Carcinosarcoma of the Rectum: Report of a Rare Colorectal Malignancy and Review of the Literature

Sudlow, Alexis; Liu, Ming Ho; Waters, Geoffrey; Velchuru, Vamsi

doi:10.1155/2015/412918

Cited by 12 publications

(10 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 2 10 The carcinomatous component commonly shows reactivity to CK20 and carcinoembryonic antigen, whereas the sarcomatous component stains positively for vimentin, desmin, and smooth muscle actin. 10 The biphasic component mentioned was further emphasised by the IHC studies, with CK AE1/AE3 highlighting only the carcinomatous cell population. Further IHC studies with mesenchymal markers, including H-caldesmon, DOG1, S100, SALL4 and CD31 do not impart a specific lineage differentiation for the sarcomatous component ( figure 7 ).…”

Section: Discussionmentioning

confidence: 99%

“… 12 However, long-term benefits of neoadjuvant and adjuvant chemoradiotherapy have not yet been proven. 10 Of the eight reported rectal carcinosarcoma cases, two underwent neoadjuvant radiotherapy, one of which had recurrence, the other one had none. Two other patients underwent adjuvant treatment, one of which had documented recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…5 12 Due to the aggressive nature of this disease, strict follow-up and close monitoring is recommended. 10 12 …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Abdominotransanal resection of a strangulated rectal carcinosarcoma

et al. 2021

View full text Add to dashboard Cite

This is a case of a 75-year-old man who presented with a 7-month history of a reducible rectal mass. The patient came to the emergency department with a prolapsed necrotic bowel involving a strangulated segment with the rectal mass. He underwent an abdominotransanal resection through a combined abdominal and perineal approach. His postoperative course was unremarkable. Histopathological and immunohistochemical studies showed a rectal carcinosarcoma. Because of a state-mandated lockdown due to the COVID-19 pandemic, the patient failed to follow-up. He was later seen to have metastatic progression. Owing to the poor functional status of the patient, the shared decision of the multidisciplinary team, the patient and his family was to manage him with palliative intent.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Abdominotransanal resection of a strangulated rectal carcinosarcoma

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Histologically, carcinosarcoma consists of a mixture of an epithelial component most often a mild to high grade adenocarcinoma and a sarcomatous element of mesenchymal origin which may be differentiated or undifferentiated [ 8 ]. Further characterization of the nature of the tumour itself has been achieved through immunohistochemistry, confirming the presence of distinct components.…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the colon with extensive and extraordinary metastases detected on F-FDG18PET/CT: A case report

Maskrout

Boutaggount

Mokfi

et al. 2022

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

“…Benign and malignant epithelial neoplasms of the colon and rectum are common with colorectal cancer being the second commonest cancer in Canada[ 1 ]. Mixed tumors of the colon and rectum include a broad category of neoplasms composed of the coexistence of epithelial-adenocarcinoma and non-neuroendocrine elements such as ovarian granulosa cell tumor[ 2 ] malignant lymphoma[ 3 - 9 ], malignant melanoma[ 10 ] and mesenchymal elements such as carcinosarcoma[ 11 ] and leiomyosarcoma[ 12 ]. However, the presence of a gastrointestinal tumor with a neuroendocrine and an exocrine component in the same neoplasm was first reported by Cordier[ 13 ] in 1924.…”

Section: Introductionmentioning

confidence: 99%

Mixed epithelial endocrine neoplasms of the colon and rectum – An evolution over time: A systematic review

Kanthan¹,

Tharmaradinam²,

Asif³

et al. 2020

WJG

View full text Add to dashboard Cite

BACKGROUND Mixed tumors of the colon and rectum, composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare neoplasms. These can occur anywhere in the gastrointestinal tract and are often diagnosed incidentally. Though they have been a well-documented entity in the pancreas, where the exocrine-endocrine mixed tumors have been known for a while, recognition and accurate diagnosis of these tumors in the colon and rectum, to date, remains a challenge. This is further compounded by the different terminologies that have been attributed to these lesions over the years adding to increased confusion and misclassification. Therefore, dedicated literature reviews of these lesions in the colon and rectum are inconsistent and are predominantly limited to case reports and case series of limited case numbers. Though, most of these tumors are high grade and of advanced stage, intermediate and low grade lesions of these mixed tumors are also increasingly been reported. There are no established independent consensus based guidelines for the therapeutic patient management of these unique lesions. AIM To provide a comprehensive targeted literature review of these complex mixed tumors in the colon and rectum that chronicles the evolution over time with summarization of historical perspectives of terminology and to further our understanding regarding their pathogenesis including genomic landscape, clinicoradiological features, pathology, treatment, prognosis, the current status of the management of the primary lesions, their recurrences and metastases. METHODS A comprehensive review of the published English literature was conducted using the search engines PubMed, MEDLINE and GOOGLE scholar. The following search terms [“mixed tumors colon” OR mixed endocrine/neuroendocrine tumor/neoplasm/lesion colon OR adenocarcinoma and endocrine/neuroendocrine tumor colon OR mixed adenocarcinoma and endocrine/neuroendocrine carcinoma colon OR Amphicrine tumors OR Collision tumors] were used. Eligibility criteria were defined and all potential relevant items, including full articles and/or abstracts were independently reviewed, assessed and agreed upon items were selected for in-depth analysis. RESULTS In total 237 full articles/abstracts documents were considered for eligibility of which 45 articles were illegible resulting in a total of 192 articles that were assessed for eligibility of which 139 have been selected for reference in this current review. This seminal manuscript is a one stop article that provides a detailed outlook on the evolution over time with summarization of historical perspectives, nomenclature, clinicoradiological features, pathology, treatment, prognosis and the current status of the management of both the primary lesions, their recurrences and metastases. Gaps in knowledge have also been identified and discussed. An important outcome of this manuscript is the justified prop...

show abstract

Carcinosarcoma of the Rectum: Report of a Rare Colorectal Malignancy and Review of the Literature

Cited by 12 publications

References 14 publications

Abdominotransanal resection of a strangulated rectal carcinosarcoma

Abdominotransanal resection of a strangulated rectal carcinosarcoma

Carcinosarcoma of the colon with extensive and extraordinary metastases detected on F-FDG18PET/CT: A case report

Mixed epithelial endocrine neoplasms of the colon and rectum – An evolution over time: A systematic review

Contact Info

Product

Resources

About