Cardiac and Vascular Causes of Syncope and Atherosclerosis

Silva, Rose Mary Ferreira Lisboa da; Brugada, Josép

doi:10.1007/s11886-022-01757-7

Cited by 4 publications

(4 citation statements)

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“…Atherosclerosis is a chronic inflammatory disease that affects primarily the vascular intima, thus leading to a greater c-IMT and the formation of plaques. Atherosclerotic plaques constitute a pathophysiological element of arrhythmias, and are cardiac or vascular structural impairments that cause CS [20]. Risk factors for cardiovascular and metabolic diseases contribute to atherosclerotic damage and related complications, thus resulting in the manifestation of the clinical presentation observed in CS [21,22].…”

Section: Discussionmentioning

confidence: 99%

An Investigation of Metabolic Risk Factors and Gut Microbiota in Unexplained Syncope

Longo,

Del Chierico,

Scanu

et al. 2024

Biomedicines

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Background: The pathogenesis of many syncopal episodes remains unexplained. Intestinal dysbiosis could be involved in the pathophysiological mechanisms of syncope due to its connection with the central nervous system via the microbiota–gut–brain axis. This pilot study aimed to explore the specific cardiometabolic risk factors and gut microbiota in unexplained syncope (US), compared to other types of syncope, to assess their similarity or verify their different origins. Methods: We studied 86 participants with syncope, who were divided into four groups: an orthostatic syncope group (OH, n = 24), a neuromediated syncope group (NMS, n = 26), a cardiological syncope group (CS, n = 9), and an unexplained syncope group (US, n = 27). We evaluated the anthropometric, clinical, and metabolic characteristics of the four groups; the α- and β-diversity; and the differences in the abundance of the microbial taxa. Results: The US group had a lower incidence of systolic hypertension at the first visit and a lower frequency of patients with nocturnal hypertension than the CS group. Compared to the OH and NMS groups, the US group had a higher incidence of carotid plaques and greater carotid intima–media thickness, respectively. The microbiota differed significantly between the US and CS groups, but not between the US group and the OH or NMS group. Conclusions: We observed significant differences in the gut microbiota between CS and US. Future studies are necessary to evaluate the involvement of the gut microbiota in the complex pathogenesis of syncope and whether its analysis could support the interpretation of the pathophysiological mechasnisms underlying some episodes classifiable as US.

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Section: Discussionmentioning

confidence: 99%

An Investigation of Metabolic Risk Factors and Gut Microbiota in Unexplained Syncope

Longo,

Del Chierico,

Scanu

et al. 2024

Biomedicines

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“…Die rhythmogenen Ursachen umfassen bradykarde (z. B. Sick-Sinus-Syndrom oder ein höhergradiger AV-Block) sowie tachykarde ventrikuläre oder seltener supraventriku-läre Herzrhythmusstörungen [8]. Zu den ursächlichen strukturellen Herzerkrankungen gehören die Aortenklappenstenose und der akute Myokardinfarkt, aber auch seltenere Krankheitsbilder wie das Vorhofmyxom oder die hypertrophe obstruktive Kardiomyopathie [1,8].…”

Section: Kardiale Synkopeunclassified

“…B. Sick-Sinus-Syndrom oder ein höhergradiger AV-Block) sowie tachykarde ventrikuläre oder seltener supraventriku-läre Herzrhythmusstörungen [8]. Zu den ursächlichen strukturellen Herzerkrankungen gehören die Aortenklappenstenose und der akute Myokardinfarkt, aber auch seltenere Krankheitsbilder wie das Vorhofmyxom oder die hypertrophe obstruktive Kardiomyopathie [1,8]. Darüber hinaus werden Synkopen, die im Rahmen einer Lungenarterienembolie oder einer akuten Aortendissektion auftreten, unter dem Begriff der kardialen Synkope subsummiert [1,8].…”

Section: Kardiale Synkopeunclassified

“…Zusätzlich werden häufig weitere Symptome, wie Dyspnoe, Angina pectoris, Schwindel oder Palpitationen, unabhängig von der Synkope beschrieben. Auch das Fehlen unmittelbarer Prodromi sollte an eine kardiale Genese denken lassen [1,8]. Ebenso durch einen TLOC gekennzeichnet ist der psychogene Bewusstseinsverlust (auch als psychogene Pseudosynkope bezeichnet).…”

Section: Merkeunclassified

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