Cardiac Arrest following Haemaccel

Duffy, Brian L.; Harding, J.; Fuller, W. R.; Peake, Sandra

doi:10.1177/0310057x9402200116

Cited by 23 publications

(6 citation statements)

References 16 publications

(7 reference statements)

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“…Although a reaction to gelatin is generally believed to be due to histamine release, Duffy et al . reported cardiac arrest in a patient following Haemaccel ® and demonstrated an immunological basis for this [3]. Fisher and Baldo reported that in 3% of anaphylactic reactions, bronchospasm may be the only presenting feature and is inevitable in patients with pre‐existing asthma [6]; our patient showed no cutaneous or haemodynamic manifestations.…”

mentioning

confidence: 53%

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Severe life threatening reaction to HaemaccelR in a patient with bronchial asthma

Kathirvel¹,

Podder²,

Batra³

et al. 2001

Eur J Anaesthesiol

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mentioning

confidence: 53%

“…Since 1979, polygeline has undergone an improved manufacturing process to reduce the amount of this agent [1]. However, life‐threatening reactions have been reported even with the use of modified gelatin products [2–4]. We report another reaction to Haemaccel ® (Hoechst Pharmaceuticals Ltd, Mumbai, India) in a patient with bronchial asthma.…”

mentioning

confidence: 99%

Severe life threatening reaction to HaemaccelR in a patient with bronchial asthma

Kathirvel¹,

Podder²,

Batra³

et al. 2001

Eur J Anaesthesiol

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“…It is important to quantify the severity of anaphylactoid reactions to colloids, as most reactions are minor, though severe life threatening reactions may occur 40 (see Table 3).…”

Section: Complications Of Fluid Resuscitationmentioning

confidence: 99%

The role of colloids in resuscitation

Vinen

1996

Emergency Medicine

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Colloids have been used for many years in resuscitation yet few studies have thoroughly examined their usefulness. Colloids and a combination of crystalloids and colloids continue to be used without any real scientific basis. Scrutiny of review articles, experimental studies, and clinical investigations reveals conflicting and confusing data. There are too many variables to accurately interpret findings, cross species problems with animal studies, different fluids used making comparisons difficult if not impossible, and confounding variables that include: Health status of the patients Severity/type of injury Complications (especially sepsis) Varying grades of shock Variable time scale of administration of fluids Variable volumes administered Differing methods of determining fluid volume depletion Inconsistent monitoring Differing endpoints Different techniques to measure endpoints Comparison of delayed treatment of traumatic shock with blood loss occurring during surgery of questionable validity. One of the areas that has been studied reasonably well is the allergic effects associated with colloid use and more recently the adverse effects associated with the use of dextrose solutions in patients with head injuries. The continued effort to develop satisfactory resuscitation solutions including the recent development of hypertonic saline solutions (usually in combination with a colloid) highlights the uncertainty that exists in relation to the true role of the colloid and crystalloid agents available. Recent studies question the use of fluids to resuscitate patients with penetrating torso injuries. The aim of this paper is to review what is known about the use of colloids and crystalloids in resuscitation and to recommend guidelines as to which fluid should be used in differing clinical situations.

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“… Should some glucose be used in IV preloads? If so, would it reduce the incidence of hypotension? Does premedication with ranitidine and ephedrine reduce the incidence of adverse reactions to Haemaccel 4,5 ? Is the observed low incidence of adverse reactions to Haemaccel an acceptable risk compared with the risk of severe hypotension and maternal collapse and possible fetal asphyxia 6,7,8 ? Should this method be used in cases of fetal distress, where there is clear evidence of extant fetal asphyxia? Does this method significantly reduce fetal/neonatal lung water in term and pre‐term neonates? …”

Section: Acute Hydration (Pre‐loading)mentioning

confidence: 99%

“…Is the observed low incidence of adverse reactions to Haemaccel an acceptable risk compared with the risk of severe hypotension and maternal collapse and possible fetal asphyxia 6,7,8 ?…”

Section: Acute Hydration (Pre‐loading)mentioning

confidence: 99%

Intravenous fluid administration in pregnancy: maintenance and acute hydration

Crowhurst

1996

Emergency Medicine

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Pregnancy is characterised by a hyperdynamic output state, low blood viscosity and haematocrit, reduced blood and tissue buffering capacity, increased tendency to both sodium and water retention, an exaggerated ketotic and hypoglycaemic response to dehydration and increased insensible losses and decreased heat tolerance. These changes are relevant to anaesthetists attempting to restore and maintain fluid, electrolyte, glucose and metabolic balance in labour and during anaesthesia, resuscitation and critical care. Fluid maintenance and replacement in pregnancy follow the basic principle of replacing what is lost in both quantity and quality, remembering the specific requirements of the individual patient and situation. The altered milieu of pregnancy makes the use of most crystalloid containing fluids somewhat controversial particularly for acute hydration (fluid loading) in association with central neural blockage or resuscitation. Normal saline and lactate tend to worsen reduced buffer base capacity and cause further dilution of plasma proteins in an already low blood glucose level, so potentiating the efforts of highlevel epidural or spinal sympathetic blockade. Glucose loads can cause fetal hyperinsulinaemia, rapid‐onset neonatal hypoglycaemia and jaundice. A balanced approach of fluid administration using colloids, crystalloids and vasopressors will be discussed.

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Cardiac Arrest following Haemaccel

Cited by 23 publications

References 16 publications

Severe life threatening reaction to HaemaccelR in a patient with bronchial asthma

Severe life threatening reaction to HaemaccelR in a patient with bronchial asthma

The role of colloids in resuscitation

Intravenous fluid administration in pregnancy: maintenance and acute hydration

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