLMP and UCLG that widely and deeply invade the bladder accounted for 4% of urothelial carcinoma (UC) in cystectomy specimens and commonly pose diagnostic problems in superficial TUR specimens. From this study with few cases the diagnosis of this entity in superficial biopsies is aided by an awareness of it and by identifying ‘benign appearing’ nests of urothelial cells which are deeply seated in the stroma. Immunostaining is unlikely to be very useful.

show abstract

Carcinomas of the Urinary Bladder with Deceptively Benign-Appearing Foci

Cited by 104 publications

References 0 publications

Well-Differentiated Adenocarcinoma of the Urinary Bladder with Minimal Deviation Adenocarcinoma-Like Features

Well-Differentiated Adenocarcinoma of the Urinary Bladder with Minimal Deviation Adenocarcinoma-Like Features

Nested variant of urothelial carcinoma of renal pelvis – a

Histopathological and immunohistochemical study of papillary urothelial neoplasms of low malignant potential and grade associated with extensive invasive low‐grade urothelial carcinoma

Contact Info

Product

Resources

About