Carcinosarcoma of the maxillary sinus: A case report

Sanabre, Antonio Arcas; González-Lagunas, J.; Redecilla, Pere Huguet; Martín, Guillermo Raspall

doi:10.1016/s0278-2391(98)90417-7

Cited by 15 publications

(22 citation statements)

References 17 publications

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“…Carcinosarcomas of the salivary glands (the most common head and neck sites) are aggressive with a tendency for local recurrence and commonly, distant metastasis to the lungs or brain, usually within a period of 30 months [1]. Its occurrence is extremely rare in the nasal cavity and the paranasal sinuses, as indicated by the few cases reported in the literature [4,[6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Sinonasal carcinosarcoma (SN-CS), like other malignancies of the sinonasal tract, often presents with nonspecific symptoms, including facial pain, unilateral nasal obstruction and epistaxis [14]. SN-CS tends to present in the sixth decade of life and has been reported to be more common in males (3.5:1) [14].…”

Section: Introductionmentioning

confidence: 99%

“…SN-CS tends to present in the sixth decade of life and has been reported to be more common in males (3.5:1) [14]. The treatment of choice for SN-CS is wide local excision with adjuvant radiotherapy, although limited data exist for adequate comparison of treatment alternatives.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the very rare nature of this tumor, to date, the reports of SN-CS in the literature have been limited to mostly case reports [4,[6][7][8][9][10][11][12][13][14][15][16]. Here we use data from the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2010 to present the largest known cohort of SN-CS and compare survival features to case-matched cohorts of salivary gland carcinosarcoma (SG-SC), non-sinonasal carcinosarcoma (NonSN-CS), and all other head and neck carcinosarcomas (NonSNSG-CSs).…”

Section: Introductionmentioning

confidence: 99%

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A case–control analysis of survival outcomes in sinonasal carcinosarcoma

Patel

Vázquez

Plitt

et al. 2015

American Journal of Otolaryngology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A case–control analysis of survival outcomes in sinonasal carcinosarcoma

Patel

Vázquez

Plitt

et al. 2015

American Journal of Otolaryngology

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“…[15][16][17][18][19][20][21][22][23][24][25][26] We identified 5 cases of carcinosarcoma that originated in the maxillary sinus or ethmoid sinus with extension into the orbit. 15,16,19,23,26 These cases are summarized in Table 2.…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the Orbit: Report of Two Cases and Review of the Literature

et al. 2008

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Objective-To report the clinicopathologic features of 2 patients with carcinosarcoma of the orbit. Design-Case reports.Participants-Two patients with orbital carcinosarcoma were identified. Methods-Retrospective chart review with clinicopathologic correlation and literature review.Main Outcome Measures-Clinical examination, imaging studies, and histopathologic findings.Results-Two patients, a 56-year-old woman and a 91-year-old woman, with orbital carcinosarcoma were identified. Both tumors contained sarcomatous and carcinomatous components and invaded periorbital structures.Conclusions-Carcinosarcoma may arise in the orbit or extend into the orbit from the paranasal sinuses. This malignant neoplasm should be aggressively treated with a combination of surgical resection, chemotherapy, and radiation therapy.Carcinosarcoma (true malignant mixed tumor) is a biphasic tumor consisting of intermixed malignant epithelial (carcinomatous) and mesenchymal (sarcomatous) components. Carcinosarcoma has been described to arise in many tissues, including the female genital tract, 1, 2 lung,3 kidney,4 bladder, 5 esophagus, 6 biliary tract, 7 and skin. 8 There are 3 reports of carcinosarcoma arising in the orbit 9-11 and an additional case of parotid gland carcinosarcoma that metastasized to the orbit. 12 Although this is a rare orbital tumor, ophthalmologists and pathologists should be aware of the clinicopathologic features for aggressive management. We report 2 patients with carcinosarcoma of the orbit and briefly review the literature. NIH Public Access Author ManuscriptOphthalmology. Author manuscript; available in PMC 2010 November 30. Case ReportsCase 1-A 56-year-old African-American woman with hypothyroidism, but otherwise healthy, was evaluated for a 3 to 4-month history of right epiphora and a tender right orbital mass. The best-corrected vision was 20/40 − in her right eye and 20/30 − in her left eye. Examination showed a firm, tender 1×1×1-cm nodule between the nasal bone and the right medial canthus (Fig 1). There was mild edema and ecchymosis overlying the mass. Her intraocular pressures were 22 mmHg in both eyes. There was a slight limitation of the right upgaze and 2 mm of right proptosis. The remainder of the ophthalmic examination results was normal. An otolaryngologic examination performed 1 week earlier showed on direct visualization a submucosal bulge anterior to the attachment of the middle turbinate consistent with the lacrimal sac area. CT showed a 2.3×2.0×2.9-cm mass arising from the right nasofrontal recess and eroding into the ethmoid sinus, medial orbital wall, and inner table of the right frontal sinus (Fig 2). A right medial orbitotomy was performed, and the tumor was found to be posterior to the globe and adherent to the periorbita and skin. An incisional biopsy was performed, and a frozen section of the biopsy was diagnosed as spindle cell neoplasm. After examination of permanent sections, the tumor was diagnosed as carcinosarcoma. The treatment plan was extensive surgery, including orbi...

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International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Carcinosarcoma of the maxillary sinus: A case report

Cited by 15 publications

References 17 publications

A case–control analysis of survival outcomes in sinonasal carcinosarcoma

A case–control analysis of survival outcomes in sinonasal carcinosarcoma

Carcinosarcoma of the Orbit: Report of Two Cases and Review of the Literature

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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