Carcinosarcoma of the Prostate with Metastasis of Both Elements: Case Report

The Impact of Radical Prostatectomy on the Survival of Patients with Carcinosarcoma of the Prostate

“…Although we adjusted for differences in demographic and clinical features, residual confounding might be present. In addition, our data did not allow us to examine surgical volume, hospital characteristic, receipt of chemotherapy, and patient comorbidities, all of which are factors presumed to influence survival in cancer patients [17]. However, the use of cancer specific survival rather than overall survival in our study has modified the limitation to some degree.…”

“…The tumor cells from both tumor components showed monoclonality and clonal identity in all cases studied, suggesting a monoclonal origin [13][14][15]. Other theories include carcinosarcoma might developed as a equence of conmetaplastic chondromatous response which subsequently became malignant in patients with primary adenocarcinoma of the prostate [17,18]; or originate from the mesodermal vestige within the prostate [19].…”

“…The histogenesis of prostate carcinosarcoma is not completely understood, and various interpretations have been proposed for the heterogenous components of this tumor [11][12][13][14][15][16][17]. Some investigators suggested that these tumors develop as a result of undifferentiated, totipotential neoplastic cells that undergo multiple pathways of terminal differentiation into either mesenchymal or epithelial elements.…”

Prostatic carcinogenesis evoked by cellular interaction.

“…As a result ofthis study, we can offer a new epigenetic c # I (14), the concept that a directive influence from the stromal component induces patterns of adenocarcinoma formation deserves greater attention. In this regard, it is interesting to note that the epithelial cells in culture, isolated from normal or neoplastic human prostate glands, exhibited no difference in their growth responses to various hormones and growth factors (15).…”

Prostatic carcinosarcoma 15 years after combined external beam radiation and brachytherapy for prostatic adenocarcinoma: a case report

“…1,2 As prostatic sarcoma occurs more commonly at an earlier age than adenocarcinoma, it is extremely rare for a patient to have both neoplasms. 3 When these do occur together as carcinosarcoma, half of the patients have a history of prostatic adenocarcinoma. 4 We report an unusually delayed occurrence of prostatic carcinosarcoma after combined external beam radiation therapy (EBRT) and brachytherapy.…”