Cardiac 123I-MIBG uptake is affected by variable uptake in reference regions

Variations in 123I-metaiodobenzylguanidine (MIBG) late heart mediastinal ratios in chronic heart failure: a need for standardisation and validation

“…At rest, elderly subjects show increased sympathetic and decreased parasympathetic activity as well as impaired arterial baroreflex function [ 24 – 34 ]. The negative correlation, although weak, between age and late H/M is in line with the finding that sympathetic activity increases with age typically reflected by increased circulating catecholamine levels, and that it is associated with decreased myocardial uptake of 123 I-MIBG, an observation previously reported by Somsen et al [ 35 ] and Estorch et al [ 36 ].…”

Normal values and within-subject variability of cardiac I-123 MIBG scintigraphy in healthy individuals: implications for clinical studies

“…Several variables, such as age and body weight, have been shown to be related to cardiac I-123 MIBG uptake and washout. [19][20][21][22] In our study only weight was a consistent independent determinant of various I-123 MIBG SPECT indices in univariate analysis. However, only early cardiac uptake on SPECT images was related to weight in multivariate analysis.…”

How to use myocardial 123I-MIBG scintigraphy in chronic heart failure

“…However, there are limited data on the impact of ROI definition on H/ M ratios and myocardial washout. Somsen et al demonstrated in 25 healthy volunteers that 123 I-MIBG semiquantitative parameters using a ROI of the myocardium including the left ventricle showed the lowest interindividual and within-subject variability [15]. In a large retrospective study a uniform analysis with clear definition of the myocardial ROI (variable in size, including the left ventricular cavity) and the mediastinal ROI (fixed size) showed remarkable consistency in interpretation between three blinded image evaluators ( Fig.…”