Cardiac activity and blood pressure in rats during selective blockade of various subtypes of muscarinic cholinoceptors

Зефиров, Т. Л.; Ziyatdinova, N. I.; Saifutdinova, L. R.; Зефиров, А. Л.

doi:10.1007/s10517-006-0246-5

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…The observed effects of VNS on RSA magnitude may result from (1) activation of brainstem loop via stimulation of afferent fibers (Paintal, 1973; Kubin et al., 2006; Osharina et al., 2006), (2) alteration of vagal afferent tone (Fouad et al., 1984; Pomeranz et al., 1985; Hayano et al., 1991), which modulates specific tonic and phasic parasympathetic efferent fibers (Jones et al., 1998; Golberger et al., 1994; 2001; Hayano & Yasuma, 2003), (3) activation of efferent vagal fibers in the case of partial VNS anodal block (D’Angelo, 1978; Tai & Jiang, 1994; Jones et al., 1995; Vuckovic et al., 2005) resulting in disturbance or abolition of physiologic efferent phasic and tonic firing (Guz et al., 1964; Banzett et al., 1999; Zefirov et al., 2006) or additive excitatory input to the heart, or (4) a combination of both efferent and afferent vagal fiber stimulation. In addition, changes in respiration due to VNS could also modify RSA.…”

Section: Discussionmentioning

confidence: 99%

Vagus nerve stimulation induces changes in respiratory sinus arrhythmia of epileptic children during sleep

Zaaimi¹,

Grebe²,

Berquin³

et al. 2009

Epilepsia

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SUMMARYPurpose: This study analyzed the direct shortterm effect of vagus nerve stimulation (VNS) on respiratory sinus arrhythmia (RSA) in children with pharmacoresistant epilepsy. Methods: RSA magnitude is calculated as the ratio between maximum and minimum heart rate for each respiratory cycle-before, during, and after the actual VNS period. In 10 children, changes in RSA magnitude were evaluated on polysomnographic recordings, including electrocardiography (ECG), electroencephalography (EEG), thoracoabdominal distension, nasal airflow, and VNS artifacts. Measurements during stimulation were compared with those at baseline, immediately preceding the VNS periods and individually for each patient. Result: During VNS, respiratory frequency increased and respiratory amplitude decreased with a variable effect on cardiac activity. The coupling between heart rate and respiratory rate was disturbed and RSA magnitude decreased significantly in 6 of 10 children during VNS. These changes in RSA magnitude varied from one child to another. The observed changes for respiratory and cardiac activity were concomitant with changes in RSA but were not correlated. Conclusion: Together with disorders of respiration, cardiac activity, and oxygen saturation (SaO 2 ) described previously. VNS also modifies synchronization between cardiac and respiratory activity, resulting in poor optimization of oxygen delivery to tissues that can be regarded as an additive side effect, which should be considered in patients with already altered brain function. This interaction between the effects of VNS and potential autonomic nervous system (ANS) dysfunction already reported in epileptic patients should be considered to be potentially life-threatening. In addition, evaluation of changes in respiratory parameters can also provide reliable markers for further evaluation of the effectiveness of VNS.

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Section: Discussionmentioning

confidence: 99%

Vagus nerve stimulation induces changes in respiratory sinus arrhythmia of epileptic children during sleep

Zaaimi¹,

Grebe²,

Berquin³

et al. 2009

Epilepsia

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“…Their influences are realized via interaction with adrenoceptors and muscarinic cholinergic receptors (M-ChR) on cardiac cells [1,8,10]. There are at least 9 subtypes of adrenoceptors and 5 subtypes of M-ChR.…”

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confidence: 99%

M3 cholinergic receptors are involved in postnatal development of cholinergic regulation of cardiac activity in rats

Зефиров¹,

Gibina²,

Salman³

et al. 2007

Bull Exp Biol Med

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We studied the role of M3 cholinergic receptors in the regulation of cardiac activity in rats during early postnatal ontogeny in vivo. Blockade of M3 cholinergic receptors in 20-week-old animals increased heart rate and decreased blood pressure. In rats aging 8, 6, and 3 weeks, blockade of M3 cholinergic receptors had little effect on R-R interval, but unexpectedly increased it in 1-week-old animals. It can be hypothesized that tonic inhibitory effect of the vagus nerve in adult rats is realized through M3 cholinergic receptors of the heart. The decrease in heart rate during blockade of M3 cholinergic receptors in 1-week-old rats was probably related to specific innervation of the heart in animals of this age.

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Effect of Selective Stimulation of Muscarinic M3 Cholinoceptors on Electrical and Contractile Activity of Rat Ventricular Myocardium

Abramochkin

Tapilina

Sukhova³

2013

Bull Exp Biol Med

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We studied the effect of selective activation of muscarinic M3receptors on electrical activity in the isolated preparation of rat ventricular myocardium as well as contractile activity of the left ventricle of Langendorff-perfused isolated heart. Application of muscarinic agonist pilocarpine (10(-5)M) against the background of selective blockade of subtype 2 muscarinic receptors with methoctramine (10(-7)M) markedly shortened the duration of action potentials in the isolated ventricular myocardium and reduced the amplitude and maximum rates of left-ventricular pressure rise and decay in the isolated heart paced at a fixed rate. All these effects were significantly suppressed by selective M3receptor blocker 4-DAMP (10(-8)M), which attested to the involvement of M3muscarinic receptors.

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Cardiac activity and blood pressure in rats during selective blockade of various subtypes of muscarinic cholinoceptors

Cited by 5 publications

References 10 publications

Vagus nerve stimulation induces changes in respiratory sinus arrhythmia of epileptic children during sleep

Vagus nerve stimulation induces changes in respiratory sinus arrhythmia of epileptic children during sleep

M3 cholinergic receptors are involved in postnatal development of cholinergic regulation of cardiac activity in rats

Effect of Selective Stimulation of Muscarinic M3 Cholinoceptors on Electrical and Contractile Activity of Rat Ventricular Myocardium

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