Cardiac Applications of 123I-mIBG Imaging

Chirumamilla, Amala; Travin, Mark I.

doi:10.1053/j.semnuclmed.2011.04.001

Cited by 69 publications

(58 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…15 Heart failure presents high mortality rates, and around 50% of deaths are related to sudden death. 16 In 2014, only in Brazil, more than 26,000 deaths were related to HF, and approximately half of them occurred in the southeast of the country.…”

Section: Use Of 123 I-mibg Scintigraphy In Chfmentioning

confidence: 99%

The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!

Rocha¹,

Alves²,

Verschure³

et al. 2017

International Journal of Cardiovascular Sciences

View full text Add to dashboard Cite

show abstract

Section: Use Of 123 I-mibg Scintigraphy In Chfmentioning

confidence: 99%

The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!

Rocha¹,

Alves²,

Verschure³

et al. 2017

International Journal of Cardiovascular Sciences

View full text Add to dashboard Cite

show abstract

“…The 99m Tc-labelled radiopharmaceuticals sestamibi (MIBI) and tetrofosmin are commonly used for myocardial perfusion imaging (Baggish and Boucher 2008). The 123 I-labelled agents metaiodobenzylguanidine (MIBG) and iodophenylpentadecanoic acid (IPPA) can be used to image myocardial sympathetic innervation and fatty acid metabolism respectively (Verani et al 2000, Chirumamilla andTravin 2011). The use of combinations of these or other 99m Tc-and 123 I-labelled agents can be advantageous as differences in uptake can assist in patient diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Model-based correction for scatter and tailing effects in simultaneous^99mTc and¹²³I imaging for a CdZnTe cardiac SPECT camera

et al. 2015

View full text Add to dashboard Cite

. (2015). Model-based correction for scatter and tailing effects in simultaneous 99mTc and 123I imaging for a CdZnTe cardiac SPECT camera. Physics in Medicine and Biology, 60 (8), 3045-3063. Model-based correction for scatter and tailing effects in simultaneous 99mTc and 123I imaging for a CdZnTe cardiac SPECT camera Abstract 2015 Institute of Physics and Engineering in Medicine. An advantage of semiconductor-based dedicated cardiac single photon emission computed tomography (SPECT) cameras when compared to conventional Anger cameras is superior energy resolution. This provides the potential for improved separation of the photopeaks in dual radionuclide imaging, such as combined use of 99m Tc and 123 I . There is, however, the added complexity of tailing effects in the detectors that must be accounted for. In this paper we present a model-based correction algorithm which extracts the useful primary counts of 99m Tc and 123 I from projection data. Equations describing the in-patient scatter and tailing effects in the detectors are iteratively solved for both radionuclides simultaneously using a maximum a posteriori probability algorithm with one-step-late evaluation. Energy window-dependent parameters for the equations describing in-patient scatter are estimated using Monte Carlo simulations. Parameters for the equations describing tailing effects are estimated using virtually scatter-free experimental measurements on a dedicated cardiac SPECT camera with CdZnTedetectors. When applied to a phantom study with both 99m Tc and 123 I, results show that the estimated spatial distribution of events from 99m Tc in the 99m Tc photopeak energy window is very similar to that measured in a single 99m Tc phantom study. The extracted images of primary events display increased cold lesion contrasts for both 99m Tc and 123 I. AbstractAn advantage of semiconductor-based dedicated cardiac single photon emission computed tomography (SPECT) cameras when compared to conventional Anger cameras is superior energy resolution. This provides the potential for improved separation of the photopeaks in dual radionuclide imaging, such as combined use of 99m Tc and 123 I . There is, however, the added complexity of tailing effects in the detectors that must be accounted for. In this paper we present a model-based correction algorithm which extracts the useful primary counts of 99m Tc and 123 I from projection data. Equations describing the in-patient scatter and tailing effects in the detectors are iteratively solved for both radionuclides simultaneously using a maximum a posteriori probability algorithm with one-step-late evaluation. Energy window-dependent parameters for the equations describing in-patient scatter are estimated using Monte Carlo simulations. Parameters for the equations describing tailing effects are estimated using virtually scatter-free experimental measurements on a dedicated cardiac SPECT camera with CdZnTe-detectors. When applied to a phantom study with both 99m Tc and 123 I, results show that the estimated spatia...

show abstract

“…In the setting of disease, autonomic control is often disrupted, with resultant image abnormalities that are both a reflection of disease severity and a prediction of further clinical deterioration. 15 There is accumulating evidence that imaging with autonomic radiotracers can evaluate patients with a wide variety of cardiac conditions, including heart failure (HF), arrhythmias, and ischemic heart disease, providing highly effective risk stratification and therefore a potential guide for improving patient management.…”

Section: Introductionmentioning

confidence: 99%

Cardiac autonomic imaging with SPECT tracers

Travin

2013

Journal of Nuclear Cardiology

Self Cite

View full text Add to dashboard Cite

Cardiac Applications of 123I-mIBG Imaging

Cited by 69 publications

References 82 publications

The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!

The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!

Model-based correction for scatter and tailing effects in simultaneous^99mTc and¹²³I imaging for a CdZnTe cardiac SPECT camera

Cardiac autonomic imaging with SPECT tracers

Contact Info

Product

Resources

About

Cardiac Applications of 123I-mIBG Imaging

Cited by 69 publications

References 82 publications

The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!

The use of Cardiac 123I-mIBG Scintigraphy in Clinical Practice: The Necessity to Standardize!

Model-based correction for scatter and tailing effects in simultaneous99mTc and123I imaging for a CdZnTe cardiac SPECT camera

Cardiac autonomic imaging with SPECT tracers

Contact Info

Product

Resources

About

Model-based correction for scatter and tailing effects in simultaneous^99mTc and¹²³I imaging for a CdZnTe cardiac SPECT camera