Cardiac Angiosarcoma on the Right Atrium: Two Cases

Park, Won Kyoun; Jung, Sung‐Ho; Lim, Ju Yong

doi:10.5090/kjtcs.2012.45.2.120

Cited by 9 publications

(6 citation statements)

References 5 publications

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“…[ 20 ] Although, this case responds poorly to chemotherapy and targeted therapy, some of limited cases, after radical resection, a multidisciplinary approach with adjuvant chemotherapy, radiotherapy, and targeted therapy may improve overall survival even reaching 33 months. [ 21 – 23 ]…”

Section: Discussionmentioning

confidence: 99%

Primary cardiac angiosarcoma

Zhang¹,

Lu²,

Li³

et al. 2017

Medicine

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Background:Primary cardiac angiosarcoma is rare, but it is the most aggressive type of cardiac malignant tumor. When disease is confirmed it is often late in its stage resulting in a poor prognosis.Case presentation:We reported a 52-year-old woman who complained of dyspnea for 2 months and dry cough for 10 days. Computed tomography (CT), 18F-fluorodeoxyglucose (18F-FDG), positron emission tomography-computed tomography (PET-CT), and transthoracic echocardiography showed a space-occupying lesion 7 cm × 5 cm × 5 cm in the right atrium. Malignant cells can be seen in pericardial fluid by pericardiocentesis in local hospital, but not be diagnosed definitely. We conducted CT-guided biopsy of the tumor and observed the necrotic tissues. An exploratory thoracotomy was performed and histological examination confirmed angiosarcoma. Unable to be surgical excision due to infiltrating widely, the patients received chemotherapy with docetaxel for 2 cycles and the disease was progressive. Antiangiogenesis-targeted therapy was combined with chemotherapy for 3 months. Unfortunately, the tumor was still in progress. She died of respiratory failure, survived for 10 months.Conclusion:It is difficult to diagnose the primary cardiac angiosarcoma in early stage. Chemotherapy and target therapy are very limited in this case. Surgery remains the preferred treatment for patients with primary cardiac angiosarcoma. More efforts should be carried out on the effective diagnosis and multimodality treatment for this malignant disease.

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Section: Discussionmentioning

confidence: 99%

Primary cardiac angiosarcoma

Zhang¹,

Lu²,

Li³

et al. 2017

Medicine

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“…[6] Complete removal of the tumor and cardiac reconstruction may be the only solution to offer those patients symptomatic relief and improved quality of life. [7] Management should mainly encompass chemotherapy and radiotherapy, as metastatic involvement is frequent at the time of presentation. [8] Complete or palliative resection with adjuvant therapy improves the quality of life and may increase the length of survival for less than a year.…”

Section: Discussionmentioning

confidence: 99%

Resection of a giant right atrial angiosarcoma invading the atrioventricular groove

Alassal¹

2016

Turk Gogus Kalp Dama

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Kardiyak anjiyosarkomlar, kalbin en sık görülen primer malign tümörleridir. Genellikle uzun bir süre asemptomatik seyrettikten sonra, nonspesifik semptomlar ile aniden ortaya çıkar. Sıklıkla tanı esnasında, cerrahi rezeksiyon endikasyonunu hastaların küçük bir kısmı ile sınırlayan metastazlar bulunur. Bu yazıda, başarılı bir şekilde tümörün cerrahi olarak rezeke edildiği ve sağ atriyumun sığır perikard yaması ile rekonstrüksiyonunun yapıldığı, metastatik olmayan dev primer sağ atriyal anjiyosarkomlu 28 yaşında erkek bir olgu sunuldu. Anah tar söz cük ler: Anjiyosarkom; kalp tümörleri; tıkanma sendromu; superior/inferior vena kava.

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“…Several studies reported survival times ranging from 12 to 30 months with the use of various combinations of surgery, chemotherapy, radiation and/or transplant in cases of locally advanced or metastatic disease [ 8 ]. In case of limited disease, after radical resection, a multidisciplinary approach with adjuvant chemotherapy and radiotherapy may improve overall survival [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of weekly docetaxel in locally advanced cardiac angiosarcoma

et al. 2015

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BackgroundPrimary cardiac angiosarcoma is extremely aggressive; however, it is often misdiagnosed because of its rarity. For locally advanced tumors, doxorubicin-based chemotherapy regimens are the standard of treatment, even if the gain in term of progression-free survival is limited and is no longer than 5 months.Case presentationWe report the case of a Caucasian 23-year-old man with locally advanced cardiac angiosarcoma who underwent radical surgical resection after a prolonged response to weekly docetaxel and complementary radiotherapy.ConclusionCombined treatment with weekly docetaxel and radiotherapy may be a valid alternative for the treatment of locally advanced cardiac angiosarcoma; the combination can lead to radical surgical resections, avoiding the cumulative cardiotoxicity of antracycline-based regimens.

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Cardiac Angiosarcoma on the Right Atrium: Two Cases

Cited by 9 publications

References 5 publications

Primary cardiac angiosarcoma

Primary cardiac angiosarcoma

Resection of a giant right atrial angiosarcoma invading the atrioventricular groove

Efficacy of weekly docetaxel in locally advanced cardiac angiosarcoma

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