Cardiac Arrhythmias in Patients with COVID-19: A Systematic review and Meta-analysis

Hamam, Omar; Goda, Ahmed E.; Eldalal, M; Ussama, Amr; Fahmy, Mostafa Mahmoud; K, Elyamany; Ikram, Waleed; Mahdy, Ahmed El; Bhandari, Renu; Elbahnasawy, Mohammad; Asal, Hosam; Egbe, Alexander C.

doi:10.1101/2020.10.09.20209379

Cited by 6 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two reviews rated moderate quality examined the incidence of arrhythmia developed during hospitalization with COVID-19. 29 , 42 The larger of these reported incidence of arrhythmias as 18.4% (95% CI 7.8–32.3%). 42 One moderate quality review of four studies (245 patients) estimated the incidence of acute cardiac failure with COVID-19 as 6.5% (2.2%–12.2%), considerable heterogeneity ( I 2 = 78%).…”

Section: Resultsmentioning

confidence: 93%

Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews

Harrison

Buckley

Rivera‐Caravaca

et al. 2021

European Heart Journal - Quality of Care and Clinical Outcomes

104

View full text Add to dashboard Cite

Aims To consolidate evidence to determine (i) the association between cardiovascular risk factors and health outcomes with coronavirus 2019 (COVID-19); and (ii) the impact of COVID-19 on cardiovascular health. Methods and results An umbrella review of systematic reviews was conducted. Fourteen medical databases and pre-print servers were searched from 1 January 2020 to 5 November 2020. The review focused on reviews rated as moderate or high-quality using the AMSTAR 2 tool. Eighty-four reviews were identified; 31 reviews were assessed as moderate quality and one was high-quality. The following risk factors were associated with higher mortality and severe COVID-19: renal disease [odds ratio (OR) (95% confidence interval) for mortality 3.07 (2.43–3.88)], diabetes mellitus [OR 2.09 (1.80–2.42)], hypertension [OR 2.50 (2.02–3.11)], smoking history [risk ratio (RR) 1.26 (1.20–1.32)], cerebrovascular disease [RR 2.75 (1.54–4.89)], and cardiovascular disease [OR 2.65 (1.86–3.78)]. Liver disease was associated with higher odds of mortality [OR 2.81 (1.31–6.01)], but not severe COVID-19. Current smoking was associated with a higher risk of severe COVID-19 [RR 1.80 (1.14–2.85)], but not mortality. Obesity associated with higher odds of mortality [OR 2.18 (1.10–4.34)], but there was an absence of evidence for severe COVID-19. In patients hospitalized with COVID-19, the following incident cardiovascular complications were identified: acute heart failure (2%), myocardial infarction (4%), deep vein thrombosis (7%), myocardial injury (10%), angina (10%), arrhythmias (18%), pulmonary embolism (19%), and venous thromboembolism (25%). Conclusion Many of the risk factors identified as associated with adverse outcomes with COVID-19 are potentially modifiable. Primary and secondary prevention strategies that target cardiovascular risk factors may improve outcomes for people following COVID-19.

show abstract

Section: Resultsmentioning

confidence: 93%

Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews

Harrison

Buckley

Rivera‐Caravaca

et al. 2021

European Heart Journal - Quality of Care and Clinical Outcomes

104

View full text Add to dashboard Cite

show abstract

“…HCQ and CQ are traditional antimalarial and autoimmune disease drugs that have been shown to control the SARS-CoV-2 infection in vitro [ 93 ], although the cardiotoxicity of HCQ and CQ should not be neglected. Several systematic reviews included in our study showed an association between these drugs and an increase in serious ventricular arrhythmia [ 21 22 29 ]. Since these reviews have been published, several randomized controlled trials have been performed.…”

Section: Discussionmentioning

confidence: 92%

“…Incidence of arrythmias ranged from 1.8% to 26% in hospitalized COVID-19 patients [ 21 22 23 24 25 26 27 28 29 ], while an incidence of 33% to 48% was reported in severe disease [ 21 25 26 29 30 ]. Newly occurring arrhythmias in COVID-19 patients predicted severe disease and/or mortality [ 21 25 30 31 32 33 34 ].…”

Section: Resultsmentioning

confidence: 99%

Cardiac Manifestations in Patients with COVID-19: A Scoping Review

et al. 2022

View full text Add to dashboard Cite

Background: Coronavirus disease 2019 , commonly affects the lungs, but the involvement of other organs, particularly the heart, is highly prevalent as has been reported in several studies. The overall aim of this review was to provide an in-depth description of the available literature related to the cardiac system and COVID-19 infection. It focuses on type and the frequency of cardiac manifestations, clinical parameters and cardiac biomarkers that support the prognosis of COVID-19 patients, and the cardiac adverse events and outcomes related to pharmacotherapy.Methods: A scoping review was conducted searching Embase, PubMed, Epistomonikos, Medrxiv, BioRxiv databases, up to November 2020, for systematic reviews relevant to cardiac manifestations in adult COVID-19 patients. Relevant articles were screened and extracted to summarize key outcomes and findings.Results: A total of 63 systematic reviews met the inclusion criteria. The overall frequency of acute cardiac injury ranged from 15% to 33% in the reporting studies. The main cardiac complications were arrhythmias (3.1% to 6.9% in non-severe patients, 33.0% to 48.0% in severe disease), acute coronary syndromes (6% to 33% in severe disease), and myocarditis. Most studies found no association with the use of Reninangiotensin-aldosterone system inhibitors (RAASI) with COVID-19 outcomes such as susceptibility to infection, hospitalization, severity, and mortality. Conclusion:This study provided an overview of the several cardiac complications associated with Covid-19. Cardiac injury, arrhythmias, myocarditis, cardiac failure, and acute coronary syndrome, are prevalent and clinically significant and associated with COVID-19 disease severity and mortality. Other studies are needed to clearly identify what is the part of viral heart infection and what is the part of cardiac injury secondary to acute respiratory failure and inflammation. In the therapeutic field, these systematic reviews gave heterogenous results. This underlines the importance of randomized trials to determine the right therapeutic approach. 2 Peiris et al.

show abstract

“…El 56,6% de los pacientes hospitalizados con CO-VID-19 en nuestro estudio presentaron alteraciones electrocardiográficas; comparado con otros trabajos consultados, la proporción fue ligeramente superior [12][13][14] . Pese a ello, cuando se analizaron pacientes graves ingresados en unidades de cuidados intensivos los resultados de nuestro estudio fueron similares e incluso ligeramente inferiores 15,16 .…”

Section: Resultsunclassified

Alteraciones electrocardiográficas en pacientes hospitalizados con COVID-19

Torre-Fonseca¹,

Loor-Cedeño²,

Alarcón-Cedeño³

et al. 2022

RCCAR

View full text Add to dashboard Cite

Introducción: Como consecuencia del daño directo provocado por el virus SARS-CoV-2 sobre el corazón se producen alteraciones electrocardiográficas. Objetivo: Determinar si existe relación entre las alteraciones electrocardiográficas intrahospitalarias, con los antecedentes cardiovasculares y su evolución hospitalaria. Materiales y método: Estudio de cohortes, prospectivo, analítico, en 373 pacientes con el diagnóstico positivo de enfermedad por el nuevo coronavirus 2019 que ingre-

show abstract

Cardiac Arrhythmias in Patients with COVID-19: A Systematic review and Meta-analysis

Cited by 6 publications

References 29 publications

Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews

Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews

Cardiac Manifestations in Patients with COVID-19: A Scoping Review

Alteraciones electrocardiográficas en pacientes hospitalizados con COVID-19

Contact Info

Product

Resources

About