Carcinosarcoma of the Thyroid Gland

Ekici, Mehmet Fati̇h; Koçak, Cengiz; Bayhan, Zülfü; Zeren, Sezgin; Yaylak, Faik; Metineren, Mehmet Hüseyin; Koçak, Fatma Emel

doi:10.1155/2015/494383

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…The results suggest that these tumours are a very aggressive malignancy in dogs. While also rare in humans, the outcomes described here are similar to outcomes in humans with thyroid carcinosarcomas where the survival is typically only a few months (al‐Sobhi et al., 1997 , Yang et al., 2018 , Agrawal et al., 2013 , Ekici et al., 2015 ). In one study of 17 reported humans with thyroid carcinosarcomas, the reported median survival time was 5 months (al‐Sobhi et al., 1997 ).…”

Section: Discussionsupporting

confidence: 71%

Clinical outcomes of thyroid tumours with concurrent epithelial and mesenchymal components in 14 dogs (2006–2020)

Cook

Gaspirini

Cianciolo

et al. 2022

Veterinary Medicine & Sci

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Background While rare, multiple individual case reports have described mixed thyroid tumours in dogs containing both epithelial and mesenchymal neoplastic components. Objectives In this retrospective case series, we describe the clinical presentation, treatment and outcome of 14 dogs of canine thyroid tumours with concurrent mesenchymal and epithelial neoplastic populations. Methods Fourteen cases were retrospectively abstracted from nine institutions. Histopathologic samples and reports were collected from 10/14 dogs and reviewed by a single board‐certified anatomic pathologist. Results All 14 dogs had curative‐intent surgery to remove the thyroid neoplasm. The most common surgery performed was a unilateral thyroidectomy (10/14 dogs). Postoperatively, systemic therapy was administered in eight dogs. Six dogs developed local recurrence with a median time to loco‐regional recurrence of 53 days. Ten dogs developed metastatic disease with the most common metastatic site being the lungs (6/10 dogs), with a median time to metastasis of 93 days. Ten dogs were euthanised due to locoregional or distant progression of their mixed thyroid neoplasm. The overall median survival time was 156 days (95%CI: 49–244). The median survival time for dogs treated with adjuvant therapy was 189 days (95%CI: 24–244), whereas dogs without adjuvant therapy had a median survival time of 156 days (95%CI: 35‐upper limit could not be calculated; p = 0.62). Conclusion The thyroid tumours with both mesenchymal and epithelial components in this small sample set were associated with a poor prognosis after surgical excision with or without adjunctive therapy.

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Section: Discussionsupporting

confidence: 71%

Clinical outcomes of thyroid tumours with concurrent epithelial and mesenchymal components in 14 dogs (2006–2020)

Cook

Gaspirini

Cianciolo

et al. 2022

Veterinary Medicine & Sci

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A rare case of thyroid carcinosarcoma arising from recurrent papillary thyroid cancer: Case report and review of the literature

Gao,

Tang,

Zhang

et al. 2024

Oral Oncology

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A rare malignant thyroid carcinosarcoma with aggressive behavior and DICER1 gene mutation: a case report with literature review

et al. 2018

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BackgroundMalignant biphasic tumor also known as carcinosarcoma is an uncommon neoplasm that is composed of both malignant epithelial and mesenchymal components. Most reported cases of carcinosarcoma affect the female genital tract; however, other sites including head and neck, lung, and breast have been described. Carcinosarcoma of the thyroid is an extremely rare and aggressive malignancy with an ominous clinical course similar to anaplastic carcinoma.Case presentationWe report a case of a 45-year-old female who was found to have a biphasic thyroid carcinosarcoma. Her clinical course declined significantly shortly after she underwent a total thyroidectomy and she developed distant metastases to the lungs. Histopathological features of the primary and metastatic tumor were identical. The tumor is composed of an intimately intermixed epithelial component of poorly differentiated follicular thyroid carcinoma and a spindle cell sarcoma with rhabdomyosarcoma differentiation. Molecular analysis using a next-generation sequencing based assay revealed a DICER1 (E1705K) point mutation in neoplastic cells.ConclusionTo our knowledge, the E1705K point mutation within the DICER1 gene is the first reported mutation in carcinosarcoma of the thyroid. A comprehensive review of the relevant literature is also included for discussion.

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Carcinosarcoma of the Thyroid Gland

Cited by 3 publications

References 3 publications

Clinical outcomes of thyroid tumours with concurrent epithelial and mesenchymal components in 14 dogs (2006–2020)

Clinical outcomes of thyroid tumours with concurrent epithelial and mesenchymal components in 14 dogs (2006–2020)

A rare case of thyroid carcinosarcoma arising from recurrent papillary thyroid cancer: Case report and review of the literature

A rare malignant thyroid carcinosarcoma with aggressive behavior and DICER1 gene mutation: a case report with literature review

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