Carcinosarcoma of Breast Mimicking Breast Abscess

Muslim, Shahnawaz; Prasad, Geeta; Alam, Izhar; Singh, Shambhu Kumar; Nasrin, Nasrin

doi:10.1007/s13193-018-0777-z

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…The clinical symptoms of breast carcinosarcoma are similar to invasive ductal carcinoma, and include the presence of a large painful mass, nipple discharge, nipple depression, and skin ulceration (7,8,12,14). One study reported a case of carcinosarcoma presenting as a breast abscess (15). In the present case, the affected mammary gland showed the signs of local inflammation, including redness and swelling of the skin overlying the mass.…”

mentioning

confidence: 57%

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

Guo

Sun

Zhang

et al. 2019

Iran Red Crescent Med J

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Introduction: Breast carcinosarcoma is an extremely rare breast tumor comprising two distinct components, a carcinomatous component and a non-epithelial component of mesenchymal origin. It is a subtype of metaplastic carcinoma with a difficult preoperative diagnosis. Case Presentation: We present the case of a 68-year-old postmenopausal woman with squamous metaplasia coexisting with adenocarcinoma in the epithelial component of a breast carcinosarcoma. She has been admitted in

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mentioning

confidence: 57%

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

Guo

Sun

Zhang

et al. 2019

Iran Red Crescent Med J

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“…Due to the specific histologic feature, breast carcinosarcoma may have different biological characteristics when compared with IDC. Because of the rarity of breast carcinosarcoma, previous publications about this disease were a few small sample size retrospective analyses [ [8] , [9] , [10] , [11] , [12] , [13] , [14] ] and a few case reports [ [15] , [16] , [17] , [18] , [19] , [20] ]. From these limited studies, it appears that breast carcinosarcoma is always aggressive, poorly differentiated, and hormone receptor-negative [ 8 , 10 ].…”

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confidence: 99%

Clinicopathological characteristics and survival outcomes in breast carcinosarcoma: A SEER population-based study

et al. 2020

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Objectives Carcinosarcoma of the breast is a rare disease. Its clinicopathological features and prognosis are not well defined. The aim of this study was to compare the clinicopathological features and clinical outcome between breast carcinosarcoma and breast invasive ductal carcinoma (IDC). Materials and methods Patients with breast carcinosarcoma and breast IDC were identified through the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. Then a comparison was conducted between these two groups. Propensity score matching (PSM) was performed to balance the effects of baseline clinicopathological differences. The Cox proportional hazard model was used to identify potential prognostic factors of breast carcinosarcoma. Results In total, we identified 63 patients with breast carcinosarcoma and 200,596 cases with breast IDC. Comparing with IDC, breast carcinosarcoma was significantly correlated with higher grading, higher staging, larger tumor size, lower lymph node involvement, and a higher proportion of triple negative breast cancer (TNBC), suggesting a significantly worse clinical outcome. After adjusting for the uneven clinicopathological variables with PSM, significant differences were still observed between these two histology types. Subgroup analysis further showed that carcinosarcoma-TNBC has an inferior clinical outcome compared with IDC-TNBC. Finally, we identified independent prognostic factors, namely, stage, tumor size, and distant metastasis. Conclusion It is concluded that breast carcinosarcoma has distinct clinicopathological features and a significantly worse clinical outcome than common IDC.

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Carcinosarcoma of the breast: Facing the challenge of a rare nosologic entity

Mastoraki,

Tsamopoulou,

Stamatis

et al. 2025

World J Clin Cases

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Carcinosarcoma (CS), also known as metaplastic breast carcinoma with mesenchymal differentiation, is one of the five distinct subtypes of metaplastic breast cancer. It is considered as a mixed, biphasic neoplasm consisting of a carcinomatous component combined with a malignant nonepithelial element of mesenchymal origin without an intermediate transition zone. Although cellular origin of this neoplasm remains controversial, most researchers declare that neoplastic cells derive from a cellular structure with potential biphasic differentiation. Despite recent research on the therapeutic strategies against CS neoplastic disorders, surgical resection appears the only potentially curative approach. Since CS metastasize by the lymphatic route, axillary assessment with sentinel lymph node biopsy and/or axillary lymph node dissection is always implemented. Nevertheless, the tumor also presents a hematogenous metastatic pattern including pleural, pulmonary, liver, brain and less commonly bone metastases. Thus, surgical removal of breast CS does not necessarily ensure patient’s long-term recovery. Moreover, alternative therapies, such as radio- and chemotherapy proved insufficient and 5-year survival rate is limited. Nevertheless, there is evidence that following surgery, the combination of radio and chemotherapy is associated with a better prognosis than either treatment alone. The aim of this review is to evaluate the results of surgical treatment for breast CS with special reference to the extent of its histological spread. Clinical features, histogenesis, morphological and immunochemical findings are discussed, while the role of current diagnostic and therapeutic management of this aggressive neoplasm is emphasized.

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Carcinosarcoma of Breast Mimicking Breast Abscess

Cited by 4 publications

References 10 publications

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

Breast Carcinosarcoma: The Report of a Unique Case Including Fibrosarcoma and Metaplasia of Squamous Carcinoma with Adenocarcinoma; a Case Report and the Literature Review

Clinicopathological characteristics and survival outcomes in breast carcinosarcoma: A SEER population-based study

Carcinosarcoma of the breast: Facing the challenge of a rare nosologic entity

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