Carcinosarcoma de novo of the parotid gland: Case report

Taki, Nizar H.; Laver, Nora; Quinto, Tobi; Wein, Richard O.

doi:10.1002/hed.22900

Cited by 19 publications

(15 citation statements)

References 9 publications

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“…Carcinosarcoma has been described in the gastrointestinal tract, upper and lower respiratory tracts, urogenital tract, breast and skin [4], [5]. However, its occurrence in the sinonasal tract is extremely rare [4].…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the maxillary sinus: A rare case report

Hasnaoui

Anajar

Tatari

et al. 2017

Annals of Medicine &Amp; Surgery

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IntroductionCarcinosarcoma is a highly malignant tumor characterized by dual malignant histologic differentiation of epithelial and mesenchymal components. The tumor is extremely rare in the sinonasal tract, with only 13 cases reported since 1957 in the literature.Presentation of caseWe report a case of a 55-year-old man with right-sided face pain revealed a mass in the right maxillary sinus and nasal cavity. A large incisional biopsy from the nasal cavity concluded the diagnosis of carcinosarcoma. The patient was treated with chemoradiation, but no significant effect was obtained. The patient died 4 months after initial examination.DiscussionIn our case, the patient consulted late with a large tumor which darkens his prognosis. According to some authors, this histological type of tumors is known by local recurrences and its lethal metastases. Prognosis is related to location, tumor size, the invasion and stage of disease. Wide surgical excision is the treatment of choice. Radiotherapy can be discussed in inoperable cases.ConclusionThis is an aggressive tumor, rapidly progressive with a poor prognosis. The management of this rare condition remains undetermined.

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Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the maxillary sinus: A rare case report

Hasnaoui

Anajar

Tatari

et al. 2017

Annals of Medicine &Amp; Surgery

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“…Carcinosarcoma has been described in the gastrointestinal tract, upper and lower respiratory tracts, urogenital tract, breast and skin [4,5]; however, its occurrence in the sinonasal tract is extremely rare [4]. The most common site for carcinosarcoma in the head and neck region is the parotid gland, followed by the submandibular gland [17].…”

Section: Discussionmentioning

confidence: 99%

“…The mesenchymal component comprises a sarcomatoid stroma, such as a chondrosarcoma, or osteosarcoma [1], but fibrosarcoma, leiomyosarcoma [2], or even liposarcoma [3] is possible. Carcinosarcoma may arise in various anatomic sites, such as the salivary glands, respiratory tract, upper gastrointestinal tract, and female reproductive organs [4,5]. Carcinosarcomas of the salivary glands (the most common head and neck sites) are aggressive with a tendency for local recurrence and commonly, distant metastasis to the lungs or brain, usually within a period of 30 months [1].…”

Section: Introductionmentioning

confidence: 99%

A case–control analysis of survival outcomes in sinonasal carcinosarcoma

Patel

Vázquez

Plitt

et al. 2015

American Journal of Otolaryngology

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“…Carcinosarcoma ex pleomorphic adenoma refers to a carcinosarcoma that has developed in the background of a pleomorphic adenoma. On the other hand, a new lesion arising in the absence of a preexisting benign mixed tumor is termed carcinosarcoma de novo …”

Section: Introductionmentioning

confidence: 99%

Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy

et al. 2019

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Objectives/Hypothesis: Carcinosarcomas represent a rare entity of mixed malignant tumors of the salivary gland with limited evidence regarding management strategies. We aim to demonstrate the incidence, prognostic factors, and conduct a survival analysis for this aggressive malignancy.Study Design: Retrospective database review. Methods: The Surveillance, Epidemiology, and End Results database was queried for all cases of major salivary carcinosarcoma and its incidence from 1973 to 2015 to identify 66 patients.Results: The incidence of this tumor was 0.02 cases per 1 million, with a rising number of absolute cases in the past 2 decades. The parotid gland was the most common site (78.8%) of involvement. The 5-year overall survival was 37% and 5-year disease-specific survival was 62%. Surgery was most common management strategy (95.5%), with total parotidectomy and facial nerve sacrifice procedures for those with parotid disease. Radiotherapy was commonly performed (75.8%) and chemotherapy use was rare (18.2%). Patients with distant metastasis had a greater than threefold increase in mortality, and those with total parotidectomy surgery had decreased mortality.Conclusions: Carcinosarcomas of major salivary glands are extremely rare and highly aggressive tumors. We recommend prompt surgical management and postoperative radiation for this tumor with a poor prognosis.

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Carcinosarcoma de novo of the parotid gland: Case report

Abstract: Review of the literature supports combined modality, surgery with postoperative radiation, as the standard of care for this malignancy, although the long-term prognosis for these patients is unclear.

Cited by 19 publications

References 9 publications

Carcinosarcoma of the maxillary sinus: A rare case report

Carcinosarcoma of the maxillary sinus: A rare case report

A case–control analysis of survival outcomes in sinonasal carcinosarcoma

Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy

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