Cardiac angiotensin receptors in experimental hyperthyroidism in dogs

Sernia, Conrad; Marchant, Catherine; Brown, Lindsay; Hoey, Andrew

doi:10.1093/cvr/27.3.423

Cited by 38 publications

(29 citation statements)

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“…These data indicate that factors other than hemodynamic changes play an important role in the pathogenesis of T 4 -induced cardiac hypertrophy [30,31], and clinical evidence suggests that blocking the actions of angiotensin II might confer protective benefits beyond lowering BP [32]. Although there is controversy regarding the formation of myocardial fibrosis induced by TH [33][34][35], considering that RAS is activated in patients with hyperthyroidism [16,17] and myocardial fibrosis depends on a complex relationship between stimulatory (including angiotensin II, endothelin I, catecholamines and aldosterone) and inhibitory factors acting on the collagen production [36], it is reasonable to suggest that these mechanisms could mediate the increased myocardial fibrosis observed in our experimental data, suggesting the involvement of TH in regulating myocardial fibrosis. Interestingly, treatment with RAS inhibitor was presently able to prevent myocardial fibrosis.…”

Section: Hyperthyroidism and Cardiac Functionmentioning

confidence: 97%

“…However, there are also conflicting reports regarding the preventative nature of sympathetic inhibition in TH-induced cardiac hypertrophy [12,13]. TH directly stimulates renin mRNA in vivo [13,14] and in vitro [15], and increases both the synthesis and secretion of angiotensinogen and angiotensin (ANG) II receptors [16]. Also, TH activates circulating and tissue RAS without involving the SNS, and this may account for the cardiac hypertrophy observed in hyperthyroidism [14,17].…”

Section: Echocardiographymentioning

confidence: 99%

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Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy

et al. 2012

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Section: Hyperthyroidism and Cardiac Functionmentioning

confidence: 97%

Section: Echocardiographymentioning

confidence: 99%

Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy

et al. 2012

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“…T3 also increased angiotensinogen production from liver in rats 84) . However, another report failed to detect any changes in the angiotensinogen level in the hyperthyroid dog 85) . The differential results may be ascribed to the difference of species or duration and dosages of T3 treatment.…”

Section: Thyroid Hormone and Angiogenesismentioning

confidence: 94%

“…The differential results may be ascribed to the difference of species or duration and dosages of T3 treatment. Interestingly, both studies reported an increase in plasma angiotensin II levels 84,85) , suggesting that the systemic RAS is eventually activated in hyperthyroidism regardless of angiotensinogen levels.…”

Section: Thyroid Hormone and Angiogenesismentioning

confidence: 96%

Thyroid Hormone and Vascular Remodeling

Ichiki

2016

JAT

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Both hyperthyroidism and hypothyroidism affect the cardiovascular system. Hypothyroidism is known to be associated with enhanced atherosclerosis and ischemic heart diseases. The accelerated atherosclerosis in the hypothyroid state has been traditionally ascribed to atherogenic lipid profile, diastolic hypertension, and impaired endothelial function. However, recent studies indicate that thyroid hormone has direct anti-atherosclerotic effects, such as production of nitric oxide and suppression of smooth muscle cell proliferation. These data suggest that thyroid hormone inhibits atherogenesis through direct effects on the vasculature as well as modification of risk factors for atherosclerosis. This review summarizes the basic and clinical studies on the role of thyroid hormone in vascular remodeling. The possible application of thyroid hormone mimetics to the therapy of hypercholesterolemia and atherosclerosis is also discussed.

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“…While TH indirectly modifies atherosclerotic risk factors such as lipid profile (2,3) and blood pressure (4), direct effects act via vascular smooth muscle cells, altering vascular tone (5), angiotensin-II type 1 receptor modulating the proliferation of vascular smooth muscle cells (6), upregulation of basic fibroblast growth factor causing enhanced angiogenesis (7), modulating the maturation and functioning of macrophages (8), and acting on the renin-angiotensin system (9,10). However, clinical studies yield conflicting results and mechanistic explanations remain elusive (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Impact of free thyroxine levels and other clinical factors on bare metal stent restenosis

Canpolat

Turak

Özcan

et al. 2017

Arch. Endocrinol. Metab.

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Objective: Thyroid hormones have both direct and indirect effects on thermogenesis such as modulating vascular smooth muscle cell proliferation. However, the influence of more subtle changes in thyroid hormones on coronary atherosclerosis remains a matter of speculation. Smooth muscle cells play a crucial role in the pathogenesis of in-stent restenosis (ISR). However, the relationship between free thyroxine (fT4) and ISR has not been studied. In the present study, we aimed to assess the role of preprocedural serum fT4 level on the development of ISR in patients undergoing coronary bare metal stent (BMS) implantation. Materials and methods: We enrolled and analyzed clinical, biochemical, and angiographic data from 705 consecutive patients without a history of primary thyroid disease [mean age 60.3 ± 9.3 years, 505 (72%) male]; all patients had undergone BMS implantation and further control coronary angiography owing to stable or unstable angina pectoris. Patients were divided into 3 tertiles based on preprocedural serum fT4 levels. Results: ISR was observed in 53 (23%) patients in the lowest tertile, 82 (35%) patients in the second tertile, and 107 (46%) patients in the highest fT4 tertile (p < 0.001). Using multiple logistic regression analysis, five characteristics emerged as independent predictors of ISR: diabetes mellitus, smoking, HDL-cholesterol, stent length, and preprocedural serum fT4 level. In receiver operating characteristics curve analysis, fT4 level > 1.23 mg/dL had 70% sensitivity and 73% specificity (AUC: 0.75, p < 0.001) in predicting ISR. Conclusion: Higher preprocedural serum fT4 is a powerful and independent predictor of BMS restenosis in patients with stable and unstable angina pectoris. Arch Endocrinol Metab. 2017;61(2):130-6.

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Cardiac angiotensin receptors in experimental hyperthyroidism in dogs

Abstract: Experimental hyperthyroidism in dogs results in activation of the plasma renin-angiotensin system and up regulation of left ventricular, aortic, and liver angiotensin II receptors.

Cited by 38 publications

References 0 publications

Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy

Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy

Thyroid Hormone and Vascular Remodeling

Impact of free thyroxine levels and other clinical factors on bare metal stent restenosis

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