Cardamom fruits as a green resource for facile synthesis of gold and silver nanoparticles and their biological applications

Abstract

Gold (FA-AuNps) and silver (FA-AgNps) nanoparticles were synthesized at room temperature by aqueous extract of dried fruits of Amomum villosum, also known as Fructus Amomi (cardamom), in order to confer antioxidant, catalytic, antimicrobial activities and treatment effect against breast cancer cells. Fruit extracts served as both reducing agents and stabilizers in lieu of chemical agents. Ultra-violet visible (UV-Vis) spectroscopy, field emission transmission electron microscopy (FE-TEM), energy-dispersive X-ray (EDX) spectroscopy, elemental mapping, X-ray powder diffraction (XRD), selected area electron diffraction (SAED), dynamic light scattering (DLS) and Fourier transform infrared (FTIR) spectroscopy were employed to characterize the biosynthesized nanoparticles. Both FA-AuNps and FA-AgNps exhibited free radical scavenging activity against 2,2-diphenyl-1-picrylhydrzyl (DPPH). Additionally, biosynthesized nanoparticles successfully reduced methylene blue, a well-known redox indicator. FA-AgNps showed zones of inhibition against pathogenic Staphylococcus aureus and Escherichia coli. Finally, the biological activities and cytotoxicity of nanoparticles were subsequently investigated in vitro. FA-AuNps demonstrated a potential cytotoxic agent against breast cancer cells as evaluated by MTT assay. The study highlights a rapid synthesis of FA-AuNps and FA-AgNps by dried Fructus Amomi aqueous extract and evaluates their potential biological applications on medical platforms.

Augmented photocatalytic, antibacterial and antifungal activity of prunosynthetic silver nanoparticles

“…No zone formation (Table 3) for both strains in case of AgNO 3 salt solution exhibits their resistance. BSNPs surpassed the antibiotics tested consistent with biogenic AgNPs expressing potent antimicrobial activity towards different antibiotics [18]. Moreover, pronounced augmentation in ZOI was observed with an increase in BSNPs conc.…”

Therapeutic prospective of plant-induced silver nanoparticles: application as antimicrobial and anticancer agent

“…When the AgNPs were incubated both in pH 7.4 and pH 5 buffers, it was seen that silver ion release was more at acidic pH, confirming the selective killing of cancer cells at lower pH. It is also confirmed that the formation of nanoparticle aggregation can control the cervical cancer cell and non-aggregates can increase the cellular viscosity and disturb the important cellular processes that eventually leads to cellular apoptosis [32]. Anti-angiogenic properties of AgNPs are also illustrated by some researchers.…”

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