Cardiac benefits of exercise training in aging spontaneously hypertensive rats

Rossoni, Luciana Venturini; Oliveira, Raphael Augusto Fernandes de; Caffaro, R.R.; Miana, María; Sanz-Rosa, David; Koike, Márcia Kiyomi; Amaral, Sandra Lia do; Michelini, Lisete Compagno; Lahera, Vicente; Cachofeiro, Victoria

doi:10.1097/hjh.0b013e32834d2532

Cited by 48 publications

(49 citation statements)

References 49 publications

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“…Improved functional capacity in SHR occurred despite a slight increase in arterial blood pressure compared to SHR-SED. The effects of exercise on SHR blood pressure are variable; some authors have shown an anti-hypertensive effect of exercise [19], others found hypertension unchanged [52,53] or even exacerbated [54]. The low intensity exercise protocol did not change body weight.…”

Section: Discussionmentioning

confidence: 98%

“…We therefore conclude that long-term physical exercise attenuated increase in myocardial collagen content and lysyl oxidase gene expression. It has previously been shown that exercise training in both normotensive and hypertensive aging rats attenuates myocardial fibrosis and modulates myocardial collagen gene expression [19,59]. …”

Section: Discussionmentioning

confidence: 99%

“…Exercise testing was performed on a graded treadmill. The speed started at 6 m/min and was increased by 3 m/min every 3 min until rats were unable to run [19]. Rats were considered to be exhausted when they refused to run even after sound stimulation or were unable to coordinate steps.…”

Section: Methodsmentioning

confidence: 99%

“…In stable chronic heart failure, clinical studies have shown that long-term moderate physical training attenuates abnormal cardiac remodeling and improves functional capacity and quality of life [10,11,12,13]. In different cardiac injury models, exercise has been shown to attenuate left ventricular dilation, myocyte hypertrophy, myocardial fibrosis, mitochondrial dysfunction, myocyte calcium handling changes, sympathoexcitation, cardiac dysfunction, and improve inflammatory profile [14,15,16,17,18,19,20,21,22]. …”

Section: Introductionmentioning

confidence: 99%

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Long-Term Low Intensity Physical Exercise Attenuates Heart Failure Development in Aging Spontaneously Hypertensive Rats

Pagan

Damatto

Cezar

et al. 2015

Cell Physiol Biochem

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Background: Physical exercise is a strategy to control hypertension and attenuate pressure overload-induced cardiac remodeling. The influence of exercise on cardiac remodeling during uncontrolled hypertension is not established. We evaluated the effects of a long-term low intensity aerobic exercise protocol on heart failure (HF) development and cardiac remodeling in aging spontaneously hypertensive rats (SHR). Methods: Sixteen month old SHR (n=50) and normotensive Wistar-Kyoto (WKY, n=35) rats were divided into sedentary (SED) and exercised (EX) groups. Rats exercised in treadmill at 12 m/min, 30 min/day, 5 days/week, for four months. The frequency of HF features was evaluated at euthanasia. Statistical analyses: ANOVA and Tukey or Mann-Whitney, and Goodman test. Results: Despite slightly higher systolic blood pressure, SHR-EX had better functional capacity and lower HF frequency than SHR-SED. Echocardiography and tissue Doppler imaging showed no differences between SHR groups. In SHR-EX, however, left ventricular (LV) systolic diameter, larger in SHR-SED than WKY-SED, and endocardial fractional shortening, lower in SHR-SED than WKY-SED, had values between those in WKY-EX and SHR-SED not differing from either group. Myocardial function, assessed in LV papillary muscles, showed improvement in SHR-EX over SHR-SED and WKY-EX. LV myocardial collagen fraction and type I and III collagen gene expression were increased in SHR groups. Myocardial hydroxyproline concentration was lower in SHR-EX than SHR-SED. Lysyl oxidase gene expression was higher in SHR-SED than WKY-SED. Conclusion: Exercise improves functional capacity and reduces decompensated HF in aging SHR independent of elevated arterial pressure. Improvement in functional status is combined with attenuation of LV and myocardial dysfunction and fibrosis.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long-Term Low Intensity Physical Exercise Attenuates Heart Failure Development in Aging Spontaneously Hypertensive Rats

Pagan

Damatto

Cezar

et al. 2015

Cell Physiol Biochem

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“…us one of the major bene�ts of exercise training in hypertension is the preservation of cardiomyocyte cell number. Despite the potential for exercise training to increase myocardial mass in pressure overload, most studies have reported an improved phenotype aer training [25,30,46,61,[80][81][82][83][84][85][86][87]. One of the most proli�c bene�ts of exercise training is its improvement on adrenergic signaling.…”

Section: Cardiac Remodelingmentioning

confidence: 99%

Cardiac Effects of Exercise Training in Hypertension

Libonati

2013

ISRN Hypertension

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Hypertension is a signi�cant health concern. Hypertension leads to compensatory pathologic hypertrophy and impaired cardiac function. Lifestyle modi�cations such as exercise are encouraged for hypertensive patients. Some studies have shown that exercise training can reverse pathological hypertrophy. Conversely, studies on animal models of hypertension have shown increased cardiac growth with exercise training. Despite the further induction of hypertrophy, exercise training seems protective against cell death and may increase cardiomyocyte proliferation, leading to a putative phenotype. �ne of the hallmark bene�cial effects of exercise in hypertension is an improvement in myocardial adrenergic responsiveness. e focus of this paper is to discuss how exercise training impacts cardiac remodeling and function in the hypertensive heart with speci�c reference to adrenergic signaling.

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Differential effects of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats

Tardelli

Duchatsch

Herrera

et al. 2021

J of Applied Toxicology

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Dexamethasone (DEX)‐induced hypertension is observed in normotensive rats, but little is known about the effects of DEX on spontaneously hypertensive animals (SHR). This study aimed to evaluate the effects of DEX on hemodynamics, cardiac hypertrophy and arterial stiffness in normotensive and hypertensive rats. Wistar rats and SHR were treated with DEX (50 μg/kg s.c., 14 d) or saline. Pulse wave velocity (PWV), echocardiographic parameters, blood pressure (BP), autonomic modulation and histological analyses of heart and thoracic aorta were performed. SHR had higher BP compared with Wistar, associated with autonomic unbalance to the heart. Echocardiographic changes in SHR (vs. Wistar) were suggestive of cardiac remodeling: higher relative wall thickness (RWT, +28%) and left ventricle mass index (LVMI, +26%) and lower left ventricle systolic diameter (LVSD, −19%) and LV diastolic diameter (LVDD, −10%), with slightly systolic dysfunction and preserved diastolic dysfunction. Also, SHR had lower myocardial capillary density and similar collagen deposition area. PWV was higher in SHR due to higher aortic collagen deposition. DEX‐treated Wistar rats presented higher BP (~23%) and autonomic unbalance. DEX did not change cardiac structure in Wistar, but PWV (+21%) and aortic collagen deposition area (+21%) were higher compared with control. On the other side, DEX did not change BP or autonomic balance to the heart in SHR, but reduced RWT and LV collagen deposition area (−12% vs. SHRCT). In conclusion, the results suggest a differential effect of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats.

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Cardiac benefits of exercise training in aging spontaneously hypertensive rats

Cited by 48 publications

References 49 publications

Long-Term Low Intensity Physical Exercise Attenuates Heart Failure Development in Aging Spontaneously Hypertensive Rats

Long-Term Low Intensity Physical Exercise Attenuates Heart Failure Development in Aging Spontaneously Hypertensive Rats

Cardiac Effects of Exercise Training in Hypertension

Differential effects of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats

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